Uncoupling of GABAA/benzodiazepine receptor α1, β2, and γ2 subunit mRNA expression in cerebellar Purkinje cells of staggerer mutant Mmice

Journal of Neuroscience

Volumn 15, Issue 12, 1995, Pages 8121-8130

  Luntz Leybman, Vera ^a   Rotter, Andrej ^a   Zdilar, Darko ^a   Frostholm, Adrienne ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Cerebellum; Deep cerebellar nuclei; Development; GABA; In situ hybridization; Reeler; Weaver

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CEREBELLUM CORTEX; GENE EXPRESSION; GRANULE CELL; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PURKINJE CELL; AGING; ANIMAL; CEREBELLUM NUCLEUS; GENETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR PROBE; MOUSE MUTANT; NEWBORN; NUCLEOTIDE SEQUENCE; TISSUE DISTRIBUTION;

AGING; ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CEREBELLAR NUCLEI; IN SITU HYBRIDIZATION; MICE; MICE, NEUROLOGIC MUTANTS; MOLECULAR PROBES; MOLECULAR SEQUENCE DATA; PURKINJE CELLS; RECEPTORS, GABA-A; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 0029416908     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.15-12-08121.1995     Document Type: Article

References (71)

1. A receptor deduced from mutation-induced rectification. Neuroreport 5:285-288.
2. + RNA. Biotechniques 6:114-116.
3. 2/3-subunits. J Biol Chem 266:4478-4483.
4. A receptor subunit genes: relationship to human genetic disease. Neuron 3:647-654.
5. Buckwalter MS, Lossie AC, Scarlett LM, Camper SA (1992) Localization of the human chromosome 5q genes Gabra-1, Gabra-2, II-4, II-5, and Irf-1 on mouse chromosome 11. Mamm. Genome 3:164-607.
6. A receptor oligomer. J Biol Chem 261:15013-15016.
7. Crepel FJ, Delhaye-Bouchaud N, Guastavino J, Sampaio I (1980) Multiple innervation of cerebellar Purkinje cells by climbing fibers in staggerer mutant mouse. Nature 283:483-484.
8. Crepel FJ, Dupont J-L, Gardette R (1984) Selective absence of Calcium spikes in Purkinje cells of staggerer mutant mice in cerebellar slices maintained in vitro. J Physiol (Lond) 346:111-125.
9. 1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics 12:801-806.
10. - channel complex. J Neurosci 8:602-614.
11. Danciger M, Farber DB, Kozal CA (1993) Genetic mapping of three GABAA receptor subunit genes in the mouse. Genomics 16:361-365.
12. A receptor γ2 1-15 Cys antibodies. J Neurochem 58:72-77.
13. Edelman GM, Chuong CM (1982) Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice. Proc Natl Acad Sci USA 79:7036-7040.
14. Frantz GD, Tobin AJ (1990) The use of in situ hybridization to study gene expression in mouse neurological mutants. In: In situ hybridization histochemistry (Chesselet M-F, ed), pp 71-110. Boca Raton: CRC.
15. Fritschy J-M, Benke D, Mertens S, Oertel WH, Bachi T, Mohler H (1992) Five subtypes of type γ-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc Natl Acad Sci USA 89:6726-6730.
16. A-receptor subtypes during postnatal development: an immunohistochemical study. J Neurosci 14:5302-5324.
17. 1 subunit mRNA expression in reeler mouse cerebellar Purkinje cells during postnatal development. Dev Brain Res 64:121-128.
18. Fuchs K, Sieghart W (1989) Evidence for the existence of several different α and β subunits of the GABA/benzodiazepine receptor complex from rat brain. Neurosci Lett 97:329-333.
19. D1α in cerebellar Purkinje cells. Its specific absence in mouse mutants with Purkinje cell abnormality and altered immunoreactivity in response to conjunctive stimuli causing long term desensitization. J Biol Chem 269:32418-32425.
20. A receptor messenger RNA expression in the deep cerebellar nuclei of Purkinje cell degeneration mutants is maintained following the loss of innervating Purkinje neurons. Neuroscience 52:63-71.
21. Green MC, Lane PW (1967) Linkage group II of the house mouse. J Hered 58:225-228.
22. A receptor in the rat brain. J Neurosci 14:7168-7179.
23. A receptors in the plasma membrane of cultured cerebellar granule cells: an immunocytochemical study. Neurosci Lett 124:162-165.
24. Hendelman WJ, Aggerwal AS (1980) The Purkinje neuron. I. A Golgi study of its development in mouse and in culture. J Comp Neurol 193:1063-1079.
25. Herrup K, Mullen RJ (1979a) Staggerer chimaeras: intrinsic nature of Purkinje cell defects and implications for normal cerebellar development. Brain Res 178:443-457.
26. Herrup K, Mullen RJ (1979b) Regional variation and absence of large neurons in the cerebellum of the staggerer mouse. Brain Res 172:1-12.
27. 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis. Genomics 20:285-288.
28. 2L subunit on the modulation of responses to GABAA receptor activation. Br J Pharmacol 108:711-716.
29. Jan YN, Jan LY (1993) Functional gene cassettes in development. Proc Natl Acad Sci USA 90:8305-8307.
30. Kalvakolanu DVR, Livingston WH III (1991) Rapid and inexpensive protocol for generating >95% recombinants in subcloning experiments. BioTechniques 10:176-177.
