Inhibition of DNA Adduct Formation of 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) by Dietary Indole‐3‐carbinol (I3C) in the Mammary Gland, Colon, and Liver of the Female F‐344 Rat

Annals of the New York Academy of Sciences

Volumn 768, Issue 1, 1995, Pages 210-214

  SCHUT, HERMAN A J ^a   DASHWOOD, RODERICK H ^b  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 3 INDOLEMETHANOL; ANTINEOPLASTIC AGENT; DNA;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; BREAST CARCINOGENESIS; CANCER INHIBITION; CHEMOPROPHYLAXIS; COLON CARCINOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA ADDUCT; DRUG STRUCTURE; FEMALE; LIVER CARCINOGENESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALIA;

EID: 0029555748     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1995.tb12124.x     Document Type: Article

References (15)

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4. Activation of the food‐derived mutagen 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P450
5. Role of sulfation and acetylation in the activation of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) to intermediates which bind to DNA
6. Enzymatic phase II activation of the N‐hydroxylamines of IQ, MeIQx, and PhIP by various organs of monkeys and rats
7. Formation of DNA adducts of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) in male Fischer‐344 rats
8. 32P‐Postlabeling analysis of IQ, MeIQx, and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ‐, MeIQx‐, and PhIP‐treated monkeys
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11. Mechanisms of anticarcinogenesis by indole‐3‐carbinol: studies of enzyme induction, electrophile‐scavenging, and inhibition of aflatoxin activation
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13. Long‐term responses of women to indole‐3‐carbinol or a high fiber diet
14. Inhibition of polycyclic aromatic hydro‐carbon‐induced neoplasia by naturally occurring indoles
15. Effects of dietary indole‐3‐carbinol on estradiol metabolism and spontaneous mammary tumors in mice