Membrane protein structure: The contribution and potential of novel solid state NMR approaches (review)

Molecular Membrane Biology

Volumn 12, Issue 3, 1995, Pages 233-246

  Watts, Anthony ^a   Ulrich, Anne S ^a   Middleton, David A ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Ligand binding sites; Membrane protein structure; Molecular conformation; Residue structure and dynamics; Solid state NMR

Indexed keywords

MEMBRANE PROTEIN;

CHEMICAL STRUCTURE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; REVIEW;

MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 0029332135     PISSN: 09687688     EISSN: None     Source Type: Journal    
DOI: 10.3109/09687689509072423     Document Type: Review

References (118)

1. Structure of the reaction center from Rhodobacter sphaeroides R-26: the protein subunits
2. The probable arrangement of the helices in G protein-coupled receptors
3. Homologies between sugar transporters from eukaryotes and prokaryotes
4. Multidimensional NMR methods for protein studies
5. Flat-coil probe for NMR spectroscopy of oriented membrane samples
6. Orientations of amphipathic helical peptides in membrane bilayers determined by solid state NMR spectroscopy
7. Structure and orientation of the antibiotic peptide magainin in membranes by solid state NMR
8. Manifestations of lipid-protein interactions in deuterium NMR
9. 13C-enriched chlorophyll-a/water aggregates with 2-D dipolar correlation spectroscopy
10. Multinuclear NMR studies of bacteriorhodopsin
11. Comparison of rotational-echo double-resonance and double-cross-polarization NMR for detection of weak heteronuclear dipolar coupling in solids
12. 13C]glyphosphate bound to enolpyruvylshikimate-3-phosphate synthase
13. Structures of larger proteins in solution: three- and four-dimensional heteronuclear NMR spectroscopy
14. Deuterium solid state NMR studies of methyl group dynamics in bacteriorhodopsin and retinal model compounds: evidence for a 6-S-trans chromophore in the protein
15. Determination of membrane protein structure by rotational resonance NMR: bacteriorhodopsin
16. Anisotropy and NMR of macromoleculares
17. Protein structure by solid state NMR
18. Solid state NMR structural studies of peptides and proteins in membranes
19. 13C MAS NMR evidence for a 15,15′ -cis configuration of the spheroidene in the Rhodobacter sphaeroides photosynthetic reaction center
20. Magic angle spinning NMR of photosynthetic components
21. Carbon-13 and proton NMR studies of the interactions of lipids with membrane proteins
22. Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3 Å resolution
23. Human erythrocyte Band 3: solubilization and reconstitution into two-dimensional crystals
24. 13C-solid state NMR of bacteriorhodopsin: assignment of specific aspartic acids and structural implications of single site mutations
25. NMR FT spectroscopy, Nobel lecture
26. 13C-Lys-bacteriorhodopsin: Schiff base photoisomerization
27. Heteronuclear three-dimensional NMR spectroscopy of isotopically labelled biological macromolecules
28. 13C] tyrosine
29. + and CI - transport
30. Detection of weak heteronuclear dipolar coupling by rotational echo double resonance nuclear magnetic resonance
31. NMR constraints on the location of the retinal chromophore in rhodopsin and bathorhodopsin
32. Localization of the retinal protonated Schiff base counterion in rhodopsin
33. 13C NMR detection of a perturbed 6-s-trans chromophore in bacteriorhodopsin
34. Model for the structure of bacteriorhodopsin based on high-resolution electror. cryo-microscopy
35. Sideband intensities in NMR spectra of samples spinning at the magic angle
36. 3-gramicidin A in multilamellar dimyristoyl-phosphatidylcholine dispersions
37. Deuterium NMR of VAII-Ala3-gramicidin A in oriented DMPC bilayers
38. An investigation of the ligand binding site of the glutamine binding protein of E. coli using REDOR NMR
39. Tryptophans in membrane proteins: indole ring orientations and functional implications in the gramicidin channel
40. Surface dynamics of the integral membrane protein bacteriorhodopsin
41. High-resolution conformation of gramicidin A in a lipid bilayer by solid state NMR
42. Structure and dynamics from solid state NMR spectroscopy
43. Two light-inducing membrane proteins: bacteriorhodopsin and the mammalian rhodopsin
44. 2H-NMR study
45. Dynamics of amino acid side chains in membrane proteins by high field solid state deuterium nuclear magnetic resonance spectroscopy
46. Orientations of the tryptophan 9 and 11 side chains of the gramicidin channel based on deuterium NMR spectroscopy
47. Atomic model of plant light-harvesting complex by electron crystallography
48. 15N] Arginine labeled bacteriorhodopsin
49. 15N NMR investigations of the N intermediate of bacteriorhodopsin
50. Side-chain structure and dynamics at the lipid-protein interface: Val-1 of the gramicidin A channel
51. Lipid-peptide interface: valine conformation and dynamics in the gramicidin channel
52. Theory and simulations of homonuclear spin pair systems in rotating solids
53. Three dimensional structural constraints in the form of orientational constraints from chemical shift anisotropy: the polypeptide backbone of gramicidin A in a lipid bilayer