31. 1 receptor gene. Genomics 9:390-395.
32. A/benzodiazepine receptors. J Neurochem 63: 1466-1476.
33. Kim HY, Sapp DW, Olsen RW, Tobin AJ (1993) GABA alters GABAA receptor mRNAs and increases ligand binding. J Neurochem 61: 2334-2337.
34. A-receptor confers sensitivity to benzodiazepine receptor ligands. FEBS Lett 293:191-194.
35. 2-subunit in mice by alternative splicing. J Neurochem 56:713-715.
36. Landis DMD, Sidman RL (1978) Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice. J Comp Neurol 179:831-864.
37. Larramendi LMH (1969) Analysis of synaptogenesis in the cerebellum of the mouse In: Neurobiology of cerebellar evolution and development (Llinas R, ed), pp 803-843. Chicago: Am Med Assoc Educ Res Fd.
38. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 12:1063-1076.
39. 2 subunit gene expression in the developing normal and mutant mouse cerebellum. Mol Brain Res 191:9-21.
40. A receptor channels. Annu Rev Neurosci 17:569-602.
41. Messer A (1988) Thyroxine injections do not cause premature induction of thymidine kinase in sg/sg mice. J Neurochem 51:888-891.
42. Messer A, Savage M, Carter TP (1981) Thymidine kinase activity is reduced in the developing staggerer cerebellum. J Neurochem 37: 1610-1612.
43. Messer A, Eisenberg B, Martin DL (1988) Role of timing and cell interactions in cerebellar development. In: Disorders of the developing nervous system: changing views of their origins, diagnosis, and treatment (Swann JW, Messer A, eds), pp 111-123. New York: Liss.
44. Messer A, Plummer J, Eisenberg B (1990) Staggerer mutant mouse Purkinje cells do not contain detectable calmodulin mRNA. J Neurochem 55:293-302.
45. Messer A, Eisenberg B, and Plummer J (1991) The lurcher cerebellar mutant phenotype is not expressed on a staggerer mutant background. J Neurosci 11:2295-2302.
46. A receptor gene expression. Mol Pharmacol 42: 415-422.
47. Mhatre MC, Pena G, Sieghart W, Ticku MK (1993) Antibodies specific for GABAA receptor α subunits reveal that chronic alcohol treatment down-regulates α-subunit expression in rat brain regions. J Neurochem 61:1620-1625.
48. 3 subunit mRNAs as well as poly-peptide expression in primary cultured cerebral cortical neurons. Mol Brain Res 24:159-165.
49. 14C-leucine and phosphorylation. Dev Neurosci 2:179-287.
50. A receptor α subunit mRNAs in embryonic chick neurons in culture. J Biol Chem 266:6011-6014.
51. 6 subunit mRNA levels in rat cerebellum. Mol Cell Neurosci 3:251-258.
52. A receptor subunit polypeptides increase in parallel but exhibit distinct distributions in the developing rat cerebellum. J Neurobiol 25:1533-1544.
53. A receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature 364:448-450.
54. A receptor determined by electron microscopic image analysis. J Neurochem 62:815-818.
55. 3 subtypes. Mol Pharmacol 43:801-806.
56. A receptor subunit for benzodiazepine pharmacology. Nature 338:582-585.
57. Roffler-Tarlov S, Herrup K (1981) Quantitative examination of the deep cerebellar nuclei in the staggerer mouse. Brain Res 215:49-59.
58. Rotter A, Frostholm A (1988) Cerebellar benzodiazepine receptors: cellular localization and consequences of neurological mutations in mice. Brain Res 444:133-146.
59. A receptors in mice with mutations affecting the structure and connectivity of the mouse cerebellum. Brain Res 439:236-248.
60. A receptor isoform. Genomics 23:528-533.
61. Sidman RL (1968) Development of interneuronal connections in brains of mutant mice In: Physiological and biochemical aspects of nervous integration (Carlson FD, ed), pp 163-193. Englewood Cliffs, NJ: Prentice Hall.
62. Sigel E, Stephenson FA, Mamalaki C, Barnard EA (1983) A γ-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex. J Biol Chem 258:6965-6971.
63. Sotelo C, Wassef F (1991) Purkinje cell heterogeneity in four cerebellar mutations revealed by zebrin I expression. Soc Neurosci Abstr 17: 918.
64. A receptors In: Handbook of receptors and channels, Ligand and voltage-gated ion channels (Norton RA, ed), pp 265-289 Boca Raton: CRC.
65. A receptors: Comparison in seizure-prone and -resistant mice and during development. J Mol Neurosci 3:177-184.
66. 2 subunits of the γ-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome. Proc Natl Acad Sci USA 89:5857-5861.
67. A/benzodiazepine receptor subunit mRNAs and ligand binding sites in mouse cerebellar neurons following in vivo ethanol administration: an autoradiographic analysis. J Neurochem 65:1229-1239.
68. A receptor β subunit heterogeneity: functional expression of cloned cDNAs. EMBO J 8:1665-1670.
69. Yuasa S, Kawamura K, Ono K, Yamakuni T, Yasuo T (1991) Development and migration of Purkinje cells in the mouse cerebellar primordium. Anat Embryol 184:195-212.
70. 3H]flunitrazepam binding sites during postnatal development of mouse cerebellum. Dev Brain Res 61:63-71.
71. 3 subunit mRNAs in the developing mouse cerebellum. J Comp Neurol 326: 580-594.