Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

Immunity

Volumn 3, Issue 6, 1995, Pages 739-745

  Miller, Stephen D ^a   Vanderlugt, Carol L ^a   Lenschow, Deborah J ^b   Pope, Jonathan G ^a   Karandikar, Nitin J ^a   Dal Canto, Mauro C ^c   Bluestone, Jeffrey A ^b  

^a Department of Microbiology Immunology ^*  (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; EPITOPE; MONOCLONAL ANTIBODY; PROTEOLIPID PROTEIN; SYNTHETIC PEPTIDE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ETIOLOGY; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, BLOCKING; ANTIGENS, CD28; ANTIGENS, CD80; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES, T-LYMPHOCYTE; FEMALE; MICE; MYELIN PROTEINS; RATS; RECURRENCE; T-LYMPHOCYTES;

EID: 0029553431     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90063-2     Document Type: Article

References (31)

1. New perspectives of CD28-87-mediated T cell costimulation
2. Primary demyelination in Theiler's virus infection: an ultrastructural study
3. Treatment of murine lupus with CTLA41g
4. Genetic and molecular aspects of demyelination
5. Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 176–191) for SJL mice
6. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation
7. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
8. The B7 and CD28 receptor families
9. B7-1 and B7-2 costimulatory molecules differentially activate the Th1/Th2 developmental pathways: application to autoimmune disease therapy
10. Determinant spreading and the dynamics of the autoimmune T-cell repertoire
11. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA41g
12. Expression and functional significance of an additional ligand for CTLA-4
13. Differential up-regulation of the B7-1 and 87-2 costimulatory molecules after Ig receptor engagement by antigen
14. Differential effects of antiB7-1 and anti-87-2 MAb treatment on the development of diabetes in the NOD mouse
15. Inhibition of transplant rejection following treatment with anti-B7-2 and anti-87-1 antibody
16. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA41g plus donor-specific transfusion
17. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
18. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
19. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule
20. Induction of active and adoptive chronic-relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein
21. Functional evidence for epitope spreading in the relapsing pathology of EAE in the SJL/J mouse
22. The immunopathogenesis and regulation of T-cell mediated demyelinating diseases
23. Evolution of the T cell repertoire during the course of experimental autoimmune encephalomyelitis
24. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
25. Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression
26. Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis
27. Kinetics and specificity of T and B cell responses in relapsing experimental allergic encephalomyelitis
28. Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance
29. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice
30. CTLA-4 can function ass negative regulator of T cell activation
31. Immunopathogenesis of multiple sclerosis