Mitomycin C: small, fast and deadly (but very selective)

Chemistry and Biology

Volumn 2, Issue 9, 1995, Pages 575-579

  Tomasz, Maria ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; CROSS LINKING REAGENT; DNA; MITOMYCIN;

CHEMISTRY; DRUG EFFECT; REVIEW;

ANTIBIOTICS, ANTINEOPLASTIC; CROSS-LINKING REAGENTS; DNA; MITOMYCIN;

EID: 0029360580     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-5521(95)90120-5     Document Type: Short Survey

References (30)

1. Crosslinking of DNA by enzymatic or activated mitomycins and porfiromycins, bifunctionally‘alkylating’ antibiotics
2. Novel interstrand crosslinks induced by the antitumor antibiotic carzinophillin/azinomycin B
3. Bioactivation as a model for drug design. Bioreductive alkylation
4. Reductive metabolism and alkylation activity of mitomycin C induced by rat liver microsomes
5. Studies concerning the mechanism of electrophilic substitution reactions of mitomycin C
6. On the characterization of intermediates in the mitomycin activation cascade a practical synthesis of an aziridinomitosene
7. Isolation and structure of a covalent crosslink adduct between mitomycin C and DNA
8. Mitomycin C: a prototype bioreductive agent
9. Bioreductive alkylation as a trigger for toxic effects of dynemicin
10. SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumors
11. Reaction of DNA with chemically or enzymatically activated mitomycin C: isolation and structure of the major covalent adduct
12. Isolation and structure of an intrastrand crosslink adduct of mitomycin C and DNA
13. Isolation and characterization of a major adduct between mitomycin C and DNA
14. Adducts of mitomycin C and DNA in EMT6 mouse mammary tumor cells: effects of hypoxia and dicumarol on adduct patterns
15. Binding of mitomycin C to a dinucleoside phosphate and DNA
16. Conformations of complexes between mitomycins and decanucleotides. 3. Sequence specificity, binding at C-10, and mitomycin analogs
17. Structural, conformational and theoretical binding studies of antitumor antibiotic porfiromycin, a covalent binder of DNA, by X-ray, NMR, and molecular mechanics
18. NMR and computational characterization of mitomycin crosslinked to adjacent deoxyguanosines in the minor groove of the d(T-A-C-G-T-A).d(T AC-G-TA) duplex
19. Solution structure of the monoalkylated mitomycin C-DNA complex
20. Studies on the bonding specificity for mitomycin C-DNA monoalkylation processes
21. Recognition of specific DNA sequences by mitomycin C for alkylation
22. DNA sequence specificity of mitomycin crosslinking
23. Determination of the DNA crosslinking sequence specificity of reductively activated mitomycin C at single nucleotide resolution: deoxyguanosine residues at CpG are crosslinked preferentially
24. Recognition between mitomycin C and specific DNA sequences for crosslink formation
25. On the origins of the DNA sequence selectivity of mitomycin monoalkylation transformations
26. Binding of 27-diaminomitosene to DNA model for the precovalent recognition of DNA by activated mitomycin C
27. Alkylation and cross-linking of DNA by the unnatural enantiomer of mitomycin C: mechanism of the DNA-sequence specificity of mitomycins
28. Reaction of acid-activated mitomycin C with calf thymus DNA and model guanines. Elucidation of the base-catalyzed degra dation of N7-alkylguanine nucleosides
29. Sequence preferences of DNA interstrand crosslinking agents: importance of minimal DNA structural reorganization in the crosslinking reactions of mechlorethamine, cisplatin and mitomycin C
30. nC) in synthetic oligonucleotide duplexes