Absorption and Presystemic Metabolism of Nefazodone Administered at Different Regions in the Gastrointestinal Tract of Humans

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 12, Issue 11, 1995, Pages 1716-1721

  Marathe, Punit H ^a   Salazar, Daniel E ^a   Greene, Douglas S ^a   Brennan, John ^b   Shukla, Umesh A ^c   Barbhaiya, Rashmi H ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Solvay Pharmaceuticals Inc   (Netherlands)

^c SANOFI   (France)

Author keywords

intubation; nefazodone; P450 metabolism; pharmacokinetics; site of absorption

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; CYTOCHROME P450; DRUG METABOLITE; HYDROXYNEFAZODONE; NEFAZODONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG HALF LIFE; DRUG METABOLISM; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DIGESTIVE SYSTEM; HUMANS; INTESTINAL ABSORPTION; INTUBATION, GASTROINTESTINAL; MALE; PIPERAZINES; SEROTONIN AGONISTS; SPECTROPHOTOMETRY, ULTRAVIOLET; TRIAZOLES;

EID: 0029559664     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1016265705932     Document Type: Article

References (15)

1. A comparison of nefazodone, imipramine, and placebo in patients with moderate to severe depression
2. Nefazodone: preclinical pharmacology of a new antidepressant
3. Characterization of the metabolites of antidepressant drug nefazodone in human urine and plasma
4. Pharmacokinetics of Nefazodone Following Multiple Escalating Oral Doses in the Dog
5. Nonlinear pharmacokinetics of nefazodone after escalating single and multiple doses
6. Identification of rifampin-inducible p450IIIa4 (cyp3a4) in human small bowel enterocytes
7. Metabolism of drugs and other xenobiotics in the gut lumen and wall
8. Pharmacokinetics of nefazodone in extensive (EM) and poor (PM) metabolizers of dextromethorphan
9. High-performance liquid chromatographic method for the determination of nefazodone and its metabolites in human plasma using laboratory robotics
10. Influence of gastrointestinal site of drug delivery on the absorption characteristics of ranitidine
11. Rectal drug administration: partial avoidance of hepatic first pass elimination
12. Sumatriptan absorption from different regions of the human gastrointestinal tract