Structure‐function relationships in Src family and related protein tyrosine kinases

BioEssays

Volumn 17, Issue 4, 1995, Pages 321-330

  Superti‐Furga, Giulio ^a   Courtneidge, Sara A ^a,b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b SUGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; PROTO ONCOGENE PROTEIN PP60(C SRC);

ANIMAL; BINDING SITE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMAL; BASE SEQUENCE; BINDING SITES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN-TYROSINE KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029278886     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.950170408     Document Type: Review

References (80)

1. Non‐receptor protein tyrosine kinases
2. Nonreceptor tyrosine protein kinases
3. Ras1‐dependent signalling by ectopically expressed Drosophila src gene product in the embryo and developing eye
4. SH2 and SH3 domains
5. Signalling through SH2 and SH3 domains
6. BCR sequences essential for transformation by the BCR‐ABL oncogene bind to the ABL SH2 regulatory domain in a non‐phosphotyrosine‐dependent manner
7. Molecular ‘Velcro’
8. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide‐free forms
9. lck
10. lck
11. Structural basis for the binding of proline‐rich peptides to the SH3 domain
12. High‐resolution crystal structures of tyrosine kinase SH3 domains complexed with proline‐rich peptides
13. SH2 domains recognize specific phosphopeptide sequences
14. The regulation of Src activity
15. src‐related protein tyrosine kinases and their surface receptors
16. Myristylation and palmitylation of Src family members: the fats of the matter
17. Signal transduction by lymphocyte antigen receptors
18. The cell cycle and c‐Src
19. Identification of Src, Fyn and Lyn SH3‐b nding proteins: implications for a function of SH3 domains
20. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
21. A tail of two src's: mutatis mutandis
22. CSK: a protein‐tyrosine kinase involved in regulation of src family kinases
23. ick at Tyr‐505 and down regulates its catalytic activity
24. Csk inhibition of Src activity requires both the SH2 and SH3 domains of Src
25. Molecular cloning and expression of chicken C‐terminal Src kinase: Lack of stable association with c‐Src protein
26. Deletion of the SH3 domain of SRC interferes with regulation by the phosphorylated carboxy terminal tyrosine
27. Suppression of c‐Src activity by C‐terminal Src kinase involves the c‐Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae
28. csk
29. Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK
30. Ctk: A protein‐tyrosine kinase related to Csk that defines an enzyme family
31. Ntk: a Csk‐related protein‐tyrosine kinase expressed in brain and T lymphocytes
32. The when and how of Src regulation
33. Effects of SH2 and SH3 deletions on the functional activities of wild‐type and transforming variants of c‐ src
34. Association between the PDGF receptor and members of the src family of tyrosine kinases
35. Linker insertion‐deletion mutagenesis of the v‐src gene: isolation of host‐and temperature dependent mutants
36. Aberrant protein phosphorylation at tyrosine is responsible for the growth‐inhibitory action of pp60 v‐src expressed in the yeast Saccharomyces cerevisiae
37. Structure and expression of Spk‐1, a src‐related gene product found in the planarian Dugesia (G) tigrina
38. Multiple src‐related kinase genes,srk1–4, in the fresh water sponge Spongilla lacustris
39. Phosphorylation and regulatory effects of the carboxy terminus of a Drosophila src homolog
40. Overexpressed Drosophila 64B is phosphorylated at its carboxy‐terminal tyrosine, but is not catalytically repressed, in cultured Drosophila cells
41. Cloning of FRK, a novel human intracellular SRC‐like tyrosine kinase‐encoding gene
42. c−src and regulates its activity in neonatal rat brain
43. c−src
44. Constitutive activation of Src family kinases in mouse embryos that lack Csk
45. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
46. Two putative protein‐tyrosine kinases identified by application of the polymerase chain reaction
47. Identification and characterization of a novel tyrosine kinase from megakaryocytes
48. Molecular cloning of a novel non‐receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine‐lacking kinase)
49. Molecular cloning of Isk, a carboxyl‐terminal src kinase (csk) related gene, expressed in leukocytes
50. Three protein kinase structures define a common motif
51. cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation
52. Identification of the regulatory phosphorylation sites in pp42/mitogen‐activated protein kinase (MAP kinase)
53. Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1
54. c−src and a novel protein tyrosine kinase
55. Analysis of the binding of the Src homology 2 domain of Csk to tyrosine‐phosphorylated proteins in the suppression and mitotic activation of c‐Src
56. Csk suppression of Src involves movement of Csk to sites of Src activity
57. The gene involved in X‐linked agammaglobulinaemia is a member of the srs family of protein‐tyrosine kinases
58. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X‐linked agammaglobulinemia
59. A novel protein‐tyrosine kinase,tec, is preferentially expressed in liver
60. Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit
61. Itk, a T‐cell inducible specific tyrosine kinase gene inducible by interleukin‐2
62. Developmental regulation of a murine T‐cell‐specific tyrosine kinase gene, Tsk
63. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
64. Abl tyrosine kinase in signal transduction and cell‐cycle regulation
65. Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP‐rho
66. Abl protein‐tyrosine kinase selects the Crk adapter as a substrate using SH3‐binding sites
67. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c‐abl proto‐oncogene
68. m1 mutation show poor viability and depletion of selected B and T cell populations
69. The Drosophila Abelson proto‐oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development
70. The nuclear tyrosine kinase c‐Abl negatively regulates cell growth
71. Mutation of a phenylalanine conserved in SH3‐containing tyrosine kinases activates the transforming ability of c‐Abl
72. SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence
73. Differential complementation of Bcr‐Abl point mutants with c‐Myc
74. A c‐terminal protein‐binding domain in the retinoblastoma protein regulates nuclear c‐abl tyrosine kinase in the cell‐cycle
75. Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the abl tyrosine kinase
76. Oncogenic activation of c‐Abl by mutation within its last exon
77. Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo