Long-circulating blood pool imaging agents

Advanced Drug Delivery Reviews

Volumn 16, Issue 2-3, 1995, Pages 335-348

  Bogdanov Jr , Alexei A ^a   Weissleder, Ralph ^a   Brady, Thomas J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chelate; Contrast agent; Gadolinium; Graft copolymer; Paramagnetic; Poly(ethylene glycol)

Indexed keywords

BLOOD; COLLOIDS; COMPUTERIZED TOMOGRAPHY; GADOLINIUM; GRAFT COPOLYMERS; MACROMOLECULES; MEDICAL APPLICATIONS; MEDICAL IMAGING; PARAMAGNETISM; POLYETHYLENE GLYCOLS; RADIOLOGY; TOXICITY;

BIOLOGICAL PROPERTIES; CHELATE; IMMUNOGENICITY; LONG-CIRCULATING BLOOD POOL IMAGING AGENTS; SCINTIGRAPHY;

CONTRAST MEDIA;

CHELATING AGENT; CONTRAST MEDIUM; COPOLYMER; DIAGNOSTIC AGENT; GADOLINIUM; MACROGOL; PENTETIC ACID; TECHNETIUM 99M;

BLOOD POOL SCINTISCANNING; CANCER; CARDIOVASCULAR DISEASE; CIRCULATION TIME; COVALENT BOND; DRUG DISTRIBUTION; DRUG HALF LIFE; IMAGING; IMMUNOGENICITY; INTERMETHOD COMPARISON; MACROMOLECULE; MAGNETIC RESONANCE ANGIOGRAPHY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; TECHNIQUE;

EID: 0029360319     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0169-409X(95)00034-5     Document Type: Review

References (73)

