Menopause: Its epidemiology and potential association with chronic diseases

Epidemiologic Reviews

Volumn 17, Issue 2, 1995, Pages 287-302

  Sowers, Maryfran R ^a   La Pietra, Margaret T ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DENSITY; CALCIUM MOBILIZATION; CARDIOVASCULAR DISEASE; CHRONIC DISEASE; DEPRESSION; FRACTURE; HOT FLUSH; HYPERTENSION; MENOPAUSE; MORBIDITY; OBESITY; OSTEOARTHRITIS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; URINARY TRACT INFECTION; URINE INCONTINENCE;

AGE FACTORS; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; CLIMACTERIC; FEMALE; GONADAL STEROID HORMONES; HUMANS; MENOPAUSE; OBESITY; OSTEOPOROSIS, POSTMENOPAUSAL; UNITED STATES;

EID: 0029551426     PISSN: 0193936X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.epirev.a036194     Document Type: Article

References (208)

1. Alexander RD. How did humans evolve? Reflections on the uniquely unique species. Ann Arbor, MI: Museum of Zoology, The University of Michigan, 1990:12-16. (Special publication no. 1)
2. Lancaster J, King B. An evolutionary perspective on menopause. In: Brown JK, Kerns V, eds. In her prime: new views on middle-aged women. South Hadley, MA: Bergin and Garvey Publishers, 1985:13-20.
3. Gaulin SJ. Sexual dimorphism in human post-reproductive lifespan: possible causes. J Hum Evol 1980;9:227-232.
4. Turke PW. Evolution and the demand for children. Popul Dev Rev 1989;15:61-90.
5. Khaw KT. Epidemiology of the menopause. Br Med Bull 1992, 48:249-261.
6. Snowdon DA, Kane RL, Beeson WL, et al. Is early natural menopause a biologic marker of health and aging? Am J Public Health 1989;79:709-714.
7. Research on the menopause. Geneva, Switzerland: World Health Organization, 1981. (World Health Organization technical report series 670)
8. Upton GV. The perimenopause: physiologic correlates and clinical management. J Reprod Med 1982;27:l-27, editorial comment 27-8
9. Treloar AE, Boynton RE, Behn BG, et al. Variation of the human menstrual cycle through reproductive life. Int J Fertil 1970;12:77-126.
10. McKinlay SM, Brambilla DJ, Posner JG. The normal menopause transition. Maturitas 1992; 14:103-115.
11. Metcalf MG, Donald RA, Livesey JH. Pituitary-ovarian function before, during, and after the menopause: a longitudinal study. Clin Endocrinol 1982;17:489-494.
12. van Look PF, Lothian H, Hunter WM, et al. Hypothalamicpituitary- ovarian function in perimenopausal women. Clin Endocrinol 1977;7:13-31.
13. Vagenakis AG. Endocrine aspects of menopause. Clin Rheumatol 1989;8(2):48-51.
14. Sherman BM, West JH, Korenman SG. The menopausal transition: analysis of LH, FSH, estradiol, and progesterone concentrations during menstrual cycles of older women. J Clin Endocrinol Metab 1976;42:629-636.
15. Reyes FI, Winter JSD, Faiman C. Pituitary-ovarian relationships preceding the menopause. I. A cross-sectional study of serum follicle-stimulating hormone, leuteinizing hormone, prolactin, estradiol, and progesterone levels. Am J Obstet Gynecol 1977;129:557-564.
16. Vollman RF. The menstrual cycle. Vol 7. Major problems in obstetrics and gynecology. Philadelphia, PA: WB Saunders Company, 1977.
17. Metcalf MG. Incidence of ovulatory cycles in women approaching the menopause. J Biosoc Sci 1979;11:39-48.
18. Rutherford AM. The menopause. N Z Med J 1978;87:251-3.
19. Ballinger CB, Browning MCK, Smith AHW. Hormone profiles and psychological symptoms in peri-menopausal women. Maturitas 1987;9:235-51.
20. Chakravarti S, Collins WP, Forecast JD, et al. Hormonal profiles after the menopause. Br Med J 1976;2:784-7.
21. Scaglia H, Medina M, Pinto-Ferreira AL, et al. Pituitary LH and FSH secretion and responsiveness in women of old age. Acta Endocrinol (Copenh) 1976;81:673-679.
22. Baird DT, Guevara A. Concentration of unconjugated estrone and estradiol in peripheral plasma in nonpregnant women throughout the menstrual cycle, castrate and postmenopausal women, and in men. J Clin Endocrinol Metab 1969;29:149-156.
