Lymphopoiesis: Transcription factors controlling B-cell development

Current Biology

Volumn 5, Issue 6, 1995, Pages 605-608

  Desiderio, Stephen ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA BINDING PROTEINS; HELIX LOOP HELIX PROTEIN; HELIX LOOP HELIX PROTEIN E12; HELIX LOOP HELIX PROTEIN E47; HELIX-LOOP-HELIX PROTEIN E12; HELIX-LOOP-HELIX PROTEIN E47; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NF HB PROTEIN; NF-HB PROTEIN; NUCLEAR PROTEIN; TRANS ACTIVATORS; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR ITF 2; TRANSCRIPTION FACTOR ITF-2;

ANIMAL; B LYMPHOCYTE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIESIS; IMMUNE DEFICIENCY; MOUSE; MOUSE MUTANT; MULTIGENE FAMILY; PHYSIOLOGY; REVIEW; TRANSGENIC MOUSE;

ANIMAL; B-LYMPHOCYTES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HELIX-LOOP-HELIX MOTIFS; HEMATOPOIESIS; IMMUNOLOGIC DEFICIENCY SYNDROMES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MULTIGENE FAMILY; NF-KAPPA B; NUCLEAR PROTEINS; TRANS-ACTIVATORS;

EID: 0029317362     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(95)00121-7     Document Type: Article

References (20)

1. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
2. The helix-loop-helix gene E2A is required for B cell formation
3. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
4. Targeted disruption of the p50 subunit of NF-kappa-B leads to multifocal defects in immune responses
5. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD and myc proteins
6. Modulation of the IgH enhancer's cell type specificity through a genetic switch
7. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T cell line
8. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins
9. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo.
10. Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis and neurogenesis
11. IL-2 receptor alpha chain (CD25,Tac) expression defines a crucial stage in pre-B cell development
12. RAG-1-deficient mice have no mature B and T lymphocytes
13. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
14. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
15. The protein Id: a negative regulator of helix-loop-helix DNA binding protein
16. Constitutive expression of the Id1 gene impairs mouse B cell development
17. Expression of relB is required for the development of thymic medulla and dendritic cells
18. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of relB, a member of the NF-kappa-B/Rel family
19. Requirement of transcription factor PU1 in the development of multiple haematopoietic lineages
20. The Ikaros gene is required for the development of all lymphoid lineages