Bcl-2 family proteins: regulators of chemoresistance in cancer

Toxicology Letters

Volumn 82-83, Issue C, 1995, Pages 155-158

  Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Apoptosis; Bcl 2 protein; Cancer; p53

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN; PROTEIN BCL 2;

CANCER; CONFERENCE PAPER; DRUG RESISTANCE; GENE EXPRESSION; HUMAN; NONHUMAN; ONCOGENE BCL2; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENES, P53; HUMANS; NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0029558583     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(95)03551-6     Document Type: Article

References (21)

1. Bcl-2 and the regulation of programmed cell death
2. Bcl-2: prevention of apoptosis as a mechanism of drug resistance
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4. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
5. Reversal of chemoresistance of lymphoma cells by antisense mediated reduction of bcl-2 gene expression
6. Androgens induce resistance to bcl-2-mediated apoptosis in LNCaP prostate cancer cells
7. Reduced expression of pro-apoptotic gene Bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
8. L by cytoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation
9. Tumor suppressor p53 is a regulator of bcl-2 and bax in gene expression in vitro and in vivo
10. Identification of a p53-dependent negative response element in the bcl-2 gene
11. Tumor suppressor p53 is a direct transcriptional activator of human bax gene
12. p53-dependent and independent expression of p21during cell growth, differentiation, and DNA damage
13. Induction of bax by genotoxic stress in human cells correlates with normal p53status and apoptosis
14. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
15. Interactions among members of the bcl-2 protein family analyzed with a yeast two-hybrid system
16. BH1 and BH2 domains of bcl-2 are required for inhibition of apoptosis and heterodimerization with bax
17. Structure-function analysis of bcl-2 protein: identification of conserved domains important for homodimerization with bcl-2 and heterodimerization with bax
18. Cloning and functional analysis of BAG-1: a novel Bcl-2 binding protein with anti-cell death activity
19. Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase