The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes

Journal of Pineal Research

Volumn 19, Issue 4, 1995, Pages 178-188

  Sainz, Rosa M ^a   Mayo, Juan C ^a   Uría, Higinio ^a   Kotler, Mónica ^a   Antolfn, Isaac ^a   Rodriguez, Carmen ^a   Menendez‐Pelaez†, Armando ^a  

^a UNIVERSIDAD DE OVIEDO   (Spain)

Author keywords

apoptosis; melatonin; thymus

Indexed keywords

ANTIOXIDANT; DNA; MELATONIN;

AGING; ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; METABOLISM; PATHOLOGY; PHYSIOLOGY; PINEAL BODY; RAT; SCANNING ELECTRON MICROSCOPY; T LYMPHOCYTE; WISTAR RAT;

AGING; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; DNA; MELATONIN; MICROSCOPY, ELECTRON, SCANNING; PINEAL GLAND; RATS; RATS, WISTAR; T-LYMPHOCYTES;

EID: 0029401471     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.1995.tb00187.x     Document Type: Article

References (68)

1. Redox regulation of Fos and Jun DNA‐binding activity in vitro
2. Melatonin receptors in purified cell nuclei of liver
3. Nitric oxide‐mediated apoptosis in murine peritoneal macrophages
4. Porphyrin accumulation in the Harderian glands of female Syrian hamster results in mitrochondrial damage and cell death
5. Apoptosis: mechanisms and roles in pathology
6. Role of the pineal gland in seasonal reproductive function in mammals
7. Melatonin stimulates brain glutatione peroxidase activity
8. Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily
9. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid
10. Melatonin in oncology
11. Apoptosis and diseases
12. Effects of melatonin on vertebrate circa‐dian systems
13. The generation of hydrogen peroxide, superoxide radical and hydroxyl radical by 6‐hydroxydopamine, dialuric acid and related cytotoxic agents
14. Glucocorticoids activation of a calcium‐dependent endonuclease in thymocyte nuclei leads to cell death
15. Expression and involvement of c‐fos and c‐jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines
16. Apoptosis and DNA degradation induced by l‐methyl‐4‐phenylpyridinium in neurons
17. Expression cloning of a high‐affinity melatonin receptor from Xenopus dermal melanophores
18. Expression of bcl‐2 in Burkitt's lymphoma cell lines: induction by latent Eptein‐Barr virus genes
19. Prevention of programmed cell death of sympathetic neurons by the bcl‐2 protooncogene
20. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
21. Transcriptional overexpression of the proto‐oncogene bcl‐2 in patients with systemic lupus eritematosus
22. Hydroxy 1 radical production and lipid peroxidation parallels selective postischemic vulnerability in gerbil brain
23. Reactive oxygen species and the central nervous system
24. The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances
25. Cell death and the cell cycle: a relationship between transformation and neurodegeneration
26. Bcl‐2 is an inner mitochondrial membrane protein that blocks programmed cell death
27. Bcl‐2 functions in an antioxidant pathway to prevent apoptosis
28. P53 mutations in human cancer
29. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
30. Bcl‐2 blocks apoptosis in cells lacking mitochondrial DNA
31. Apoptosis
32. Bcl‐2 initiates a new category of oncogenes: regulators of cell death
33. Effect of the changes of epiphysial functions on the central and peripheral immune system in mice
34. The P53 tumor supressor gene
35. Melatonin shifts human circadian rhythms according to a phase‐response curve
36. Apoptosis is induced by B‐amyloid in cultured central nervous system neurons
37. 125I) melatonin by partially purified membranes of rat thymus
38. The immuno‐recon‐stituting effect of melatonin or pineal grafting and its relation to Zn pool in aging mice
39. The immunoneuroendocrine role of melatonin
40. Hematopoietic rescue via T‐cell‐dependent, endogenous GM‐CSF by the pineal neurohormone melatonin in tumor bearing mice
41. Colony‐stimulating activity and hematopoietic rescue from cancer chemotherapy compounds are induced by melatonin via endogenous interleukin‐4
42. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
43. 125I] melatonin by rat thymus membranes during postnatal development
44. Programmed death of autoreactive thymocytes
45. Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization
46. Melatonin modulation of estrogen receptor expression in MCF‐7 human breast cancer cells
47. The helix‐loop‐helix leucine repeat transcription factor can be functionally regulated in a redox‐dependent manner
48. Biochemical characteristics of melatonin receptors in different organs and translation of hormonal signal in the nucleus
49. Pineal control of aging: effect of melatonin and pineal grafting on aging mice
50. Melatonin, hydroxyl radical‐mediated oxidative damage and aging: a hypothesis
51. Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum
52. The pineal and its hormones in the control of reproduction in mammals
53. Neuroendocrinology of melatonin
54. Antioxidant capacity of melatonin: a novel action not requiring a receptor
55. Melatonin, free radicals and cancer initiation
56. Oxidative processes and antioxidative defense mechanisms in the aging brain
57. A review of the evidence supporting melatonin's role as an antioxidant
58. Internucleosomal deoxyribonucleic acid cleavage activity in apoptotic thymocytes: detection and endocrine regulation
59. Antibodies to CD3/TCR complex induce death by apoptosis in immature T cells in thymic culture
60. Melatonin receptors: current status, facts and hypotheses
61. Melatonin. A coordinating signal for mammalian reproduction
62. Melatonin: a potent, endogenous hydroxyl radical scavenger
63. Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation
64. Monoclonal antibody‐mediated tumor regression by induction of apoptosis
65. Photooxidation of melatonin
66. Transient hypertrophy of the ventral prostate and coagulating glands and accelerated thymic involution following pinealectomy in the mouse
67. Cell death: the significance of apoptosis