In vitro selection of RNA-based irreversible inhibitors of human neutrophil elastase

Chemistry and Biology

Volumn 2, Issue 11, 1995, Pages 741-750

  Smith, Drew ^a   Kirschenheuter, Gary P ^a   Charlton, Josephine ^a   Guidot, David M ^b   Repine, John E ^b  

^a GILEAD SCIENCES   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

acute respiratory distress syndrome; animal models; elastase; protease inhibitors; SELEX

Indexed keywords

ANIMALIA;

CATHEPSIN; CATHEPSIN G; LEUKOCYTE ELASTASE; OLIGONUCLEOTIDE; RNA; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; ARTICLE; CHEMISTRY; CROSS REACTION; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; MOLECULAR GENETICS; NEUTROPHIL; NUCLEOTIDE SEQUENCE; ORGAN SIZE; PATHOLOGY; PHYSICAL CHEMISTRY; POLYMERASE CHAIN REACTION; RAT; SYNTHESIS;

ANIMALS; BASE SEQUENCE; CATHEPSINS; CHEMISTRY, PHYSICAL; CROSS REACTIONS; HUMANS; LEUKOCYTE ELASTASE; MOLECULAR SEQUENCE DATA; NEUTROPHILS; OLIGONUCLEOTIDES; ORGAN SIZE; POLYMERASE CHAIN REACTION; RATS; RESPIRATORY DISTRESS SYNDROME, ADULT; RNA; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 0029395440     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-5521(95)90102-7     Document Type: Article

References (28)

1. Exploring molecular diversity with combinatorial shape libraries
2. Deconvolution of combinatorial libraries for drug discovery: a model system
3. Tagged versus untagged libraries: methods for the generation and screening of combinatorial chemical libraries
4. Oligonucleotides as research, diagnostic, and therapeutic agents
5. Diversity of oligonucleotide functions
6. Proteases — structures, mechanism and inhibitors
7. Proteolysis-induced pathomechanisms in acute inflammation and related therapeutic approaches
8. The role of neutrophil elastase in chronic inflammation
9. Scientific perspectives on adult respiratory distress syndrome
10. Synthetic inhibitors of elastase
11. Irreversible inhibition of serine proteases by peptidyl derivatives of alpha-aminoalkyl-phosphonate diphenyl esters
12. Irreversible inhibition of serine proteases by peptide derivatives of (alpha-aminoalkyl)phosphonate diphenyl esters
13. Modified RNA sequence pools for in vitro selection
14. Inhibition of human neutrophil elastase by polyguanylic acid and other synthetic polynucleotides
15. Improved predictions of secondary structures for RNA
16. DNA binds neutrophil elastase and mucus proteinase inhibitor and impairs their functional activity
17. Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84 Å resolution
18. Adverse effects of neutrophils on the lung
19. Neutrophils and neutrophil—endothelial cell adhesion in adult respiratory distress syndrome
20. Interleukin-1α-induced lung neutrophil accumulation and oxygen metabolite mediated lung leak in rats
21. Intratracheal but not intravascular interleukin-1 causes acute edematous injury in isolated neutrophil-perfused rat lungs through an oxygen radical-mediated mechanism
22. Neutrophil derived oxygen metabolites stimulate thromboxane release, pulmonary artery pressure increases, and weight gains in isolated perfused rat lungs
23. Modern metabolism as a palimpsest of the RNA world
24. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
25. The behavior and significance of slow-binding enzyme inhibitors
26. Tight-binding inhibitors — I. Kinetic behavior