23. Longcope C. Metabolic clearance and blood production rates of estrogens in postmenopausal women. Am J Obstet Gynecol 1971;111:778-781.
24. Longcope C, Franz C, Morello C, et al. Steroid and gonadotropin levels in women during the peri-menopausal years. Maturitas 1986;8:189-196.
25. Rannevik G, Carlstrom K, Jeppsson S, et al. A prospective long-term study of women from pre-menopause to postmenopause: changing profiles of gonadotropins, oestrogens, and androgens. Maturitas 1986, 8:297-307.
26. Trevoux R, De Brux J, Castanier M, et al. Endometrium and plasma hormone profile in the peri-menopause and postmenopause. Maturitas 1986;8:309-326.
27. Lucisano A, Russo N, Acampora MG, et al. Ovarian and peripheral androgen and oestrogen levels in post-menopausal women: correlations with ovarian histology. Maturitas 1986; 8:57-65.
28. De Waard F, Pot H, Tonckens-Nanninga NE, et al. Longitudinal studies on the phenomenon of postmenopausal estrogen production. Acta Cytol 1972;16:273-278.
29. Grattarola R, Secreto G, Recchione C. Correlation between urinary testosterone or estrogen excretion levels and interstitial cell-stimulating hormone concentrations in normal postmenopausal women. Am J Obstet Gynecol 1975, 121:380-381.
30. Mattingly RF, Huang WY. Steroidogenesis in the menopausal and postmenopausal ovary. Am J Obstet Gynecol 1969;103:679-93.
31. Cauley JA, Gutai JP, Kuller LH, et al. Reliability and interrelations among serum sex hormones in postmenopausal women. Am J Epidemiol 1991;133:50-7.
32. Treloar AE. Menarche, menopause, and intervening fecundability. Hum Biol 1974;46:89-107.
33. MacMahon B, Worcester J. Age at menopause, United States 1960-1962. Rockville, MD: US Department of Health, Education, and Welfare, Public Health Service, National Center for Health Statistics, 1966:1-19. (Vital and health statistics, series 1, vol 11, no. 19).
34. Scragg RFR. Menopause and reproductive span in rural Niugini. In: Proceedings of the annual symposium of the Papua New Guinea Medical Society. Port Moresby, Papua New Guinea: Papua New Guinea Medical Society, 1973: 126-44.
35. Willett W, Stampfer MJ, Bain C, et al. Cigarette smoking, relative weight, and menopause. Am J Epidemiol 1983:117: 651-658.
36. Brand PC, Lehert PH. A new way of looking at environmental variables that may affect the age at menopause. Maturitas 1978;1:121-132.
37. Adena MA, Gallagher HG. Cigarette smoking and the age at menopause. Ann Hum Biol 1982;9:121-30.
38. Baron JA. Smoking and estrogen-related disease. Am J Epidemiol 1984;119:9-22.
39. Lindquist O, Bengtsson C. The effect of smoking on menopausal age. Maturitas 1979;1:171-3.
40. Jick H, Porter J. Relation between smoking and age of natural menopause. Report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center. Lancet 1977;2:1354-5.
41. Andersen FS, Transbol I, Christiansen C. Is cigarette smoking a promotor of the menopause? Acta Med Scand 1982; 212:137-9.
42. McKinlay SM, Bifano NL, McKinlay JB. Smoking and age at menopause in women. Ann Intern Med 1985;103:350-6.
43. Brambilla DJ, McKinlay SM. A prospective study of factors affecting age at menopause. J Clin Epidemiol 1989;42: 1031-9.
44. Mattison DR, Thorgeirsson SS. Smoking and industrial pollution, and their effects on menopause and ovarian cancer. Lancet 1978;1:187-188.
45. Michnovicz JJ, Hershcopf RJ, Naganuma H, et al. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med 1986;315:1305-1309.
46. Longcope C, Johnston CC. Androgen and estrogen dynamics in pre- and postmenopausal women: a comparison between smokers and nonsmokers. J Clin Endocrinol Metab 1988;67:379-83.
47. Whelan EA, Sandier DP, McConnaughey DR, et al. Menstrual and reproductive characteristics and age at natural menopause. Am J Epidemiol 1990;131:625-32.
48. Stanford JL, Hartge P, Brinton LA, et al. Factors influencing the age at natural menopause. J Chronic Dis 1987;40: 995-1002.
49. van Keep PA, Brand PC, Lehert P. Factors affecting the age at menopause. J Biosoc Sci 1979;6(1):37-55.
