The Effects of Hydroxyl Radical Attack on Dopa, Dopamine, 6‐Hydroxydopa, and 6‐Hydroxydopamine

Pigment Cell Research

Volumn 8, Issue 6, 1995, Pages 283-293

  NAPPI, ANTHONY J ^a   VASS, EMILY ^a   PROTA, GIUSEPPE ^a   MEMOLI, SOFIA ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Catechols; Fenton reaction; Hydroxyl radical; Iron ions; Melanogenesis; Quinone; Reactive oxygen species; Salicylate hydroxylation; Semiquinone

Indexed keywords

6 HYDROXYDOPA; 6-HYDROXYDOPA; BENZOQUINONE DERIVATIVE; DOPA; DOPAMINE; DOPAQUINONE; DRUG DERIVATIVE; EUMELANIN; HYDROXYL RADICAL; MELANIN; OXIDOPAMINE; QUINONE DERIVATIVE;

ARTICLE; CHEMICAL MODEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; OXIDATION REDUCTION REACTION;

BENZOQUINONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIHYDROXYPHENYLALANINE; DOPAMINE; HYDROXYL RADICAL; MELANINS; MODELS, CHEMICAL; OXIDATION-REDUCTION; OXIDOPAMINE; QUINONES;

EID: 0029444567     PISSN: 08935785     EISSN: 16000749     Source Type: Journal    
DOI: 10.1111/j.1600-0749.1995.tb00676.x     Document Type: Article

References (59)

1. Oxygen free radicals and Parkinson's disease
2. Damage to the bases in DNA induced by hydrogen peroxide and ferric ion chelates
3. Selectivity of melanized nigra‐striatal dopamine neurons to degeneration in Parkinson's disease may depend on iron‐melanin interaction
4. Iron, melanin and dopamine interaction: relevance to Parkinson's disease
5. Photochemical reduction of ferric iron by chelators results in DNA strand breaks
6. Hydroxyl free radical ·OH) formation reflected by salicylate hydroxylation and neuromelanin: in vivo markers for oxidant injury of nigral neurons. Ann. New York Acad
7. +
8. Oxidative stress, glutamate, and neurodegenerative disorders
9. Implications of alterations in trace element levels in brain in Parkinson's disease and other neurological disorders affecting basal ganglia
10. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it
11. Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products. J. Biochem. Biophys
12. Effect of pH on the oxidation pathway of dopamine catalyzed by tyrosinase
13. 2
14. Altered brain metabolism of iron as a cause of neurodegenerative diseases
15. Neuromelanin‐containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study
16. Oxidative stress: a role in the pathogenesis of Parkinson's disease
17. The toxicity of melanin precursors
18. Superoxide dismutase and the Fenton chemistry. Reaction of ferric‐EDTA complex and ferric‐bipyridyl complex with hydrogen peroxide without the apparent formation of iron (II)
19. Oxidants and the central nervous system: Some fundamental questions
20. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
21. Free radical theory of aging
22. Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease
23. Selective vulnerability of pigmented dopaminergic neurons in Parkinson's disease
24. Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X‐ray microanalysis
25. The neurochemical basis of the pharmacology of Parkinson's disease
26. Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol‐inducible and other forms of rabbit liver microsomal cytochromes P‐450
27. Oxygen‐dependent conjugation of dopa with cysteine catalysed by iron‐EDTA complex
28. Superoxide dismutase enhances the formation of hydroxyl radicals in the reaction of 3‐hydroxyanthranilic acid with molecular oxygen
29. Iron‐melanin complex in substantia nigra of parkinsonian brains: an x‐ray microanalysis
30. What process causes nigral cell death in Parkinson's disease
31. Oxygen free radicals and brain dysfunction
32. Chemical intermediates in dopamine oxidation by tyrosinase, and kinetic studies of the process
33. Reaction between ortho‐semiquinone and oxygen: pulse radiolysis, electron spin resonance, and oxygen uptake studies
34. Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content
35. Detection of dopamine‐DNA adducts: potential role in Parkinson's disease
36. Identification of products and intermediates during L‐dopa oxidation to dopachrome using high pressure liquid chromatography with electrochemical detection
37. Effect of pH on the oxidation pathway of dopamine and dopa
38. The hydroxylation of phenylalanine and tyrosine: a comparison with salicylate and tryptophan
39. The hydroxylation of the salicylate anion by a Fenton reaction and T‐radiolysis: a consideration of the respective mechanisms
40. Cobalt(II) ion as a promoter of hydroxyl radical and possible ‘ctypto‐hydroxyl’ radical formation under physiological conditions. Differential effects of hydroxyl radical scavengers. Biochim. Biophys
41. Chromatographic analyses of the effects of glutathione, cysteine and ascorbic acid on the monophenol and diphenol oxidase activities of tyrosinase
42. The effects of glutathione and ascorbic acid on the oxidations of 6‐hydroxydopa and 6‐hydroxydopamine
43. Nonenzymatic conversion of 3,4‐dihydroxyphenylalanine to 2,4,5‐trihydroxyphenylalanine and 2,4,5‐trihydroxyphenyl‐alanine quinone in physiological solutions
44. An introduction to the free radical hypothesis on Parkinson's disease
45. The effect of melanin on iron associated decomposition of hydrogen peroxide
46. Determination of hydroxylated aromatic compounds produced in a superoxide‐dependent formation of hydroxyl radicals by liquid chromatography/electrochemistry
47. 2 in CCC‐PM2 bacteriophage DNA
48. Radicals in melanin biochemistry
49. Catalytic oxidation of 2,4,5‐trihydroxyphenylalanine by tyrosinase: identification and evolution of intermediates
50. Oxidation of 6‐hydroxydopamine catalyzed by tyrosinase
51. Neurotoxicity of methamphetamine and related drugs
52. Hydroxyl radical attack on dopamine
53. L‐DOPA increases nigral production of hydroxyl radicals in vivo: potential L‐DOPA toxicity
54. In patients receiving dopamine infusions for treatment of shock do free radicals convert dopamine to 6‐hydroxydopamine
55. Hydroxyl radical generation by a light‐dependent Fenton reaction
56. The role of iron in senescence of dopaminergic neurons in Parkinson's disease
57. The possible role of iron in the etiopathology of Parkinson's disease
58. Iron in brain function and dysfunction with emphasis on Parkinson's disease
59. The chemical characterization of melanin contained in substantia nigra of human brain