Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila

Current Biology

Volumn 5, Issue 6, 1995, Pages 643-650

  Fietz, M J ^a   Jacinto, A ^b   Taylor, A M ^b   Alexandre, C ^b   Ingham, P W ^b  

^a UNIVERSITY OF TASMANIA   (Australia)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DPP PROTEIN, DROSOPHILA; HEDGEHOG PROTEIN, DROSOPHILA; INSECT HORMONE; PEPTIDE FRAGMENT; PROTEIN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMISTRY; DROSOPHILA MELANOGASTER; EMBRYOLOGY; FORELIMB; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LARVA; METABOLISM; MOLECULAR GENETICS; MORPHOGENESIS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; DROSOPHILA MELANOGASTER; GENE EXPRESSION REGULATION; INSECT HORMONES; LARVA; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; PEPTIDE FRAGMENTS; PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC; WING;

EID: 0029311316     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(95)00129-1     Document Type: Article

References (23)

1. Requirements for hedgehog, a segment polarity gene, in patterning larval and adult cuticle of Drosophila.
2. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
3. Cell-interaction between compartments establishes the proximal–distal axis of Drosophila legs
4. Targetted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings
5. Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
6. Hedgehog is a signalling protein with a key role in patterning Drosophila imaginal discs
7. Drosophila hedgehog acts as a morphogen in cellular patterning
8. Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched.
9. Interactions between segment polarity genes and the generation of the segmental pattern in Drosophila.
10. Role of the Drosophila patched gene in positional signalling
11. Regulation of wingless transcription in the Drosophila embryo
12. Secretion and localized transcription suggests a role in positional signalling for products of the segmentation gene hedgehog.
13. Auto-proteolysis in hedgehog protein biogenesis
14. Contrasting distributions of patched and hedgehog proteins in the Drosophila
15. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
16. The Serrate locus of Drosophila and its role in morphogenesis of imaginal discs: control of cell proliferation
17. Localised hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryo
18. Products, genetic-linkage and limb patterning activity of a murine hedgehog gene
19. Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
20. Patterning of mammalian somites by the surface ectoderm and the notochord: evidence for sclerotome induction by Sonic hedgehog/Vhh-1.
21. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
22. Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell–cell communication