Interleukin‐2 Deficient Mice: A New Model to Study Autoimmunity and Self‐Tolerance

Immunological Reviews

Volumn 148, Issue 1, 1995, Pages 35-44

  HORAK, IVAN ^a   Lohler, Jurgen ^b   MA, AVERIL ^c   SMITH, KENDALL A ^d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNE HEMOLYTIC ANEMIA; AUTOIMMUNITY; CELL COMMUNICATION; CELLULAR IMMUNITY; DISSEMINATED CANCER; GRAFT REJECTION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; MUTAGENESIS; NONHUMAN; ONTOGENY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; ULCERATIVE COLITIS; ANIMAL; DISEASE MODEL; IMMUNOLOGY;

ANIMALS; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; HUMANS; INTERLEUKIN-2; MICE; SELF TOLERANCE;

EID: 0029414785     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1995.tb00092.x     Document Type: Article

References (29)

1. Antiviral immune responses in mice deficient for both interleukin–2 and interleukin–4
2. New lymphokine, provisionally designated interleukin T and produced by a human adult T cell leukemia line, stimulates T–cell proliferation and the induction of lymphokine‐activated killer cells
3. Defective lymphoid development in mice lacking expression of the common cytokine receptor y chain
4. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus
5. Cytokines as mediators of organ graft rejection and tolerance
6. Mouse models of IBD
7. Multifactorial nature of human immunodeficiency virus disease: Implications for therapy
8. Utilization of the β and γ chains of the IL–2 receptor by the novel cytokine IL–15
9. Cytokine signal transduction
10. Sharing of the interleukin‐2 (IL‐2) receptor chain between receptors for IL‐2 and IL‐4
11. Thymic selection and peptide‐induced activation of T‐cell receptor transgenic CD8 T cells in interleukin‐2 deficient mice
12. Interleukin‐10‐deficient mice develop chronic enterocolitis
13. Immune responses in inlerleukin‐2 deficient mice
14. T cells, but not B cells, are required for bowel inflammation in IL‐2 deficient mice
15. Spontaneous development of inflammatory bowel disease in T‐cell receptor mutant mouse
16. Interleukin‐2 receptor γ chain: A functional component of the interleukin‐7 receptor
17. Pleiotropy and redundancy: T cell derived lymphokines in the immune response
18. Interleukin‐2 receptor γ chain: A functional component of the interleukin‐4 receptor
19. Immunotherapy of cancer using interleukin‐ 2
20. Ulcerative colitis‐like disease in mice with a disrupted interleukin‐2 gene
21. Development and function of lymphocytes in mice deficient for both interleukins 2 and 4
22. + T cells
23. Development and function of T cells in mice rendered interleukin‐2 deficient by gene targeting
24. RAG‐2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
25. Interleukin‐2: Inception, impact, and implications
26. II‐2 knockout recipient mice reject islet cell allografts
27. Theoretical and experimental approaches to generalized autoimmunity
28. The IL‐2/IL‐2 receptor system: A current overview
29. Site‐directed mutagenesis by gene targeting in mouse embryo‐derived stem cells