Intracellular signaling by growth factors

Metabolism

Volumn 44, Issue SUPPL. 4, 1995, Pages 24-32

  Seedorf, Klaus ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH PROMOTOR; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN TYROSINE KINASES;

ANIMAL; ENZYME SPECIFICITY; FEEDBACK SYSTEM; HUMAN; INTRACELLULAR MEMBRANE; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; TIME;

ANIMAL; FEEDBACK; GROWTH SUBSTANCES; HUMAN; INTRACELLULAR MEMBRANES; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 0029393951     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/0026-0495(95)90217-1     Document Type: Article

References (89)

1. Signal transduction by receptors with tyrosine kinase activity
2. Growth factor signaling by receptors tyrosine kinases
3. Signalling by receptor tyrosine kinases
4. SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins
5. Binding of high affinity phosphotyrosyl peptide to the srcSH2 domain: Crystal structures of the complexed and peptide free form
6. SH2 and SH3 domains
7. Binding of SH2 domains of PLC gamma 1, GAP, and src to activated growth factor receptors
8. The tyrosine phosphorylated carboxy terminus of the EGF receptor is a binding site for GAP and PLCγ
9. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation
10. Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
11. SH2 domains of the p85α subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors
12. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
13. The SH2 and SH3-containing protein GRB2 links receptor tyrosine kinases to ras signaling
14. SH2 and SH3 containing Nck protein is oncogenic and a common target for different surface receptors
15. Individual EGF-R autophosphorylation sites do not stringently define association motifs for several SH2-containing proteins
16. Association of Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
17. Tyrosine 785 is a major determinant of Trk-substrate interaction
18. Neuronal differentiation signals are controlled by nerve growth factor receptor/trk binding sites for SHC and PLCγ
19. Insulin action, diabetogenes, and the cause of type II diabetes
20. The role of insulin receptor autophosphorylation in signal transduction
21. Crystal structure of the tyrosine kinase domain of the human insulin receptor
22. Structure of the insulin receptor substrate IRS1 defines a unique signal transduction protein
23. Identification of SHC as a substrate of the insulin receptor kinase distinct from the GAP-associated 62 kDa tyrosine phosphoprotein
24. Hepatocyte plasma membrane ecto-ATPase (ppl20/HA4) is a substrate for tyrosine kinase activity of the insulin receptor
25. Role of p85 subunit of phosphatidylinositol-3-kinase as an adapter molecule linking the insulin receptor, p62, and GTPase-activating protein
26. The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase
27. Mechanisms of insulin action
28. MAP kinase regulation—The oncogene connection
29. MAP kinase and the activation of quiescent cells
30. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
31. The SH2 and SH3 domains of mammalian Grb2 couple the EGF-R to the Ras activator mSos1
32. GRB2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras
33. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to ras signalling
34. Epidermal growth factor regulates p2lras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
35. The function of Grb2 in linking the insulin receptor to Ras signaling pathways
36. The SH2/SH3 domain containing protein Grb2 interacts with tyrosine-phosphorylated IRS1 and SHC: Implications for insulin control of ras signalling
37. An SH3-SH2-SH3 protein is required for p2lRasl activation and binds to sevenless and Sos proteins in vitro
38. Binding of Ras activator son of sevenless to insulin receptor substrate 1 signaling complex
39. The Sos (SON of sevenless)
40. Mammalian Ras interacts directly with the serine/threonine kinase Raf
41. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
42. How receptor tyrosine kinases activate ras
43. A new function for a phosphotyrosine phosphatase: Linking Grb2-Sos to a receptor tyrosine kinase
44. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
45. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
46. Inositol phospholipids-specific phospholipase C: Interaction of the gamma isoform with tyrosine kinases
47. Activation of the c-raf protein kinase by protein kinase C phosphorylation
48. Protein kinase C alpha activates raf-1 by direct phosphorylation
49. Signal transduction via MAP kinases: Proceed at your own RSK
50. PHAS-1 as a link between mitogen activated protein kinase and translation initiation
51. Rapamycin-FKBP specifically blocks growth dependent activation of and signaling by the 70 kD S6 protein kinase
52. PDGF- and insulin-dependent pp70S6K activation mediated by phosphatidylinositol-3-OH kinase
53. A mammalian protein targeted by G1-arresting rapamycin-receptor complex
54. Oncogenes and signal transduction
55. Phosphatidylinositol-3-OH kinase as a direct target of ras
56. The phosphatidylinositol-3 kinase is a dual specific enzyme: Autoregulation by an intrinsic serine kinase activity
57. The phosphatidylinositol 3 kinase serine kinase phosphorylates IRS1
58. A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole
59. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
60. Essential role of phosphatidylinositol 3 kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
61. Neurotrophin receptors: A window into neuronal differentiation
62. Platelet-derived growth factor: Mechanism of action and possible in vivo function
63. Rat brain capillary endothelial cells express functional PDGF-B-type receptors
64. Functional PDGFβ receptors on rat neuronal cells suggest neurotrophic activity of PDGF
65. Protein tyrosine kinase growth factor receptors and their ligands in development, differentiation, and cancer
66. Analysis of platelet-derived growth factor receptor domain function using a novel chimeric receptor approach
67. HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor
68. Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors
69. Growth factor signaling: Where is the specificity?
70. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells
71. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
72. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells
73. Signaling through SH2 and SH3 domains
74. Protein kinase C isoenzymes: Divergence in signal transduction
75. The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation
76. A divergence in the MAP kinase regulatory network defined by MEK kinase and raf
77. Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor
78. Phosphorylation of the erbB gene product from an avian erythroblastosis virus-transformed chicken fibroblast cell line
79. Effects of substitution of threonine 654 of the epidermal growth factor receptor on epidermal growth factor-mediated activation of phospholipase C
80. Molecular basis of insulin receptor function
81. Tumor-promoting phorbol esters increase the Km of the ATP-binding site of the insulin-receptor-associated tyrosine kinase from rat adipocytes
82. Catecholamines and tumor promoting phorbol ester inhibit insulin receptor kinase and induce insulin resistance in isolated human adipocytes
83. Protein kinase C: Mediator or inhibitor of insulin action?
84. Overexpression of protein kinase C isoenzymes alpha, beta 1, gamma and epsilon in cells overexpressing the insulin receptor: Effects on receptor phosphorylation and signaling
85. Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells
86. Pathway of phospholipase C activation initiated with platelet-derived growth factor is different from that initiated with vasopressin and bombesin
87. Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
88. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: Identification of tyr.992 as the high affinity binding site for SH2 domains of PLCγ
89. Functional studies on the EGF-receptor with an antibody that recognizes the intracellular portion of the receptor