50. Richardson SJ, Nelson JF. Follicular depletion during the menopausal transition. Ann N Y Acad Sci 1990;592:13-20.
51. Utian WH. The place of oestriol therapy after menopause. Acta Endocrinol Suppl (Copenh) 1980;233:51-6.
52. McKinlay SM, Jefferys M. The menopausal syndrome. Br J Prev Soc Med 1974;28:108-15.
53. Voda AM, Feldman BM, Gronseth E. Description of the hot flash: sensations, meaning, and change in frequency across time. In: Notelovitz N, van Keep PA, eds. The climacteric in perspective. Proceedings of the Fourth International Congress on the Menopause, Lake Buena Vista, Florida, October 28 to November 2, 1984. Boston, MA: MTP Press, 1984: 259-69.
54. Neugarten BL, Kraines RJ. "Menopausal symptoms" in women of various ages. Psychosom Med 1965;27:266-73.
55. Thompson B, Hart SA, Durno D. Menopausal age and symptomatology in a general practice. J Biosoc Sci 1973;5:71-82.
56. Kronenberg F, Downey JA. Thermoregulatory physiology of menopausal hot flashes: a review. Can J Physiol Pharmacol 1987;65:1312-24.
57. Kronenberg F. Hot flashes: epidemiology and physiology. Ann N Y Acad Sci 1990;592:52-86, discussion 123-33
58. Cignarelli M, Cicinelli E, Corso M, et al. Biophysical and endocrine-metabolic changes during menopausal hot flashes: increase in plasma free fatty acid and norepinephrine levels. Gynecol Obstet Invest 1989;27:34-7.
59. Albright DL, Voda AM, Smolensky MH, et al. Circadian rhythms in hot flashes in natural and surgically-induced menopause. Chronobiol Int 1989;6:279-84.
60. Lock M. Contested meanings of the menopause. Lancet 1991;337:1270-2.
61. Beyene Y. Cultural significance and physiological manifestations of menopause: a bicultural analysis. Cult Med Psychiatry 1986;10:47-71.
62. Thornton JG. Menopausal hot flushes: personal experience in Africa. (Letter). Trop Doct 1984;14:135.
63. Sherman BM, Wallace RB, Bean JA, et al. The relationship of menopausal hot flushes to medical and reproductive ex- perience. J Gerontol 1981;36:306-309.
64. Brincat M, Magos A, Studd JW, et al. Subcutaneous hormone implants for the control of climacteric symptoms: a prospective study. Lancet 1984;1:16-18.
65. Ballinger S. Stress as a factor in lowered estrogen levels in the early postmenopause. Ann N Y Acad Sci 1990;592: 95-113.
66. Henneman DH. Effect of estrogen on in vivo and in vitro collagen biosynthesis and maturation in old and young female guinea pigs. Endocrinology 1968;83:678-90.
67. Kao KY, Hitt WE, McGavack TH. Connective tissue XIII. Effect of estradiol benzoate upon collagen synthesis by sponge biopsy connective tissue. Proc Soc Exp Biol Med 1965;119:364-7.
68. Smith QT, Allison DJ. Changes of collagen content in skin, femur and uterus of 17-beta-estradiol benzoate-treated rats. Endocrinology 1966;79:486-92.
69. Uitto J. Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin 1986;4:433-446.
70. Rucker RB, Murray J. Cross-linking amino acids in collagen and elastin. Am J Clin Nutr 1978;31:1221-36.
71. Brincat M, Moniz CJ, Studd JWW, et al. Long-term effects of the menopause and sex hormones on skin thickness. Br J Obstet Gynecol 1985;92:256-259.
72. Brincat M, Kabalan S, Studd JW, et al. A study of the decrease of skin collagen content, skin thickness, and bone mass in the postmenopausal woman. Obstet Gynecol 1987; 70:840-845.
73. Brincat M, Yuen AW, Studd JW, et al. Response of skin thickness and metacarpal index to estradiol therapy in postmenopausal women. Obstet Gynecol 1987;70:538-41.
74. Hallstrom T. Sexuality in the climacteric. Clin Obstet Gynaecol 1977;4:227-39.
75. Davidson JM, Gray GD, Smith ER. The sexual psychoendocrinology of aging. In: Meites J, ed. Neuroendocrinology of aging. New York, NY: Plenum Press, 1983:221-58.
76. Myers JK, Lindenthal JJ, Peper MP. Life events, social integration, and psychiatric symptomatology. J Health Soc Behav 1975;16:421-427.
77. McKinlay JB, McKinlay SM, Brambilla D. The relative contributions of endocrine changes and social circumstances to depression in mid-aged women. J Health Soc Behav 1987;28:345-363.
78. Dennerstein L. Depression in the menopause. Obstet Gynecol Clin North Am 1987;14:33-48.
79. Hallstrom T, Samuelsson S. Mental health in the climacteric: the longitudinal study of women in Gothenburg. Acta Obstet Gynecol Scand Suppl 1985;130:13-18.
