Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

Neuroscience Letters

Volumn 202, Issue 1-2, 1995, Pages 17-20

  Blum Degena, Doris ^c   Müller, Thomas ^b   Kuhn, Wilfried ^b   Gerlach, Manfred ^a,b   Przuntek, Horst ^b   Riederer, Peter ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c NONE

Author keywords

Alzheimer's disease; Cerebrospinal fluid; Enzyme linked immunosorbent assay; Interleukin 1 ; Interleukin 2; Interleukin 6; Parkinson's disease; Plasma

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; NERVE DEGENERATION; PARKINSON DISEASE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-2; INTERLEUKIN-6; MALE; MIDDLE AGED; PARKINSON DISEASE;

EID: 0029417080     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(95)12192-7     Document Type: Article

References (39)

1. Interleukin-6 and a-2macroglobulin indicate an acute-phase state in Alzheimer's disease cortices
2. Stimulation of oligodendroglial proliferation and maturation by interleukin-2
3. Lymphokine production in patients with Alzheimer's disease
4. Cerebrospinal fluid interleukin-1 beta (IL-1 beta) in Alzheimer's disease and neurological disorders
5. Investigations on auto-antibodies in Alzheimer's and Parkinson's disease using defined neuronal cultures
6. Serum interleukin-2 levels in patients with dementia of the Alzheimer type
7. γδ+ T-cells are increased in patients with Parkinson's disease
8. On the cellular source and function of interleukin-6 produced in the central nervous system in viral diseases
9. Molecular mechanisms for neurodegeneration: synergism between reactive oxygen species calcium and excitotoxic amino acids
10. Interleukin-1 stimulation of astroglial proliferation after brain injury
11. InterIeukin-1 of the central nervous system is produced by ameboid microglia
12. Interleukin-1 is an astroglial growth factor in the developing brain
13. Interleukin 1 regulates synthesis of amyloid β-protein precursor mRNA in hu man endothelial cells
14. Brain interleukin 1 and S100 immunoreactivity are elevated in Down syndrome and Alzheimer's disease
15. Cerebral blood flow in dementia
16. Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal two-week-old rats in cultures
17. Parkinsonism: onset progression and mortality
18. Immune system-associated antigens on the surface of peripheral blood lymphocytes in patients with Alzheimer's disease
19. Presence of Tcytotoxic suppressor and leucocyte common-antigen-positive cells in Alzheimer disease brain tissue
20. Cytokine production by human fetal microglia and astrocytes
21. Interleukin-1 regulates synthesis of nerve growth factor in nonneuronal cells of rat sciatic nerve
22. 2-microglobulin with neuropeptides in cerebrospinal fluid of patients with dementia of the Alzheimer type
23. Immune functions in Parkinson's disease: lymphocyte subsets concanavalin A-induced suppressor cell activity and in vitro immunoglobulin production
24. Immune system response in Alzheimer's disease
25. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
26. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease
27. Interleukin-1β interleukin-6 epidermal growth factor and transforming growth factor-a are elevated in the brain from parkinsonian patients
28. Tumor necrosis factor-a (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
29. Reactive microglias are positive for interleukin-2 and -6 in an Alzheimer's dementia brain
30. Serum levels of interleukin-6 and acute phase response
31. Interleukins and the immune system 1
32. The decrease of CD8positive lymphocytes in Alzheimer's disease
33. 1-Antichymotrypsin and IL-1β are not increased in CSF or serum in Alzheimer's disease
34. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease
35. Induction of neuronal differentiation of PC12 cells by B cell stimulatory factor 2/interleukin 6
36. Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated acute phase response in the brain?
37. Interleukin 2: a class of T cell growth factors
38. 2-macroglobulin and C-reactive protein
39. Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins