Signal Transduction Interception as a Novel Approach to Disease Management

Annals of the New York Academy of Sciences

Volumn 766, Issue 1, 1995, Pages 363-368

  LEVITZKI, ALEXANDER ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b SUGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; AG 213; AG 538; ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIPSORIASIS AGENT; ENZYME INHIBITOR; ERBSTATIN; GENISTEIN; LAVENDUSTIN A; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG MECHANISM; DRUG STRUCTURE; SIGNAL TRANSDUCTION;

EID: 0029553207     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1995.tb26686.x     Document Type: Article

References (22)

1. Signal transduction therapy‐A novel approach to disease management
2. Tyrosine kinase inhibition: An approach to drug development of many drugs
3. A dominant negative mutation suppresses the function of normal EGF receptors by heterodimerization
4. Inhibition of glioma cell growth by a truncated platelet‐derived growth factor‐ß receptor
5. Dominant‐negative mutants of platelet‐derived growth factor revert the transformed phenotype of human astrocytoma cells
6. Blocking of EGF‐dependent cell proliferation by EGF receptor kinase inhibitors
7. The antiproliferative effects of tyrosine kinase inhibitor tyrphostin on a human squamous cell carcinoma in witro and in nude mice
8. 4,5‐Dianilinophathalmide: A protein tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity
9. bcr‐abl tyrosine kinase activity induces K562 to differentiate
10. Selective PDGF receptor kinase blockers reverse sis‐transformation
11. The effect of tyrosine specific protein phosphorylation on the assembly of adherents‐type junctions
12. Effects of tyrophostins on the activated c‐src protein in NIH/3T3 cells
13. The pathogenesis of atherosclerosis: A perspective for the 1990s
14. Tyrphostins inhibit PDGF‐induced DNA synthesis and associated early events in smooth muscle cells
15. Prevention of lipopolysaccharide‐induced lethal toxicity by tyrosine kinase inhibitors
16. Tyrphostins suppress the growth of psoriatic keratinocytes
17. High affinity VEGF binding and developmental expression suggest Flk‐1 as a major regulator of vasculogenesis and angiogenesis
18. Glioblastoma growth inhibited in vivo by a dominant‐negative Flk‐1 mutant
19. Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction
20. Kinetics of inhibition of the tyrosine kinase activity of the epidermal growth factor receptor by tyrphostins
21. Selective interactions of transforming and normal abl proteins with ATP, tyrosine copolymer substrates and tyrphostins