l-N6-(1-Iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo

European Journal of Pharmacology

Volumn 294, Issue 2-3, 1995, Pages 703-712

  Stenger, Steffen ^a   Thüring, Heike ^a   Röllinghoff, Martin ^a   Manning, Pamela ^b   Bogdan, Christian ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b PFIZER INC   (United States)

Author keywords

Aminoguanidine; l N6 (1 Iminoethyl) lysine; Leishmaniasis; NG Monomethyl l arginine; Nitric oxide (NO); Nitric oxide (NO) synthase, inducible

Indexed keywords

6 N (1 IMINOETHYL)LYSINE; AMINOGUANIDINE; ISOENZYME; N(G) METHYL DEXTRO ARGININE; N(G) METHYLARGININE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE METHYL ESTER; NEW DRUG; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; RECOMBINANT GAMMA INTERFERON; UNCLASSIFIED DRUG; ARGININE; DRUG DERIVATIVE; ENZYME INHIBITOR; LYSINE; N(6) (1 IMINOETHYL)LYSINE; N(6)-(1-IMINOETHYL)LYSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; EXPERIMENTAL INFECTION; FEMALE; FLUID INTAKE; FOOD INTAKE; ISOMER; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; WEIGHT REDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; ENZYMOLOGY; MACROPHAGE;

ANIMALS; ARGININE; CELLS, CULTURED; ENZYME INHIBITORS; FEMALE; LEISHMANIASIS; LYSINE; MACROPHAGES; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE;

EID: 0029415193     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00618-4     Document Type: Article

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