Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells

Vaccine

Volumn 13, Issue 18, 1995, Pages 1741-1749

  Moore, Anne ^a   McGuirk, Peter ^a   Adams, Susan ^a   Jones, Wendy C ^b   Paul McGee, J ^c   O'Hagan, Derek T ^c   Mills, Kingston H G ^a  

^a ST PATRICK S COLLEGE   (Ireland)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Biodegradable microparticle; cytotoxic T lymphocyte; HIV; recombinant vaccine; Th1 cell; vaccine delivery

Indexed keywords

BIODEGRADABLE MICROPARTICLE; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; RECOMBINANT PROTEIN; RECOMBINANT VACCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODY SPECIFICITY; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CYTOTOXICITY, IMMUNOLOGIC; DRUG CARRIERS; HIV ENVELOPE PROTEIN GP120; IMMUNIZATION; LACTIC ACID; MICE; MICE, INBRED BALB C; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; SOLUBILITY; TH1 CELLS;

EID: 0029558085     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0264-410X(95)00184-3     Document Type: Article

References (46)

1. Towards a vaccine for AIDS: the emergence of immunobiology-based vaccine development
2. Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160
3. Prevention of HIV infection by passive immunisation with HIV immunoglobulin
4. T cells and protective immunity to human and simian immunodeficiency viruses
5. Peptide-induced antiviral protection by cytotoxic T cells
6. Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein
7. Protection against vaginal SIV transmission with microencapsulated vaccine
8. Heterogeneity of cytokine secretion patterns and functions of helper T cells
9. + T cells
10. T helper cell immune dysfunction in asymptomatic HIV-1 seropositive individuals: the role of Th1/Th2 cross regulation
11. Cell mediated immune response to human immunodeficiency virus type 1 (HIV-1) in seronegative homosexuals with recent sexual exposure to HIV-1
12. H2 predominance in HIV-infected individuals
13. Cytokine patterns during the progression to AIDS
14. An alternative view of the Th1/Th2 switch hypothesis in HIV infection
15. An immunodominant epitope of the HIV envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes
16. T cell strategies in AIDS vaccine: MHC restricted T-cell responses to HIV proteins
17. Induction of cytotoxic T lymphocytes in vivo with protein antigen entrapped in membranous vehicles
18. In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine
19. + cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs
20. Induction of antigen-specific class I-restricted cytotoxic T cells by soluble proteins in vivo
21. Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide
22. Saponin adjuvant enhancement of antigen-specific immune responses to an experimental HIV-1 vaccine
23. The control of the antibody isotype response to recombinant human immunodeficiency virus gp120 antigen by adjuvants
24. Studies on the immunogenicity of CHO cell-derived recombinant gp120 (HIV1-IIIb)
25. Microparticles as potentially orally active immunological adjuvants
26. Biodegradable microspheres as a vaccine delivery system
27. Biodegradable microparticles for oral immunization
28. HIV p24-specific helper T cell clones from immunized primates recognize highly conserved regions of HIV-1
29. Preparative separation of foreign antigens for highly efficient presentation to T cells in vitro
30. Extensive diversity in the recognition of influenza virus haemagglutinin by murine T helper clones
31. Effective immunization against Bordetella pertussis is dependent on induction of cell-mediated immunity
32. Immunisation of chimpanzees confers protection against challenge with human immunodeficiency virus
33. Towards a vaccine against AIDS: lessons from simian immunodeficiency virus vaccines
34. Vaccine protection of chimpanzees against challenge with HIV-1-infected peripheral blood mononuclear cells
35. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
36. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
37. Induction of mucosal and systemic responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles
38. Different T helper subsets elicited in mice utilizing two different adjuvant vehicles: the role of endogenous interlukin I in proliferative responses
39. Distinct regulation of lymphokine production is found in fresh versus in vitro primed helper T cells
40. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen presenting cell populations
41. + Th1 clones with both cytotoxic activity and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor
42. Secretory antibody response to viral vaccines
43. The role of nasopharyngeal lymphoid tissue
44. Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals
45. Induction of HIV-specific T lymphocytes in vivo with hybrid HIV-1 V3:Ty-virus-like particles