Antigen Presentation: Kissing cousins exchange CLIP

Current Biology

Volumn 5, Issue 12, 1995, Pages 1372-1376

  Sanderson, Frances ^a   Trowsdale, John ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; HLA ANTIGEN CLASS 2; HLA D ANTIGEN;

CHEMISTRY; HUMAN; INVARIANT CHAIN; METABOLISM; REVIEW;

ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HUMANS;

EID: 0029426741     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(95)00274-0     Document Type: Article

References (18)

1. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation
2. In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
3. Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules
4. Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphisms in class II
5. The structure of an intermediate in class II MHC maturation. HLA-DR3 complexed with the invariant chain fragment CLIP
6. HLA-DR and -DQ epitopes and monoclonal antibody specificity
7. A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides
8. A new human HLA class II-related locus, DM
9. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells
10. An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules
11. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments
12. Separation of subcellular compartments containing distinct functional forms of MHC class II
13. Mediation by HLA-DM of dissociation of peptides from HLA-DR
14. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading
15. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
16. Crystal structure at 2.2 å resolution of the MHC-related neonatal Fc receptor
17. Myelin basic protein peptide complexes with the class II MHC molecules I-A(U) and I-A(K) form and dissociate rapidly at neutral pH
18. A lysosomal targeting signal in the cytoplasmic tail of the β chain directs HLA-DM to MIIC class II compartments