Control of signal transduction and morphogenesis by Ras

Seminars in Cell Biology

Volumn 6, Issue 2, 1995, Pages 89-94

  Hughes, David A ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

cell polarity; fission yeast; MAP kinase; mating; Ras

Indexed keywords

FUNGAL PROTEIN; GTP BINDING PROTEINS; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; MATING FACTOR (SCHIZOSACCHAROMYCES); PEPTIDE; PHEROMONE; PROTEIN KINASE; RAS PROTEINS, FUNGAL;

AMINO ACID SEQUENCE; COMPARATIVE STUDY; EUKARYOTIC CELL; FUNGAL GENE; GENETICS; MOLECULAR GENETICS; MORPHOGENESIS; ONCOGENE RAS; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; REVIEW; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; COMPARATIVE STUDY; EUKARYOTIC CELLS; FUNGAL PROTEINS; GENES, FUNGAL; GENES, RAS; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; PEPTIDES; PHEROMONES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY;

SCHIZOSACCHAROMYCES POMBE;

EID: 0029286303     PISSN: 10434682     EISSN: None     Source Type: Journal    
DOI: 10.1016/1043-4682(95)90005-5     Document Type: Article

References (49)

1. The GTPase superfamily: a conserved switch for diverse cell functions
2. RAS genes in the budding yeast Saccharomyces cerevisiae, in Signal Transduction
3. Molecular cloning and sequence analysis of a ras gene from Schizosaccharomyces pombe
4. The cloning and characterization of a RAS gene from Schizosaccharomyces pombe
5. All ras proteins are polyisoprenylated but only some are palmitoylated
6. Role of a ras homolog in the life cycle of Schizosaccharomyces pombe
7. Involvement of ras in sexual differentiation but not in growth control in fission yeast
8. Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe
9. sar1, a gene from Schizosaccharomyces pombe encoding a GAP-like protein that regulates ras1
10. Homologous activators of ras in fission and budding yeast
11. Transcriptional regulation of a Ras nucleotide-exchange factor gene by extracellular signals in fission yeast
12. Sex appeal in fission yeast
13. Mating pheromone-like diffusible factor released by Schizosaccharomyces pombe
14. 1 arrest in the mating partner
15. 1 arrest in the fission yeast Schizosaccharomyces pombe
16. The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription
17. Isolation of the gene encoding G protein α-subunit from Schizosaccharomyces pombe
18. The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has significant homology with the Saccharomyces cerevisiae Ste2 protein
19. Schizosaccharomyces pombe map3 encodes the putative M-factor receptor
20. The pathway to signal achievement
21. Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases
22. Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase
23. Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms
24. A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast
25. byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial phenotypic suppression of ras1 mutant phenotype
26. Functional conservation between Schizosaccharomyces pombe ste8 and Saccharomyces cerevisiae STE11 protein kinases in yeast signal transduction
27. Complex formation between RAS and RAF and other protein kinases
28. Cooperative interaction of S. pombe proteins required for mating and morphogenesis
29. A novel genetic system to detect protein-protein interactions
30. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
31. Activation of Raf as a result of recruitment to the plasma membrane
32. The pheromone response pathway in Saccharomyces cerevisiae
33. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein βγ subunits to downstream signaling components
34. A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae
35. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
36. Complexes between STE5 and components of the pheromone-responsive MAP kinase module
37. + encodes a transcription factor with an HMG motif that is a critical regulator of sexual development
38. Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements
39. Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to ras1
40. Characterization of the Schizosaccharomyces pombe ral2 gene implicated in the activation of the ras1 gene product
41. Control of the yeast budsite assembly GTPase Cdc42: catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3
42. Proteins regulating Ras and its relatives
43. A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains
44. A homologue of the ras-related CDC42 gene from Schizosaccharomyces pombe
45. Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe
46. Development of cell polarity in budding yeast
47. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors
48. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
49. Localization of F-actin through the cell division cycle of Schizosaccharomyces pombe