80. Gath D, Osborn M, Bungay G, et al. Psychiatric disorder and gynaecological symptoms in middle aged women: a community survey. Br Med J (Clin Res Ed) 1987;294:213-218.
81. Kaufert PA, Gilbert P, Hassard T. Researching the symptoms of menopause: an exercise in methodology. Maturitas 1988; 10:117-131.
82. Winokur G. Depression in the menopause. Am J Psychiatry 1973; 130:92-93.
83. Smith WG. Critical life-events and prevention strategies in mental health. Arch Gen Psychiatry 1971;25:103-109.
84. Coope J. Is oestrogen therapy effective in the treatment of menopausal depression? J R Coll Gen Pract 1981;31: 134-140.
85. Bungay GT, Vessey MP, McPherson CK. Study of symptoms in middle life with special reference to the menopause. BrMed J 1980;281:181-183.
86. Cooke DJ. A psychosocial study of the climacteric. In: Broome A, Wallace L, eds. Psychology and gynaecological problems. London, England: Tavistock Publications, 1984: 243-65.
87. Hunter M, Battersby R, Whitehead M. Relationships between psychological symptoms, somatic complaints, and menopausal status. Maturitas 1986;8:217-128.
88. Matthews KA, Wing RR, Kuller LH, et al. Influences of natural menopause on psychological characteristics and symptoms of middle-aged healthy women. J Consult Clin Psychol 1990;58:345-351.
89. Hunter MS. Psychological and somatic experience of the menopause: a prospective study. Psychosom Med 1990;52: 357-367.
90. Severne L. Coping with life events and stress at the climacteric. In: Notelovitz N, van Keep PA, eds. The climacteric in perspective. Proceedings of the Fourth International Congress on the Menopause, Lake Buena Vista, Florida, October 28 to November 2, 1984. Boston, MA: MTP Press, 1986: 212-32.
91. van Keep PA. The menopause. Part B. Psychosomatic aspects of the menopause. In: Dennerstein L, Burrows GD, eds. Handbook of psychosomatic obstetrics and gynaecology. New York, NY: Elsevier Biomedical Press, 1983:483-490.
92. Oldenhave A, Jaszmann LJ, Haspels AA, et al. Impact of climacteric on well-being: a survey based on 5, 213 women 39 to 60 years old. Am J Obstet Gynecol 1993; 168:772-780.
93. Miodrag A, Castleden CM, Vallance TR. Sex hormones and the female urinary tract. Drugs 1988;36:491-504.
94. Versi E. Incontinence in the climacteric. Clin Obstet Gynecol 1990;33:392-398.
95. Hording U, Pedersen KH, Sidenius K, et al. Urinary incontinence in 45-year-old women: an epidemiological survey. Scand J Urol Nephrol 1986;20:183-186.
96. Iosif S, Henriksson L, Ulmsten U. The frequency of disorders of the lower urinary tract, urinary incontinence in particular, as evaluated by a questionnaire survey in a gynaecological health control population. Acta Obstet Gynecol Scand 1981, 60:71-76.
97. Feneley RCL, Shepherd AM, Powell PH, et al. Urinary incontinence: prevalence and needs. Br J Urol 1979;51: 493-496.
98. Thomas TM, Plymat KR, Blannin J, et al. Prevalence of urinary incontinence. Br Med J 1980;281:1243-1245.
99. Hagstad A, Janson PO. The epidemiology of climacteric symptoms. Acta Obstet Gynecol Scand Suppl 1986; 134: 59-65.
100. Milsom I, Ekelund P, Molander U, et al. The influence of age, parity, oral contraception, hysterectomy, and menopause on the prevalence of urinary incontinence in women. J Urol 1993;149:1459-1462.
101. Fantl A, Wyman JF, Anderson RL, et al. Postmenopausal urinary incontinence: comparison between non-estrogensupplemented and estrogen-supplemented women. Obstet Gynecol 1988;71:823-828.
102. Kunin CM, McCormack RC. An epidemiologic study of bacteriuria and blood pressure among nuns and working women. N Engl J Med 1968;278:635-642.
103. Evans DA, Willians DN, Laughlin LW, et al. Bacteriuria in a population-based cohort of women. J Infect Dis 1978;138: 768-773.
104. Bengtsson C, Bengtsson U, Lincoln K. Bacteriuria in a population sample of women: prevalence, characteristics, results of treatment, and prognosis. Acta Med Scand 1980; 208:417-423.
