In vivo actions of IGF analogues with poor affinities for IGFBPs: Metabolic and growth effects in pigs of different ages and GH responsiveness

Progress in Growth Factor Research

Volumn 6, Issue 2-4, 1995, Pages 385-395

  Walton, P E ^a   Dunshea, F R ^b   Ballard, F J ^a  

^a Div of Hlth Sciences and Nutrition   (Australia)

^b VIC INSTITUTE OF ANIMAL SCIENCE   (Australia)

Author keywords

growth effects; growth hormone; IGF analogues; IGF binding proteins; IGF I; pigs

Indexed keywords

DRUG DERIVATIVE; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C;

AGING; ANIMAL; DRUG EFFECT; FEMALE; GROWTH; MALE; ORGAN SIZE; PHYSIOLOGY; REVIEW; SWINE;

AGING; ANIMALS; FEMALE; GROWTH; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MALE; ORGAN SIZE; SWINE;

EID: 0029432792     PISSN: 09552235     EISSN: None     Source Type: Journal    
DOI: 10.1016/0955-2235(95)00007-0     Document Type: Article

References (13)

1. Insulin-like growth factor-I stimulates growth in normal growing rats
2. Anabolic effects of insulin-like growth factor-I (IGF-I) and an IGF-I variant in normal female rats
3. Comparison of in vivo effects of insulin-like factors I and II and of growth hormone in hypophysectomized rats
4. Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats
5. IGF-I and its variant, des(1–3)IGF-I, enhance growth in rats with reduced renal mass
6. IGF-I and especially the truncated analog des(1–3)IGF-I enhance growth in rats following gut resection
7. IGI-I and many potent variants restore growth of diabetic rats without inducing all characteristic insulin effects
8. Modification of animal growth with growth hormone and insulin-like growth factors
9. Stimulation of pig growth performance by porcine growth hormone: determination of the dose-response relationship
10. Growth hormone increases insulin-like growth factor-I (IGF-I) and decreases IGF-II in plasma of growing pigs
11. Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency
12. Effects of porcine growth hormone and insulin-like growth factor-I (IGF-I) on immunoreactive IGF-binding protein concentration in pigs
13. Differences in the association of insulin-like growth factor-I (IGF-I) and IGF-I variants with rat, sheep, pig, human and chicken plasma-binding proteins