[3H]‐L‐2‐amino‐4‐phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a

British Journal of Pharmacology

Volumn 116, Issue 8, 1995, Pages 3279-3287

  Eriksen, Lisbeth ^a   Thomsen, Christian ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

(1S,3R) 1 aminocyclopentane 1,3 dicarboxylate; cyclic AMP; guanine nucleotide shift; L 2 amino 4 phosphonobutyrate receptor; Metabotropic glutamate receptor binding; 3H L 2 amino 4 phosphonobutyrate

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRATE RECEPTOR; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 2-AMINO-4-PHOSPHONOBUTYRATE RECEPTOR; 2-AMINO-4-PHOSPHONOBUTYRIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; AMINOBUTYRIC ACID DERIVATIVE; CYCLIC AMP; METABOTROPIC RECEPTOR; TRITIUM; CALCIUM ION; CHLORIDE ION; CYCLOLEUCINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; GLYCINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); IBOTENIC ACID; MAGNESIUM ION; MANGANESE; PHOSPHOSERINE; QUISQUALIC ACID; RADIOLIGAND; RECEPTOR SUBTYPE;

ANIMAL; ARTICLE; BINDING COMPETITION; BIOSYNTHESIS; BRAIN; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; HAMSTER; METABOLISM; PH; TEMPERATURE; TIME; ANIMAL CELL; BINDING AFFINITY; BINDING SITE; CELL STRAIN BHK; CONTROLLED STUDY; GENETIC TRANSFECTION; ISOTOPE LABELING; LIGAND BINDING; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

AMINOBUTYRIC ACIDS; ANIMALS; BINDING, COMPETITIVE; BRAIN; CELLS, CULTURED; CRICETINAE; CYCLIC AMP; EXCITATORY AMINO ACID AGONISTS; HYDROGEN-ION CONCENTRATION; RECEPTORS, METABOTROPIC GLUTAMATE; TEMPERATURE; TIME FACTORS; TRITIUM;

EID: 0029416950     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1995.tb15136.x     Document Type: Article

References (41)

1. 3H]‐2‐amino‐4‐phosphonobutyrate to L‐glutamate‐sensitive sites on rat brain synaptic membranes
2. −3H]‐2‐Amino‐4‐phosphonobutyrate binding sites in the rat hippocampus: distribution and possible physiological role
3. Metabotropic glutamate receptor heterogeneity in rat brain
4. Muscarinic receptors: Characterization, coupling and function
5. 3H]APB binding
6. Model systems for the study of seven‐transmembranesegment receptors
7. Stimulation intensity as critical determinant of presynaptic receptor effectiveness
8. A novel metabotropic glutamate receptor expressed in retina and olfactory bulb
9. 2+‐dependent L‐glutamate binding do not correspond to 2‐amino‐4‐phosphonobutanate‐sensitive excitatory amino acid receptors
10. Presynaptic glutamate receptors depress excitatory monosynaptic transmission between mouse hippocampal neurones
11. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate‐receptor subtypes
12. Agonist analysis of 2‐(carboxycyclo‐propyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells
13. Partial agonists, full agonists, antagonists: Dilemmas of definition
14. Species differences in the G protein selectivity of the human and bovine A1‐adenosine receptor
15. L‐2‐amino‐4‐phosphonobutanoic acid and 1S,3R‐1‐aminocyclopentane‐1,3‐dicarboxylic acid reduce paired‐pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices
16. Micromolar L‐2‐amino‐4‐phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex
17. L‐AP4 receptor ligands
18. Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptors
19. Cloning and expression of an A1 adenosine receptor from rat brain
20. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system
21. 3H]2‐amino‐4‐phosphonobutyric acid and characterization of its binding to rat membranes: A selective ligand for the chloride/calcium dependent class of L‐glutamate binding sites
22. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L‐2‐amino‐4‐phosphonobutyrate
23. The ligand binding domain in metabotropic glutamate receptors belongs to a family of receptor structures related to bacterial periplasmic binding proteins
24. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction
25. Activity of conformationally rigid 2‐amino‐4‐phosphonobutanoic acid (AP4) analogue (RS)‐1‐amino‐3‐(phosphono‐methylene)cyclobutane‐1‐carboxylic acid (cyclobutylene AP5) on evoked responses in the perforant pathway of rat hippocampus
26. 3H]glutamate binding: a new receptor or a particular transport process?
27. Domains involved in the specificity of G‐protein activation in phospholipase C coupled metabotropic glutamate receptor
28. Trans‐ACPD and L‐APB presynaptically inhibit excitatory glutamergic transmission in the basolateral amygdala (BLA)
29. Chloride transport blockers inhibit the chloride‐dependent glutamate binding to rat brain membranes
30. 3H]APB) binding with methyl‐substituted APB analogues and glutamate agonists
31. Cloning and expression of a new member of the L‐2‐amino‐4‐phosphonobutyric acid‐sensitive class of metabotropic glutamate receptors
32. 3H]glutamate receptor binding in membranes
33. Functional characterization of metabotropic glutamate receptor subtypes
34. Molecular cloning, expression, and characterization of metabotropic glutamate receptor subtypes
35. Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4a
36. Effects of bromohomoibotenate on metabotropic glutamate receptors
37. Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family
38. L‐Glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L‐glutamate without direct activation of mGluR1a
39. L‐2‐Amino‐4‐phosphonobutyrate (L‐AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase
40. L‐Serine‐O‐phosphate has affinity for the type IV, but not the type I, metabotropic glutamate receptor
41. Characteristics of chloride‐dependent incorporation of glutamate into brain membranes argue against a receptor binding site