105. Vorland LH, Carlson K, Aalen O. An epidemiological survey of urinary tract infections among outpatients in northern Norway. Scand J Infect Dis 1985;17:277-283.
106. Larsen B, Goplerud CP, Petzold CR, et al. Effect of estrogen treatment on the genital tract flora of postmenopausal women. Obstet Gynecol 1982;60:20-24.
107. Parsons CL. Lower urinary tract infections in women. Urol Clin North Am 1987, 14:247-250.
108. Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med 1993, 329:753-756.
109. Matthews KA. Myths and realities of the menopause. Psychosom Med 1992;54:l-9.
110. Flint MP. Sociology and anthropology of the menopause. In: van Keep PA, Serr DM, Greenblatt RB, eds. Female and male climacteric: current opinion, 1978. Lancaster, England: MTP Press, 1979:1-8.
111. Flint M, Samil RS. Cultural and subcultural meanings of the menopause. Ann N Y Acad Sci 1990;592:134-148, discussion 185-92
112. Maoz B. The perception of menopause in five ethnic groups in Israel. (Doctoral thesis). Leiden, Netherlands: University of Leiden, 1976.
113. Nordin BEC, Polley KJ. Metabolic consequences of the menopause: a cross-sectional, longitudinal, and intervention study on 557 normal postmenopausal women. Calcif Tissue Int 1987;41(1):5l-59.
114. Donovan JC. The menopausal syndrome: a study of case histories. Am J Obstet Gynecol 1951;62:1281-1291.
115. Goodman M. Toward a biology of menopause. Signs 1980; 5:739-53.
116. Kaufert P, Lock M, McKinlay S, et al. Menopause research: the Korpilampi workshop. Soc Sci Med 1986;22:1285-9.
117. Bjorntorp P. The associations between obesity, adipose tissue distribution, and disease. Acta Med Scand Suppl 1988;723: 121-134.
118. Block JE, Smith R, Glueer CC, et al. Models of spinal trabecular bone loss as determined by quantitative computed tomography. J Bone Miner Res 1989;4:249-257.
119. Elders PJ, Netelenbos JC, Lips P, et al. Accelerated vertebral bone loss in relation to the menopause: a cross-sectional study on lumbar bone density in 286 women of 46 to 55 years of age. Bone Miner 1988;5:11-19.
120. Hui SL, Slemenda CW, Johnston CC, et al. Effects of age and menopause on vertebral bone density. Bone Miner 1987; 2:141-6.
121. Johnston CC, Hui SL, Witt RM, et al. Early menopausal changes in bone mass and sex steroids. J Clin Endocrinol Metab 1985;61:905-906.
122. Ohta H, Makita K, Suda Y, et al. Influence of oophorectomy on serum levels of sex steroids and bone metabolism and assessment of bone mineral density in lumbar trabecular bone by QCT-C value. J Bone Miner Res 1992;7:659-665.
123. Ohta H, Ikeda T, Masuzawa T, et al. Differences in axial bone mineral density, serum levels of sex steroids, and bone metabolism between postmenopausal and age- and body size-matched premenopausal subjects. Bone 1993;14: 111-116.
124. Elders PJ, Netelenbos JC, Lips P, et al. Perimenopausal bone mass and risk factors. Bone Miner 1989;7:289-99.
125. Ribot C, Tremollieres F, Pouilles JM, et al. Influence of the menopause and aging on spinal density in French women. Bone Miner 1988;5:89-97.
126. Nilas L, Christiansen C. Rates of bone loss in normal women: evidence of accelerated trabecular bone loss after the menopause. Eur J Clin Invest 1988;18:529-534.
127. Mazzuoli G, Minisola S, Valtorta C, et al. Changes in mineral content and biochemical bone markers at the menopause. Isr J Med Sci 1985;21:875-877.
128. Geusens P, Dequeker J, Verstraeten A, et al. Age-, sex-, and menopause-related changes of vertebral and peripheral bone: population study using dual and single photon absorptiometry and radiogrammetry. J Nucl Med 1986;27:1540-1549.
129. Slemenda C, Hui SL, Longcope C, et al. Sex steroids and bone mass: a study of changes about the time of menopause. J Clin Invest 1987;80:1261-1269.
130. Gnudi S, Mongiorgi R, Figus E, et al. Evaluation of the relative rates of bone mineral content loss in postmenopause due to both estrogen deficiency and ageing. Boll Soc Ital Biol Sper 1990;66:1153-1159.
131. Nilas L, Christiansen C. The pathophysiology of peri- and postmenopausal bone loss. Br J Obstet Gynecol 1989;96: 589-587.
132. Reid IR, Ames R, Evans MC, et al. Determinants of total body and regional bone mineral density on normal postmenopausal women—a key role for fat mass. J Clin Endocrinol Metab 1992;75:45-51.
133. Steinberg KK, Freni-Tirulaer LW, DePuey EG, et al. Sex steroids and bone density in premenopausal and perimenopausal women. J Clin Endocrinol Metab 1989;69:533-9.
134. Hedlund LR, Gallagher JC. The effect of age and menopause on bone mineral density of the proximal femur. J Bone Miner Res 1989;4:639-42.
135. Stevenson JC, Lees B, Devenport M, et al. Determinants of bone density in normal women: risk factors for osteoporosis? BMJ 1989;298:924-8.
136. Sowers MR, Clark MK, Hollis B, et al. Radial bone mineral density in pre- and perimenopausal women: a prospective study of rates and risk factors for loss. J Bone Miner Res 1992;7:647-57.
137. Nilas L, Christiansen C. Bone mass and its relationship to age and the menopause. J Clin Endocrinol Metab 1987;65: 697-702.
138. Recker RR, Lappe JM, Davies KM, et al. Changes in bone mass immediately before menopause. J Bone Miner Res 1992;7:857-862.
139. Bagur AC, Mautalen CA. Risk for developing osteoporosis in untreated premature menopause. Calcif Tissue Int 1992; 51:4-7.
140. Johnell O, Nilsson BE. Life-style and bone mineral mass in perimenopausal women. Calcif Tissue Int 1984;36:354-356.
141. Gardsell P, Johnell O, Nilsson BE. The impact of menopausal age on future fragility fracture risk. J Bone Miner Res 1991;6:429-433.
142. Kritz-Silverstein D, Barrett-Connor E. Early menopause, number of reproductive years, and bone mineral density in postmenopausal women. Am J Public Health 1993;83: 983-938.
143. Seeman E, Cooper ME, Hopper JL, et al. Effect of early menopause on bone mass in normal women and patients with osteoporosis. Am J Med 1988;85:213-216.
144. Lee SJ, Kanis JA. An association between osteoporosis and premenstrual symptoms and postmenopausal symptoms. Bone Miner 1994;24:127-134.
145. Kreiger N, Kelsey JL, Holford TR, et al. An epidemiologic study of hip fracture in postmenopausal women. Am J Epidemiol 1982;116:141-148.
146. Kiel DP, Felson DT, Anderson JJ, et al. Hip fracture and the use of estrogens in postmenopausal women: The Framingham Study. N Engl J Med 1987;317:1169-1174.
147. Cooper C, Barker DJ, Wickham C. Physical activity, muscle strength, and calcium intake in fracture of the proximal femur in Britain. BMJ 1988;297:1443-1446.
148. Karlsson MK, Johnell O, Nilsson BE, et al. Bone mineral mass in hip fracture patients. Bone 1993; 14:161-165.
149. Kreiger N, Gross A, Hunter G. Dietary factors and fracture in postmenopausal women: a case-control study. Int J Epidemiol 1992;21:953-958.
150. Cumming DC. Menarche, menses, and menopause: a brief review. Cleve Clin J Med 1990;57:169-175.
151. Paganini-Hill A, Chao A, Ross RK, et al. Exercise and other factors in the prevention of hip fracture: the Leisure World Study. Epidemiology 1991;2:16-25.
152. Falch JA, Gautvik KM. A longitudinal study of pre- and postmenopausal changes in calcium metabolism. Bone 1988; 9:15-19.
153. Kelly PJ, Pocock NA, Sambrook PN, et al. Age and menopause-related changes in indices of bone turnover. J Clin Endocrinol Metab 1989;69:1160-1165.
154. Pansini F, Bonaccorsi G, Calisesi M, et al. Evaluation of bone metabolic markers as indicators of osteopenia in climacteric women. Gynecol Obstet Invest 1992;33:231-235.
155. Ribot C, Tremollieres F, Pouilles JM, et al. Obesity and postmenopausal bone loss: the influence of obesity on vertebral density and bone turnover in postmenopausal women. Bone 1987;8:327-331.
156. Mole PA, Walkinshaw MH, Robins SP, et al. Can urinary pyridinium crosslinks and urinary oestrogens predict bone mass and rate of bone loss after the menopause? Eur J Clin Invest 1992;22:767-771.
157. Parrish HM, Carr CA, Hall DG, et al. Time interval from castration in premenopausal women to development of excessive coronary atherosclerosis. Am J Obstet Gynecol 1967; 99:155-162.
158. Kuller LH, Meilahn EN, Gutai J, et al. Lipoproteins, estrogens, and the menopause. In: Korenman SG, ed. The menopause: biological and clinical consequences of ovarian failure: evolution and management. Norwell, MA: Serono Symposia USA, 1990:179-197.
159. Wren BG. The effect of oestrogen on the female cardiovascular system. Med J Aust 1992;157:204-208.
160. Stampfer MJ, Colditz GA, Willett WC. Menopause and heart disease: a review. Ann N Y Acad Sci 1990;592:193-203, discussion 257-62
161. Ettinger WH, Wahl PW, Kuller LH, et al. Lipoprotein lipids in older people: results from the Cardiovascular Health Study. The CHS Collaborative Research Group. Circulation 1992;86:858-69.
162. Matthews KA, Meilahn E, Kuller LH, et al. Menopause and risk factors for coronary heart disease. N Engl J Med 1989; 321:641-646.
163. Matthews KA, Wing RR, Kuller LH, et al. Influence of the perimenopause on cardiovascular risk factors and symptoms of middle-aged healthy women. Arch Intern Med 1994;154: 2349-2355.
164. Egeland GM, Kuller LH, Matthews KA, et al. Hormone replacement therapy and lipoprotein changes during early menopause. Obstet Gynecol 1990;76:776-782.
165. Meilahn EN. Hemostatic factors and risk of cardiovascular disease in women: an overview. Arch Pathol Lab Med 1992; 116:1313-117.
166. Meilahn EN, Kuller LH, Matthews KA, et al. Hemostatic factors according to menopausal status and use of hormone replacement therapy. Ann Epidemiol 1992; 2:445-455.
167. Meade TW, Dyer S, Howarth DJ, et al. Antithrombin III and procoagulant activity: sex differences and effects of the menopause. Br J Haematol 1990;74:77-81.
168. Lee AJ, Lowe GD, Smith WC, et al. Plasma fibrinogen in women: relationships with oral contraception, the menopause, and hormone replacement therapy. Br J Haematol 1993;83:616-621.
169. Scarabin PY, Bonithon-Kopp C, Bara L, et al. Factor VII activation and menopausal status. Thromb Res 1990;57: 227-234.
170. Coope J, Thomson JM, Poller L. Effects of "natural oestrogen" replacement therapy on menopausal symptoms and blood clotting. Br Med J 1975;4:139-143.
171. Berge LN, Lyngmo V, Svensson B, et al. The bleeding time in women: an influence of the sex hormones? Acta Obstet Gynecol Scand 1993;72:423-427.
172. Von Eiff AW, Plotz EJ, Beck KJ, et al. The effect of estrogens and progestins on blood pressure regulation of normotensive women. Am J Obstet Gynecol 1971;109: 887-892.
173. Weiss NS. Relationship of menopause to serum cholesterol and arterial blood pressure: the United States Health Examination Survey of adults. Am J Epidemiol 1972;96:237-241.
174. Eferakeya AE, Imasuen EJ. Role of socioeconomic factors on menopausal hypertension. Public Health 1986; 100: 100-104.
175. Staessen J, Bulpitt CJ, Fagard R, et al. The influence of menopause on blood pressure. J Hum Hypertens 1989;3: 427-433.
176. Hjortland MC, McNamara PM, Kannel WB. Some atherogenic concomitants of menopause: The Framingham Study. Am J Epidemiol 1976;103:304-306.
177. Shibata H, Matsuzaki T, Hatano S. Relationship of relevant factors of atherosclerosis to menopause in Japanese women. Am J Epidemiol 1979; 109:420-424.
178. Wu ZY, Wu XK, Zhang YM. Relationship of menopausal status and sex hormones to serum lipids and blood pressure. Int J Epidemiol 1990; 19:297-302.
179. Markovitz JH, Matthews KA, Wing RR, et al. Psychological, biological, and health behavior predictors of blood pressure changes in middle-aged women. J Hypertens 1991;9: 399-406.
180. Lindquist O, Bengtsson C, Lapidus L. Relationships between the menopause and risk factors for ischaemic heart disease. Acta Obstet Gynecol Scand Suppl 1985;130:43-47.
181. van Beresteyn ECH, van 't Hof MA, de Waard H. Contributions of ovarian failure and aging to blood pressure in normotensive perimenopausal women: a mixed longitudinal study. Am J Epidemiol 1989, 129:947-955.
182. van Beresteyn EC, Riedstra M, van der Wei A, et al. Habitual dietary calcium intake and blood pressure change around the menopause: a longitudinal study. Int J Epidemiol 1992;21: 683-689.
183. Lindquist O, Bengtsson C. Serum lipids, arterial blood pressure, and body weight in relation to the menopause: results from a population study in Goteborg, Sweden. Scand J Clin Lab Invest 1980;40:629-636.