1. Rationale and applications for macromolecular Gd-based contrast agents
2. New directions in the development of MR imaging contrast media
3. Highlevel conjugation of chelating agents onto immunoglobulins: use of an intermediary poly(l-lysine)-diethylenetriaminepentaacetic acid carrier
4. Monoclonal antibody modification with chelate-linked high-molecular-weight polymers: major increases in polyvalent cation binding without loss of antigen binding
5. Modification of monoclonal antimyosin antibody: enhanced specificity of localization and scintigraphic visualization in acute experimental myocardial infarction
6. Magnetic resonance imaging of gadolinium-labeled monoclonal antibody polymers directed at human T lymphocytes implanted in canine brain
7. Pharmaceutical iron oxides for MR imaging
8. Status of liposomes as MR contrast agents
9. Nanocrystalline CT contrast agents for blood pool and liver-spleen imaging
10. A comparison between IEEC, a new biodegradable particulate contrast medium, and iohexol in a tumor model of computed tomography imaging of the liver
11. Preparation and water relaxation properties of proteins labeled with paramagnetic metal chelates
12. 111indium
13. Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool imaging: preparation and characterization
14. AUR Memorial Award 1991. Immunogenicity of gadolinium-based contrast agents for magnetic resonance imaging. Induction and characterization of antibodies in animals
15. Development of humoral immune response against a macrocyclic chelating agent (DOTA) in cancer patients receiving radioimmunoconjugates for imaging and therapy
16. 99mTc]-HSA) for cardiac blood pool imaging
17. Cardiac bloodpool scintigraphy using technetium-99m DTPA-HSA: comparison with in vivo technetium-99m RBC labeling
18. Technetium-99m labelled human serum albumin for ventriculography: a comparative evaluation of six labelling kits
19. Technetium-99m mercaptoalbumin as a potential substitute for technetium-99m labelled red blood cells
20. Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies
21. Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool and perfusion imaging
22. Vascular mapping using albumin-(Gd-DTPA), an intravascular MR contrast agent, and projection MR imaging
23. Acute myocardial ischemia and reperfusion: MR imaging with albumin-Gd-DTPA
24. Duration and selectivity of blood-brain barrier breakdown in chronic relapsing experimental allergic encephalomyelitis studied by gadolinium-DTPA and protein markers
25. Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design
26. Paramagnetic agents as tracers in magnetic resonance imaging. Extrapolations from Gd-DTPA to everything
27. 3+ protein-chelate conjugates
28. Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agent: imaging characteristics in normal rat tissues
29. In vivo and in vitro evaluation of Gd-DTPA-poly(l-lysine) as a macromolecular contrast agent for magnetic resonance imaging
30. MR angiography with gadopentetate dimeglumine-poly(l-lysine): evaluation in rabbits
31. Experimental Gd-DTPA poly(l-lysine) enhanced MR angiography: sequence optimization
32. NMR imaging study of the pharmacodynamics of poly(l-lysine)-gadolinium-DTPA in the rabbit and the rat
33. Differentiation of capillary leak and hydrostatic pulmonary edema with a macromolecular MR imaging contrast agent
34. Magnetic resonance imaging detection of an experimental pulmonary perfusion deficit using a macromolecular contrast agent. Poly(l-lysine)-gadolinium-DTPA40
35. Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion
36. Differentiation of alveolitis and pulmonary fibrosis with a macromolecular MR maging contrast agent
37. Gd-DTPA-poly(l-lysine)-enhanced pulmonary time-of-flight MR angiography
38. Detection of zonal renal ischemia with contrast-enhanced MR imaging with a macromolecular blood pool contrast agent
39. Myocardial infarction: assessment with an intravascular MR contrast medium. Work in progress
40. Magnetic resonance imaging demonstration of pharmacologic-induced myocardial vasodilatation using a macromolecular gadolinium contrast agent
41. Gd-DTPA-cas-cade-polymer: potential blood pool contrast agent for MR imaging
42. Effect of varying the molecular weight of the MR contrast agent Gd-DTPA-poly(l-lysine) on blood pharmacokinetics and enhancement patterns
43. Water-soluble polysaccharides as carriers of paramagnetic contrastagents for magnetic resonance imaging: synthesis and relaxation properties
44. Use of paramagnetic chelated metal derivatives of polysaccharides and spin-labeled polysaccharides as contrast agents in magnetic resonance imaging
45. Polymeric contrast agents for magnetic resonance imaging: synthesis and characterization of gadolinium diethylenetriaminepentaacetic acid conjugated to polysaccharides
46. Iodinated polymer as blood-pool contrast agent. Computed tomography evaluation in rabbits
47. In vivo MR evaluation of Gd-DTPA conjugated to dextran in normal rabbits
48. MR imaging of acute myocardial infarction in pigs using Gd-DTPA-labeled dextran
49. Hydroxyethyl starchferrioxamine: a potential MR contrast agent for diagnosis of hepatic metastasis
50. Copolymeric magnetic resonance contrast agents
51. Dynamics of tumor imaging with Gd-DTPA-poly(ethylene glycol) polymers: dependence on molecular weight
52. Crosslinked DTPA polysaccharides for magnetic resonance imaging. Synthesis and relaxation properties
53. Biodistribution and magnetic resonance imaging of cross-linked DTPA polysaccharides
54. Dendrimer-based metal chelates a new class of magnetic resonance imaging agents
55. Radiopharmaceuticals for cardiac imaging: myocardial infarction, perfusion, metabolism, and ventricular function (blood pool)
56. Studies of the hepatobiliary scintiscanning agent Tc-DISIDA
57. Magnetic resonance contrast media: principles and progress
58. Biodistribution and safety studies of MS-264, a new liver agent with high hepatobiliary specificity
59. Evaluation of tumor cellular volume fraction and interstitial albumin concentration using Gd-DTPA and a novel albumin-binding contrast agent
60. A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies
61. Detection of pulmonary emboli using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits
62. The toxicity of high molecular weight poly(ethylene glycol)s: chronic oral and parenteral administration
63. The therapeutic value of poly(ethylene glycol)-modified proteins
64. The conjugation of proteins with polyethylene glycol and other polymers. Altering properties of proteins to enhance their therapeutic potential
65. Alteration of immunological properties of bovine serum albumin by covalent attachment of pol-(ethylene glycol)
66. Pulmonary vascular cine MR imaging: a noninvasive approach to dynamic imaging of the pulmonary circulation
67. Suspected pulmonary embolism: prospective evaluation with pulmonary MR angiography
68. Tumor angiogenesis
69. The role of angiogenesis in tumor growth
70. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
71. Tumor neovascularity imaging by contrast-enhanced MR angiography
72. Synthetic copolymer kit for radionuclide blood-pool imaging