PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

Current Biology

Volumn 5, Issue 4, 1995, Pages 393-403

  Hawkins, Phillip T ^a   Eguinoa, Alicia ^a   Qiu, Rong Guo ^b   Stokoe, David ^b   Cooke, Frank T ^a   Walters, Rhodri ^a   Wennström, Stefan ^c   Claesson Welsh, Lena ^c   Evans, Tony ^b   Symons, Marc ^b   Stephens, Len ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b ONYX PHARMACEUTICALS   (United States)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GTP BINDING PROTEINS; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PLATELET DERIVED GROWTH FACTOR; RAC GTP BINDING PROTEINS; RAC PROTEIN;

ARTICLE; CELL LINE; CELL MEMBRANE PERMEABILITY; ENZYME ACTIVATION; HUMAN; METABOLISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL LINE; CELL MEMBRANE PERMEABILITY; ENZYME ACTIVATION; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMAN; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLATELET-DERIVED GROWTH FACTOR; RAC GTP-BINDING PROTEINS; SUPPORT, NON-U.S. GOV'T;

EID: 0029278739     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(95)00080-7     Document Type: Article

References (58)

1. Oncogenes and signal transduction
2. 3, a new intracellular signalling system?
3. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
4. Pathway of phosphatidylinositol (3,4,5)-trisphosphate synthesis in activated neutrophils
5. An inositol tetrakisphosphate-containing phospholipid in activated neutrophils
6. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
7. Involvement of phosphoinositide 3-kinase in insulin or IGF-1 induced membrane ruffling
8. Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3 kinase
9. Phospatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis and glucose transporter translocation
10. 1-phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells
11. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
12. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
13. Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase
14. PDGF and insulin-dependent pp70 S6K activation mediated by phosphatidylinositol-3-OH kinase
15. c-src complexes and P13-kinase
16. cDNA cloning of a novel 85kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor
17. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
18. Phosphatidylinositol 3-kinase: structure and expression of the 110kd catalytic subunit
19. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signalling pathways
20. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.
21. Phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation
22. Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85 kd subunit
23. Inhibition of histamine secretion by wortmannin through the blockage of phosphatidylinositol 3-kinase in RBL-2H3 cells
24. Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine-nucleotide-binding protein coupled receptor signalling in neutrophil leukocytes
25. The small GTP-binding protein Rac regulates growth factor induced membrane ruffling
26. Bcr encodes a GTPase activating protein for p21 Rac
27. ras upon T cell activation
28. Complexes of polyoma virus middle T antigen and cellular proteins
29. Rac from its inhibitory GDP/GTP exchange protein (rho GDI) followed by its translocation to the plasma membrane
30. Translocation of Rac correlates with NADPH oxidase activation: evidence for equimolar translocation of oxidase components
31. Proteins regulating ras and its relatives
32. ras in fibroblasts
33. Signal transduction through small GTPase — a tale of two GAPS
34. Rac is specifically expressed during the acrosomal assembly stage in rat testis
35. rho family GTPase activating proteins p190 bcr and rhoGAP show distinct specificities in vitro and in vivo
36. Regulation of binding of rhoB p20 to membranes by its specific regulatory protein GDP dissociation inhibitor
37. A novel role of RhoGDI as an inhibitor of GAP proteins
38. A GDP-dissociation inhibitor that serves as a GTPase inhibitor for the ras-like protein CDC42Hs
39. Dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein
40. The identification and characterisation of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein
41. Modulation of guanine nucleotides bound to ras in NIH3T3 cells by oncogenes, growth factors and the GTPase activating protein (GAP)
42. Platelet-derived growth factor increases turnover of GTP/GDP on ras in permeabilized fibroblasts
43. ras GTP complex in swiss mouse 3T3 cells
44. Platelet derived growth factor receptor mediates activation of ras through different signalling pathways in different cell types
45. Requirement for ras protooncogene function during serum-stimulated growth of NIH 3T3 cells
46. ras in activation of extracellular signal regulated kinase 2
47. Tyr-716 in the PDGF β-receptor kinase insert is involved in GRB2 binding and ras activation
48. Activation of phosphoinositide 3-kinase activity by CDC42Hs binding to p85
49. Activation of platelet phosphoinositide 3-kinase requires the small GTP-binding protein rho
50. A brain serine/threonine protein kinase activated by CDC42 and Rac1
51. The biochemical basis of NADPH oxidase of phagocytes
52. Activation Raf as a result of recruitment to the plasma membrane
53. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
54. Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP dissociation
55. Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins
56. RabGDI presents functional Rab9 to the intracellular transport machinery and contributes selectivity to Rab9 membrane recruitment
57. The 2.2å crystal structure of transducin-α complexed with GTPγS
58. A turn-on and a surprise