54. Association of lipids with membrane proteins
55. Determination of a precise interatomic distance in a helical peptide by REDOR NMR
56. Determination of internuclear distances and the orientation of functional groups by solid state NMR: rotational resonance study of the conformation of retinal in bacteriorhodopsin
57. fd coat protein structure in membrane environments
58. Inter-tryptophan distances in rat cellular retinal binding protein II by solid state NMR
59. General and practical aspects of membrane protein crystallisation
60. X-ray cystallographic structure determination of membrane protein from photosynthesis and bioenergetic
61. 13C-NMR study of carbons C-5 and C-12 of the chromophore of bovine rhodopsin
62. Solid-state NMR derived model for dynamics in the polypeptide backbone of the gramicidin A channel
63. 15N-NMR: application to Bombyx mori silk fibroin fibers
64. Solid-state NMR spectroscopy of proteins
65. Solid state NMR structural studies of proteins
66. NMR structural studies of membrane proteins
67. Protein structure determination with three- and four-dimensional NMR spectroscopy
68. The structural basis of the functioning bacteriorhodopsin: an overview
69. Dynamical and temperature dependent effects of lipid-protein interactions. Application of deuterium nuclear magnetic resonance and electron paramagnetic resonance spectroscopy to the same reconstitutions of cytochrome c oxidase
70. Determination of C-N internuclear distances by rotational-echo double-resonance NMR of solids
71. High resolution structure and dynamic implications for a double-helical gramicidin A conformer
72. Polypeptide conformational space. Dynamics by solution NMR. Disorder by X-ray crystallography
73. Rotational resonance NMR measurements of internuclear distances in an α-helical peptide
74. 2 synthase-1
75. Proton enhanced NMR of dilute spins in solids
76. Reversible inhibitors of gastric H/K-ATPase as both potential therapeutic agents and probes of pump function
77. 2H NMR of the gramicidin A backbone in a phospholipids bilayer
78. The structure of an integral membrane peptide: A deuterium NMR study of gramicidin
79. Dynamics of an integral membrane peptide: A deuterium NMR relaxation study of gramicidin
80. Rotational resonance in solid state NMR
81. 13C NMR studies of the effect of sodium ions on the gramicidin A ion channel
82. Functional domains of the gastric H,K- ATPase
83. Structural aspects of the gastric H,K-ATPase
84. Projection structure of rhodopsin
85. Deuterium magnetic resonance: theory and application to lipid membranes
86. 2H-NMR as a method to study structure, dynamics, and interactions
87. NMR and lipid-protein interactions
88. 13C-NMR study of the topography and dynamics of methionine residues in detergent-solubilized bacteriorhodopsin
89. NMR order parameter analysis of a peptide plane aligned in a lyotropic ligand crystal
90. 15N-NMR: Application to Bombyx mori silk fibroin fibers
91. NMR studies of the structure and dynamics of the membrane-bound bacteriophage Pfl coat protein
92. Magic angle spinning NMR methods for internuclear distance measurements
93. Determination of helix-helix interactions in membranes by rotational resonance NMR
94. High resolution solid-state NMR of proteins
95. Solid-state NMR approaches for studying membrane protein structure
96. 13C NMR studies of the retinal chromophore in rhodopsin
97. 13C NMR of the retinal chromophore in photointermediates of bacteriorhodop-sin: characterization of two forms of M
98. Structure and protein environment of the retinal chromophore in light- and dark-adapted bacteriorhodopsin studied by sold-state NMR
99. Solid-state NMR studies of the mechanism of the opsin shift in the visual pigment rhodopsin
100. 13C magic angle spinning NMR studies of bathorhodopsin, the primary photoproduct of rhodopsin
101. Interfacial conformation of dipalmitoylglycerol and dipalmitoylphosphatidylcholine in phospholipid bilayers
102. Structure and orientation of the transmembrane domain of glycophorin A in lipid bilayer
103. Site-directed isotope labelling and FTIR spectroscopy of bacteriorhodopsin
104. + symport protein in native membranes
105. Experimental determination of torsion angles in the polypeptide backbone of the gramicidin A channel by solid state NMR
106. Rotational resonance NMR study of the active site structure in bacteriorhodopsin: conformation of the Schiff base linkage
107. 2H-NMR lineshapes of immobilized uniaxially oriented membrane proteins
108. Structure determination of the cyclohexene-ring of retinal in bacteriorhodopsin by solid-state deuterium-NMR
109. 2H-NMR
110. Reorientation of retinal in the M-photointermediate of bacteriorhodopsin
111. Two-dimensional structure of the membrane domain of human band 3, the anion transport protein of the erythrocyte membrane
112. NMR methods to characterize lipid protein interactions at membrane surfaces
113. Porin conformation in the absence of calcium — refined structure at 2 Å resolution
114. Protein structure determination in solution by NMR spectroscopy
115. NMR studies of retinal proteins