Early endonuclease activation following reversible focal ischemia in the rat brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 15, Issue 3, 1995, Pages 385-388

  Charriaut Marlangue, C ^a   Margaill, I ^b   Plotkine, M ^b   Ben Ari, Y ^a  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Apoptosis; Calcium; Necrosis; Pulsed field electrophoresis

Indexed keywords

DNA; ENDONUCLEASE; CALCIUM; DNA FRAGMENT;

ANIMAL; ARTICLE; BRAIN ISCHEMIA; ENZYMOLOGY; GENETICS; MALE; METABOLISM; RAT; RAT STRAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; BRAIN INJURY; CELL DEATH; CHROMATIN; CONTROLLED STUDY; DNA DEGRADATION; DNA STRAND BREAKAGE; ENZYME ACTIVATION; NECROSIS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

ANIMAL; BRAIN ISCHEMIA; DNA; ENDONUCLEASES; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029299309     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.1995.48     Document Type: Article

References (17)

1. Arends M, Morris R, Wyllie A (1990) Apoptosis: the role of the endonuclease. Am J Pathol 136:593-608
2. Goto K, Ishige A, Sekiguchi K, Lizuka S, Sugimoto A, Yuzurihara M, Aburada M, Hosoya E. Kogure K (1990) Effects of cycloheximide on delayed neuronal death in rat hippocampus. Brain Res 534:299-302
3. Héron A, Pollard H, Dessi F, Moreau J, Lasbennes F, Ben-Ari Y, Charriaut-Marlangue C (1993) Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain. J Neurochem 61:1973-1976
4. Linnik M, Zobrist R, Marsa D, Hatfield M (1993) Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24:2002-2009
5. Lognonne J (1993) Introduction to pulsed-field gel electrophoresis. Methods Mol Cell Biol 4:49-55
6. MacManus J, Buchan A, Hill I, Rasquinha I, Preston E (1993) Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neurosci Lett 164:89-92
7. MacManus J, Hill I, Huang Z, Rasquinha I, Xue D, Buchan A (1994) DNA damage consistent with apoptosis in transient focal ischaemic neocortex. Neuroreport 5:493-496
8. Papas S, Crepel V, Hasboun D, Jorquera I, Chinestra P, Ben-Ari Y (1992) Cycloheximide reduces the effects of anoxic insult in vivo and in vitro. Eur J Neurosci 4:758-765
9. Pollard H, Cantagrel S, Charriaut-Marlangue C, Moreau J, Ben-Ari Y (1994a) Apoptosis associated DNA fragmentation in epileptic brain damage. Neuroreport 5:1053-1055
10. Pollard H, Charriaut-Marlangue C, Cantagrel S, Represa A, Robain O, Moreau J, Ben-Ari Y (1994b) Kainate-induced apoptotic cell death in hippocampal neurons. Neuroscience 63:7-18
11. Pulsinelli W, Brierley J, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11:491-498
12. Roy C, Brown D, Little J, Valentine B, Walker P, Sikorska M, LeBlanc J, Chaly N (1992) The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes. Exp Cell Res 200:416-424
13. Shigeno T, Yamasaki Y, Kato G, Kusaka K, Mima T, Takakura K, Graham D, Furukawa S (1990) Reduction of delayed neuronal death by inhibition of protein synthesis. Neurosci Lett 120:117-119
14. Tominaga T, Kure S, Narisawa K, Yoshimoto T (1993) Endonuclease activation following focal ischemic injury in the rat brain. Brain Res 608:21-26
15. Walker P, Kokileva L, LeBlanc J, Sikorska M (1993) Detection of initial stages of DNA fragmentation in apoptosis. Biotechniques 15:1032-1040
16. Wyllie A (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous nuclease activation. Nature 284:555-556
17. Wyllie A, Morris R, Smith A, Dunlop D (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 142:67-75