184. Kannel WB, Hjortland MC, McNamara PM, et al. Menopause and risk of cardiovascular disease: The Framingham Study. Ann Intern Med 1976, 85:447-452.
185. Goemaere S, Ackerman C, Goethals K, et al. Onset of symptoms of rheumatoid arthritis in relation to age, sex, and menopausal transition. J Rheumatol 1990;17:1620-1622.
186. Persellin RH. The effect of pregnancy on rheumatoid arthritis. Bull Rheum Dis 1976-77;27:922-927.
187. Kay CR, Wingrave SJ. Oral contraceptives and rheumatoid arthritis. (Letter). Lancet 1983; 1:14-37.
188. Linos A, Worthington JW, O'Fallon WM, et al. The epidemiology of rheumatoid arthritis in Rochester, Minnesota: a study of incidence, prevalence, and mortality. Am J Epidemiol 1980; 111:87-98.
189. Royal College of General Practitioners' Oral Contraception Study. Reduction in incidence of rheumatoid arthritis associated with oral contraceptives. Lancet 1978;1:569-71.
190. del Junco DJ, Annegers JF, Luthra HS, et al. Do oral contraceptives prevent rheumatoid arthritis? JAMA 1985;254: 1938-1941.
191. Spector TD, Brown GC, Silman AJ. Increased rates of previous hysterectomy and gynaecological operations in women with osteoarthritis. BMJ 1988;297:899-900.
192. Spector TD, Perry LA, Tubb G, et al. Low free testosterone levels in rheumatoid arthritis. Ann Rheum Dis 1988;47: 65-68.
193. Cutolo M, Balleari E, Giusti M, et al. Sex hormone status in women suffering from rheumatoid arthritis. J Rheumatol 1986;13:1019-1023.
194. Samsioe G. Sexual endocrinology in older women. Acta Obstet Gynecol Scand Suppl 1987;140:23-27.
195. Stimson WH. Estrogen and human T lymphocytes: presence of specific receptors in T-suppressor/cytotoxic subset. Scand J Immunol 1988;28:345-350.
196. Novotny EA, Raveche ES, Sharrow S, et al. Analysis of thymocyte subpopulations following treatment with sex hormones. Clin Immunol Immunopathol 1983;28:205-217.
197. Polan ML, Daniele A, Kuo A. Gonadal steroids modulate human monocyte interleukin-1 (IL-1) activity. Fertil Steril 1988;49:964-968.
198. McKane WR, Khosla S, Peterson JM, et al. Circulating levels of cytokines that modulate bone resorption: effects of age and menopause in women. J Bone Miner Res 1994;9: 1313-18.
199. Dodge HJ, Mikkelsen WM, Duff IF. Age-sex specific prevalence of radiographic abnormalities of the joints of the hands, wrists, and cervical spine of adult residents of the Tecumseh, Michigan, Community Health Study area, 1962-1965. J Chronic Dis 1970;23:151-9.
200. Roberts J, Burch TA. Osteoarthritis prevalence in adults by age, sex, race, and geographic area: United States 1960-1962. Rockville, MD: US Department of Health, Education, and Welfare, Public Health Service, National Center for Health Statistics, 1966. (Vital and health statistics, series 1, vol 11, no. 15).
201. Lawrence JS. Rheumatism in populations. London, England: Heinemann Medical Books, 1977.
202. Schouten JSAG, van den Ouweland FA, Valkenburg HA. Natural menopause, oophorectomy, hysterectomy, and the risk of osteoarthritis of the dip joints. Scand J Rheumatol 1992;21:196-200.
203. Spector TD, Campion GD. Generalised osteoarthritis: a hormonally mediated disease. Ann Rheum Dis 1989;48:523-527.
204. Hannan MT, Felson DT, Anderson JJ, et al. Estrogen use and radiographic osteoarthritis of the knee in women: The Framingham Osteoarthritis Study. Arthritis Rheum 1990;33: 525-532.
205. Samanta A, Jones A, Regan M, et al. Is osteoarthritis in women affected by hormonal changes or smoking? Br J Rheumatol 1993;32:366-370.
206. Ley CJ, Lees B, Stevenson JC. Sex- and menopauseassociated changes in body-fat distribution. Am J Clin Nutr 1992;55:950-954.
207. Wing RR, Matthews KA, Kuller LH, et al. Weight gain at the time of menopause. Arch Intern Med 1991;151:97-102.
208. Aloia JF, McGowan DM, Vaswani AN, et al. Relationship of menopause to skeletal and muscle mass. Am J Clin Nutr 1991;53:1378-1383.