The Effects and Pharmacokinetics of rhG‐CSF in Patients with Chronic Renal Failure

Artificial Organs

Volumn 19, Issue 12, 1995, Pages 1251-1257

  Akizawa, Tadao ^a   Shishido, Kanji ^a   Koshikawa, Shozo ^a  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Chronic renal failure; Neutrophil function; Pharmacokinetics; Recombinant human granulocyte colony stimulating factor

Indexed keywords

BLOOD; PATIENT TREATMENT; PHOSPHATASES;

ALKALINE PHOSPHATASE; BLOOD CELLS; CELL COUNT; CHRONIC RENAL FAILURE; IMMUNOLOGICAL FUNCTIONS; NEUTROPHIL FUNCTIONS; PERIPHERAL BLOOD; RECOMBINANT HUMAN GRANULOCYTE COLONY STIMULATING FACTORS; RENAL FAILURE; SINGLE-DOSE;

PHARMACOKINETICS;

RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; AGED; ARTICLE; BONE PAIN; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; HEMODIALYSIS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEUTROPHIL; PHARMACOKINETICS; PRIORITY JOURNAL;

EID: 0029556535     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/j.1525-1594.1995.tb02295.x     Document Type: Article

References (27)

1. Early phase 2 clinical study of KRN8601 (rhG–CSF)
2. Effect of recombinant human granulocyte colony stimulating factor (rhG–CSF) in patients receiving chemotherapy–phase I study
3. Treatment of aplastic anemia with KRN8601 (rhG–CSF)
4. Effects of recombinant human granulocyte colony–stimulating factor on neutropenia in patients with congenital agranulocytosis
5. 125I–KRN8601 after a single intravenous administration to rats
6. Estimation of plasma G–CSF concentration in healthy volunteers and leukemic patients using highly sensitive EUSA
7. Quantitation of neutrophil phagocytosis, using fluorescent latex beads: Correlation of microscopy and flow cytometry
8. Flow–cytometric evaluation of neutrophil functions on microquantities of whole blood
9. Flow cytometric studies of oxidative product formation by neutrophils: A graded response to membrane stimulation
10. Infection and nitro–blue–tetrazolium reduction by neutrophils: A diagnostic aid
11. Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes
12. Cellular cooperation in lymphocyte activation
13. Transient expression of interleukin 2 receptors
14. Simultaneous detection of dual surface marker
15. Phase I study of KRN8601 (rhG–CSF) in normal healthy volunteers: Safety and pharmacokinetics in single intravenous infusion
16. Phase I study of KRN8601 (rhG–CSF) in normal healthy volunteers: Safety and pharmacokinetics in consecutive intravenous infusion
17. Influence of renal and hepatic failure on the pharmacokinetics of recombinant human granulocyte colony–stimulating factor (KRN8601) in the rat
18. Recombinant human granulocyte colony–stimulating factor: In vitro and in vivo effects on myelopoiesis
19. Hematological consequences of renal failure
20. G–CSF
21. In vivo activation of human neutrophil functions by administration of recombinant human granulocyte colony– stimulating factor in patients with malignant lymphoma
22. Recombinant human granulocyte colony–stimulating factor repairs the abnormalities of neutrophils in patients with myelodysplastic syndromes and chronic myelogenous leukemia
23. Human granulocyte colony–stimulating factor: Biologic activities and receptor characterization on hematopoietic cells and small cell lung cancer cell lines
24. Clinical study of rhG–CSF (KRN8601) in patients with myelodysplastic syndrome
25. Actions and mechanism of G–CSF
26. Effects of recombinant human G–CSF on immunological parameters in patients with head and neck cancer
27. A trend of granulopoiesis and lymphocyte subsets before and after administration of rG–CSF in periodic neutropenia