Degradation of polydispersed poly(l-lactic acid) to modulate lactic acid release

Biomaterials

Volumn 16, Issue 6, 1995, Pages 441-447

  von Recum, Horst A ^c   Cleek, Robert L ^a   Eskin, Suzanne G ^b   Mikos, Antonios G ^c  

^a Department of Chemical Engineering Institute of Biosciences and Bioengineering Cox Laboratory for Biomedical Engineering ^*  (United States)

^b TEXAS BIOTECHNOLOGY CORPORATION   (United States)

^c NONE

Author keywords

biodegradable polymers; lactic acid; modulated release; Poly(l lactic acid); polydispersed polymers

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; COMPOSITION EFFECTS; CONTROLLED DRUG DELIVERY; HYDROLYSIS; MOLECULAR WEIGHT; POLYMER BLENDS;

MODULATED RELEASE; POLYDISPERSED POLYMERS; POLYLACTIC ACIDS;

ORGANIC ACIDS;

BUFFER; LACTIC ACID; PHOSPHATE; POLYLACTIC ACID;

ARTICLE; BIOCOMPATIBILITY; DEGRADATION; DISSOLUTION; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; TEMPERATURE; TIME;

CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, GEL; DELAYED-ACTION PREPARATIONS; FEASIBILITY STUDIES; HYDROGEN-ION CONCENTRATION; LACTATES; LACTIC ACID; MOLECULAR WEIGHT; POLYMERS; PROSTHESES AND IMPLANTS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; TEMPERATURE;

EID: 0029278188     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/0142-9612(95)98816-W     Document Type: Article

References (18)

1. Physico-mechanical properties of degradable polymers used in medical applications: a comparative study
2. Polymers for absorbable surgical sutures
3. Polymers for biodegradable medical devices. 1. The potential of polyesters as controlled macromolecular release systems
4. Resorbable materials of poly(l-lactide). VI. Plates and screws for internal fracture fixation
5. The use of polylactic acid matrix and periosteal grafts for the reconstruction of rabbit knee articular defects
6. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers
7. Prevascularization of porous biodegradable polymers
8. Transplantation of enterocytes utilizing polymercell constructs to produce a neointestine
9. Hepatocyte culture on biodegradable polymeric substrates
10. Poly(l-lactide): a long-term degradation study in vivo
11. Biodegradable polymers for use in surgery — poly(glycolic)/poly(lactic acid) homo and copolymers: 2. In vitro degradation
12. Polylactide. II. Viscosity-molecular weight relationships and unperturbed chain dimensions
13. Thermal characterization of polylactides
14. The effect of the addition of low molecular weight poly(dl-lactide) on drug release from biodegradable poly(dl-lactide) drug delivery systems
15. The biodegradability of polyester blends
16. In vivo degradation of massive poly(α-hydroxy acids): validation of in vitro findings
17. Biological response of intramedullary bone to poly-l-lactic acid