Reduced Inhibitory Capacity in Prefrontal Cortex of Schizophrenics

Archives of General Psychiatry

Volumn 52, Issue 4, 1995, Pages 267-268

  Lee, Dennis E ^a   Tobin, Allan J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; DOPAMINE;

HUMAN; NERVE CELL; NERVE CELL INHIBITION; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY; PREFRONTAL CORTEX; SCHIZOPHRENIA;

DOPAMINE; GAMMA-AMINOBUTYRIC ACID; HUMANS; NEURAL INHIBITION; NEURONS; PREFRONTAL CORTEX; SCHIZOPHRENIA;

EID: 0029278951     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.1995.03950160017003     Document Type: Letter

References (15)

1. Benes FM, McSparren J, Bird ED, SanGiovanni JP, Vincent SL. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry. 1991;48: 996–1001.
2. Scheibel AB, Kovelman JA. Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient. Biol Psychiatry. 1981;16: 101–102.
3. Buchsbaum MS, DeLisi LE, Holcomb HH, et al. Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch Gen Psychiatry. 1984;41: 1159–1166.
4. Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia, I. Arch Gen Psychiatry. 1986;43: 114–124.
5. Akbarian S, Kim JJ, Potkin SG, et al. Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry. 1995;52: 258–266.
6. Erlander MO, Tobin M. The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem Res. 1991;16: 215–226.
7. Erlander MO, Tillakaratne NJK, Feldblum S, Patel N, Tobin M. Two genes encode distinct glutamate decarboxylases. Neuron. 1991;7: 91–100.
8. Benes FM, Vincent SL, Alsterberg O, Bird ED, SanGiovanni JP. Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics. J Neurosci. 1992;12: 924–929.
9. Hanada S, Mita T, Nishinio N, Tanaka C. [3H]Muscimol binding sites increased in autopsied brains of chronic schizophrenics. Life Sci. 1986;40: 259–266.
10. Fuster J. The Preftontal Cortex. New York, NY: Raven Press; 1980.
11. Simpson MDC, Slater P, Royston MC, Deakin JFW. Regionally selective deficits in uptake sites for glutamate and gamma-aminobutyric acid in the basal ganglia of schizophrenics. Psychiatry Res. 1992;42: 273–282.
12. Simpson MDC, Slater P, Deakin JFW, Roysteon MC, Skan WJ. Reduced GABA uptake sites in the temporal lobe in schizophrenia. Neurosci Lett. 1989;107: 211–215.
13. Bannon MJ, Roth RH. Pharmacology of mesocortical dopamine neurons. Pharmacol Rev. 1983;35: 53–68.
14. Thaker GK, Tamminga CA, Alphs LD, Lafferman J, Ferraro TN, Hare TA. Brain γ-aminobutyric acid abnormality in tardive dyskinesia: reduction in cerebrospinal fluid GABA levels and therapeutic response to GABA agonist treatment. Arch Gen Psychiatry. 1987;44: 522–529.
15. Crow TJ, Cross AJ, Cooper SJ, et al. Neuotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementias and depression, and suicides. Neuropharmacology. 1984;23: 1561–1569.