Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

BioEssays

Volumn 17, Issue 6, 1995, Pages 471-480

  Nigg, Erich A ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASES; DNA;

AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CYCLE; COMPARATIVE STUDY; DNA REPLICATION; GENE EXPRESSION REGULATION; HOMEOSTASIS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; VERTEBRATE;

AMINO ACID SEQUENCE; ANIMAL; CELL CYCLE; COMPARATIVE STUDY; CYCLIN-DEPENDENT KINASES; DNA; DNA REPLICATION; GENE EXPRESSION REGULATION; HOMEOSTASIS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; VERTEBRATES;

EID: 0029317904     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.950170603     Document Type: Review

References (95)

1. Signals and genes in the control of cell‐cycle progression
2. Tumor suppressor genes
3. Creative blocks: cell cycle checkpoints and feedback controls
4. Checkpoints: controls that ensure the order of cell cycle events
5. Animal cell cycles and their control
6. 1 to S‐phase transition
7. Cyclins and cyclin‐dependent kinases: take your partners
8. Control of the yeast cell cycle by the Cdc28 protein kinase
9. 1 phase progression: cycling on cue
10. 1 cyclins
11. Mitosis in transition
12. 2/M and metaphase/anaphase transitions
13. Cdc2 regulatory factors
14. cdc2 and its companion cyclin‐dependent kinases
15. Cyclins and their partners: from a simple idea to complicated reality
16. Cyclins and cancer II: cyclin D and CDK inhibitors come of age
17. Cell cycle regulation in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe
18. Cell cycle regulation in higher plants
19. 1 cyclins
20. 1 cyclins in the next cycle
21. cdc2‐mitotic B cyclin complex
22. Cyclin E controls S phase progression and its down‐regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
23. Ordering S phase and M phase in the cell cycle
24. Characterization of the in vitro reconstituted cyclin A or B1‐dependent cdk2 and cdc2 kinase activities
25. A‐ and B‐type cyclins differentially modulate substrate specificity of cyclin‐cdk complexes
26. Nuclear localization of vertebrate cyclin A correlates with its ability to form complexes with cdk catalytic subunits
27. The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B
28. 1 in mammalian fibroblasts
29. Cyclin A is required at the onset of DNA replication in mammalian fibroblasts
30. Cyclin A is required at two points in the human cell cycle
31. 2‐M transition
32. A brain‐specific activator of cyclin‐dependent kinase 5
33. p35 is a neural‐specific regulatory subunit of cyclin‐dependent kinase 5
34. Phosphorylation of the transcription factor PH04 by a cyclin‐CDK complex, PHO80‐PHO85
35. Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation
36. Activation of the various cyclin/cdc2 protein kinases
37. Protein kinase regulation: insights from crystal structure analysis
38. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin‐dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
39. cdc2
40. MO15
41. MO15, a cdc‐2‐related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes
42. A novel cyclin associates with MO15/CDK7 to form the CDK‐activating kinase
43. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK‐activating kinase) J
44. A cyclin associated with the CDK‐activating kinase MO15
45. The Kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae
46. Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity
47. The MO15 cell cycle kinase is associated with the TFIIH transcription‐DNA repair factor
48. Relationship of CDK‐activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
49. Phosphorylation of RNA polymerase by the murine homologue of the cell‐cycle control protein cdc2
50. MO15
51. MO15, the catalytic subunit of cdk‐activating kinase, during Xenopus oogenesis and embryogenesis
52. MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk‐activating kinase activity in Xenopus oocytes
53. Joining the complex: cyclin‐dependent kinase inhibitory proteins and the cell cycle
54. Cdk inhibitors: on the threshold of checkpoints and development
55. Direct inhibition of the yeast cyclin‐dependent kinase Cdc28‐Cln by Far1
56. cdc28 protein kinase activity from Saccharomyces cerevisiae
57. 1 to S transition in S cerevisiae
58. 1 transition in Saccharomyces cerevisiae
59. 1 phase of the cell cycle by the rum1+ gene
60. 1 cyclin‐dependent kinases
61. p21 is a universal inhibitor of cyclin kinases
62. p21‐containing cyclin kinases exist in both active and inactive states
63. WAF1, a potential mediator of p53 tumor suppression
64. Differential effects by the p21 CDK inhibitor on PCNA‐dependent DNA replication and repair
65. 1 cycliri‐Cdk protein kinase activity, is related to p21
66. Kip1, a cyclin‐dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
67. A new regulatory motif in cell‐cycle control causing specific inhibition of cyclin D/CDK4
68. INK4B is a potential effector of TGF‐b‐induced cell cycle arrest
69. A cell cycle regulator potentially involved in genesis of many tumor types
70. The PCL2 (ORFD)‐PHO85 cyclin‐dependent kinase complex: a cell cycle regulator in yeast
71. Negative regulation of the growth‐promoting transcription factor E2F‐1 by a stably bound cyclin A‐dependent protein kinase
72. Phosphorylation of E2F‐1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein
73. Mitotic spindle morphogenesis in animal cells
74. Mitotic regulation of microtubule cross‐linking activity of CENP‐E kinetochore protein
75. Anaphase is initiated by proteolysis rather than by the inactivation of maturation‐promoting factor
76. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast
77. Distinct molecular mechanisms regulate cell cycle timing at successive stages of Drosophila embryogenesis
78. Distinct roles for cyclin‐dependent kinases in cell cycle control
79. Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85
80. Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A‐ and B‐type cyclins
81. Phosphate‐regulated inactivation of the kinase PHO80‐PHO85 by the CDK inhibitor PHO81
82. cdc2 and CDK2 protein kinases
83. Regulation of eukaryotic DNA replication
84. Rules to replicate by
85. Intermediate filaments: not so tough after all
86. Cytokinesis
87. Mitosis‐specific phosphorylation of the nuclear oncoproteins Myc and Myb
88. Elongation factor EF‐1 delta, a new target for maturation‐promoting factor in Xenopus oocytes
89. Multi‐site phosphorylation of the protein tyrosine phosphatase PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation
90. Phosphorylation of RAP1GAP during the cell cycle
91. Mitosis‐specific phosphorylation of polyomavirus middle sized tumor antigen and its role during cell transformation
92. Multiple phosphorylation of stathmin
93. Cell‐cycle‐regulated phosphorylation of oncoprotein 18 on Ser16, Ser25, and Ser38