Cytokine Involvement in Central Nervous System Disease: Implications from Transgenic Mice

Annals of the New York Academy of Sciences

Volumn 771, Issue 1, 1995, Pages 301-312

  CAMPBELL, IAIN L ^a   CHIANG, CHI‐SHIUN ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 6;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ASTROCYTE; CENTRAL NERVOUS SYSTEM DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; TRANSGENIC MOUSE;

EID: 0029556413     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1995.tb44690.x     Document Type: Article

References (52)

1. The cytokine network
2. Cytokines: an expanding network of immune hormones
3. Immunoregulators in the nervous system
4. Neuroendocrine‐immune interactions
5. Tumor necrosis factor identified in multiple‐sclerosis brain
6. Lymphokines and immunoregulatory molecules in subacute sclerosing panencephalitis
7. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
8. HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease
9. Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms
10. Cytokine expression in the brain during the acquired immunodeficiency syndrome
11. Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices
12. Brain interleukin 1 and S‐100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
13. Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute‐phase response gene expression in scrapie
14. Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis
15. Local production of tumor necrosis factor α, interleukin 1, and interleukin 6 in meningococcal meningitis
16. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action
17. Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: normal and pathological
18. On the cellular source and function of interleukin 6 produced in the central nervous system in viral disease
19. Tumor necrosis factor‐α production by astrocytes
20. Interleukin 1 of the central nervous system is produced by ameboid microglia
21. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus
22. Macrophage‐ and astrocyte‐derived transforming growth factor β as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome
23. Cytokine circuits in brain implications for AIDS dementia complex
24. Neurologic disease induced in transgenic mice by the cerebral overexpression of interleukin 6
25. Cerebral overexpression of interleukin‐6 or interferon‐α induces distinct neuropathology in transgenic mice
26. Reactive gliosis as a consequence of interleukin‐6 expression in the brain. Studies in transgenic mice
27. Gliosis and neurodegeneration as a consequence of the cerebral expression of IL‐3 in transgenic mice
28. Biology of multifunctional cytokines: IL6 and related molecules (IL 1 and TNF)
29. Biology of disease ‐ interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response
30. Human immunodeficiency virus type 1 (HIV‐1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid
31. Production of B cell stimulatory factor‐2 and interferon γ in the central nervous system during viral meningitis and encephalitis
32. Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system
33. Detection of interleukin‐1 and interleukin‐6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production
34. Induction and regulation of interleukin‐6 gene expression in rat astrocytes
35. Glial fibrillary acidic protein (GFA) in normal neural cells and in pathological conditions
36. Regulation of glial fibrillary acidic protein (GFAP) expression in CNS development and in pathological states
37. Astroglia in CNS injury
38. Site‐specific hippocampal pathophysiology due to cerebral overexpression of interleukin‐6 in transgenic mice
39. Proliferation of astrocytes in vitro in response to cytokines
40. Molecular profile of reactive astrocytes—implications for their role in neurologic disease
41. Proliferative angiopathy in the brain induced by the cerebral overexpression of interleukin‐6 in transgenic mice
42. Cytokines in health and disease
43. Cytokine therapeutics: lessons from interferon α
44. The interferons: mechanisms of action and clinical applications
45. Central nervous system toxicity of interferons and other cytokines
46. Interleukin 3: from colony‐stimulating factor to pluripotent immunoregulatory cytokine
47. Colony‐stimulating factors as promoters of ameboid microglia
48. Lymphokine induction of rat microglia multinucleated giant cell formation
49. Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors
50. Patterns of cytokine gene expression by CD4+ T cells from young and old mice
51. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity