Ribonucleosides in Human Milk. Concentration Profiles of These Minor Constituents as a Functio of the Nursing Time

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 50, Issue 1-2, 1995, Pages 105-113

  Schlimme, Eckhard ^a   Schneehagen, Kirsten ^a  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

Author keywords

Human Milk; Nursing Time; Ribonucleosides; RNA Catabolites

Indexed keywords

RIBONUCLEOSIDE;

ANIMAL; ARTICLE; BREAST MILK; CATTLE; CHEMISTRY; COLOSTRUM; COMPARATIVE STUDY; FEMALE; GOAT; HUMAN; LACTATION; LONGITUDINAL STUDY; MAMMAL; METABOLISM; MILK; PHYSIOLOGY; PREGNANCY; SPECIES DIFFERENCE; TIME;

ANIMAL; CATTLE; COLOSTRUM; COMPARATIVE STUDY; FEMALE; GOATS; HUMAN; LACTATION; LONGITUDINAL STUDIES; MAMMALS; MILK; MILK, HUMAN; PREGNANCY; RIBONUCLEOSIDES; SPECIES SPECIFICITY; TIME FACTORS;

EID: 0029201464     PISSN: 09395075     EISSN: 18657125     Source Type: Journal    
DOI: 10.1515/znc-1995-1-216     Document Type: Article

References (38)

1. Boos K. S. Wilmers B., Sauerbrey R. and Schlimme E. (1988), On-line sample processing and analysis of diol compounds in biological fluids. J. Chromatogr. 456, 93–104.
2. Brookes P. and Lawley P. D. (1960), Methylation of adenosine and adenylic acid. J. Chem. Soc., 539–545.
3. Chheda G. B. (1975), Purine, pyrimidine, pyridine, and imidazole derivatives excreted in human urine. In: Handbook of Biochemistry and Molecular Biology: Nucleic Acids (G. Fasman, ed.). CRC Press, Boca Raton, pp. 215–270.
4. Chheda G. B. and Hong C. I. (1971), Synthesis of naturally occurring 6-ureidopurines and their nucleosides. J. Med. Chem. 14, 748–753.
5. Davis G. E., Suits R. D., Kuo K. C., Gehrke C. W., Waalkes T. P. and Borek E. (1977), High-performance liquid chromatographic separation and quantitation of nucleosides in urine and some other biological fluids. Clin. Chem. 23, 1427–1435.
6. Deutsch A. and Nilsson R. (1960), Über die säureloslichen Nucleotide der Frauenmilch. Hoppe-Seylers Z. Physiol. Chemie 321, 246–251.
7. Gehrke C. W. and Kuo K. C. (1989), Ribonucleoside analysis by reversed phase high-performance liquid chromatography. J. Chromatogr. 471, 3–36.
8. Sander G., Wieland J., Topp H., Heller-Schöch G., Erb N. and Schöch G. (1985), An improved method for the simultaneous analysis of normal and modified urinary nucleosides and nucleobases by high-performance liquid chromatography. Clin. Chim. Acta 152, 355–361.
9. Sander G., Hülsemann J., Topp H., Heller-Schöch G. and Schöch G. (1986), Protein and RNA turnover in preterm infants and adults: a comparison based on urinary excretion of 3-methylhistidine and of modified one-way RNA catabolites. Ann. Nutr. Metab. 30, 137–142.
10. Schlimme E., Boos K. S. and Weise M. (1981), Selektive Charakterisierung von N1-Methyladenosin neben N7-Methylguanosin im Harn. Clin. Chem. Clin. Biochem. 19, 55–60.
11. Schlimme E., Boos K. S., Frister H., Papst K., Raezke K.-P. and Wilmers B. (1986), Gruppenselektive Hochleistungsflüssigkeitschromatographie von Ribonucleosiden in Milch. Milchwissenschaft 41, 757–762.
12. Schlimme E., Boos K. S., Hagemeier E., Kemper K., Meyer U., Hobler H., Schnelle T. and Weise M. (1986), Direct clean-up and analysis of ribonucleosides in physiological fluids, J. Chromatogr. 378, 349–360.
13. Schlimme E., Boos K. S., Wilmers B. and Gent H. J. (1987), Analysis of ribonucleosides in human body fluids and their possible role as pathobiochemical markers. In: Human Tumor Markers (F. Cimino, G. D. Birkmayer, J. V. Klavins, E. Pimentel and F. Salvatore, eds.). W. de Gruyter Verlag, Berlin, New York, pp. 503–517.
14. Schlimme E. and Boos K. S. (1990), Ribonucleosides in body fluids - on-line chromatographic clean-up and analysis by a column-switching technique. In: Modified Nucleosides in Cancer and Normal Metabolism (C. W. Gehrke and K. C. Kuo, eds.). Journal of Chromatography Library, Vol. 45c. Elsevier Publishers, Amsterdam, pp. C115-C145.
15. Schlimme E., Boos K. S., Schwarzenau E., Frister H., Ott F. G., Raezke K. P. and Wilmers B. (1990), Dual column HPLC analysis of modified ribonucleosides as urinary pathobiochemical markers in clinical research. Nucleosides & Nucleotides 9, 407–410.
16. Schlimme E., Raezke K. P. and Ott F. G. (1991), Ribonucleosides as minor milk constituents, Z. Ernährungswiss. 30, 138–152.
17. Schlimme E., Raezke K. P., Ott F. G. and Schneehagen K. (1993), Ribonucleosides as minor milk constituents: Dependence of nucleoside composition on mammalian species and lactation stage. In: Proc. of the Workshop on Nutritional and Biological Significance of Dietary Nucleotides and Nucleic Acids (A. Gil. ed.). Granada. September 14–16, 1993, in press.
18. Schlimme E., Ott F. G. and Kiesner C. (1994), Reaction kinetics of the heat-induced formation of N6-methyl-adenosine in milk. Int. Dairy Journal 4, 617–627.
19. Schneehagen K. and Schlimme E. (1992), Ribonucleoside - minore Inhaltsstoffe der Humanmilch. Kieler Milchwirtsch. Forsch. Ber. 44, 67–74.
20. Gehrke C. W. and Kuo K. C. T. (eds.) (1990), Chromatographic and Modification of Nucleosides; Part C: Modified Nucleosides in Cancer and Normal Metabolism. Journal of Chromatography Library, Vol. 45 c. Elsevier Publishers, Amsterdam, 452
21. Gil A. and Sanchez-Medina F. (1981), Acid-soluble nucleotides of cow’s, goat’s and sheep’s milks at different stages of lactation. J. Dairy Res. 48, 35–44.
22. Gil A., Lozano E., De-Lucchi C., Maldonado J., Molina J. A. and Pita M. (1988), Changes in the fatty acid profiles of plasma lipid fractions induced by dietary nucleotides in infants born at term. Eur. J. Clin. Nutr. 42, 473–481.
23. GroB H., Topp H., Heller-Schoch G. and Schoch G. (1992), Modifizierte Ribonucleoside in Frauenmilch. Ernährungsumschau 39, 21.
24. Johke T. and Goto T. (1962), Acid-soluble nucleotides in cow’s and goat’s milk. J. Dairy Sci. 45, 735–741.
25. Larson B. L. (1976), Comparative production of β-lacto-globulin and orotic acid with lactose in bovine mammary cell cultures: effects of cell density and constituent inhibition. J. Dairy Sci. 59, 1881–1889.
26. Manson W. (1956), Acid-soluble nucleotides of lactating mammary gland. Biochim. Biophys. Acta 19, 398–399.
27. Martin D. and Schlimme E. (1994), Preparation of ureidonucleosides of the threonine isomers. Z. Naturforsch. 49c, 834–842.
28. Ott F. G. and Schlimme E. (1991), Thermisch induzierte Bildung von N6-Methyladenosin in Milch. Kieler Milchwirtsch. Forsch. Ber. 43, 213–217.
29. Quan R. Barness L. A. and Uauy R. (1990), Do infants need nucleotide supplemented formula for optimal nutrition? J. Pediatr. Gastroenterol. Nutr. 11, 429–434.
30. Raezke K.-P. and Schlimme E. (1990), Ribonucleoside in Milch: Charakterisierung und Bestimmung des Konzentrationsprofils dieser minoren Komponenten Schneehagen K. (1993), Dissertation: Ribonucleoside und Molkenproteine in Humanmilch der frühen und reifen Laktationsphase - Strukturelle Zuordnung und physiologisch-chemische Aspekte. Universitat Kiel.
31. Schoch G., Sander G., Heller-Schöch G., Topp H. and Telaar B. (1988), Protein- und RNA-Umsatz bei Frühgeborenen. In: Protein in der Sauglingsernahrung (F. Haschke, ed.). Ferd. Enke Verlag, Stuttgart, pp. 26–39.
32. Schoch G., Topp H., Held A., Heller-Schoch G., Ballauff A., Manz F. and Sander G. (1990), Interrelation between whole-body turnover rates of RNA and protein. Eur. J. Clin. Nutr. 44, 647–658.
33. Schwarzenau E., Schlimme E., Boos K. S., Ott F. G., Raezke K. R., Wilmers B., Hilfrich J. and Schneider J. (1990), Ribonucleosidausscheidungsmuster im Harn bei Patientinnen mit Mammakarzinom. Tumor Diagn. & Ther. 11, 198–203.
34. Tiemeyer W., Stohrer M. and Giesecke D. (1984), Metabolites of nucleic acids in bovine milk, J. Dairy Sci. 67, 723–728.
35. Tiffany B. C., Wright J. B., Moffett R. B., Heinzelmann R. V., Strube R. E., Aspergen B. D., Lincoln E. H. and White J. L. (1957), Antiviral compounds, I. Aliphatic glyoxals, α-hydroxyaldehydes and related compounds, J. Am. Chem. Soc. 79, 1682–1687.
36. Topp H., Groß H., Heller-Schöch G. and Schöch G. (1993), Determination of N6-threoninocarbonyladenosine, N2, N2-dimethylguanosine, pseudouridine and other ribonucleosides in human breast milk. Nucleosides & Nucleotides 12, 585–596.
37. Ziv G. and Sulman F. G. (1975), Absorption of antibiotics by the bovine udder, J. Dairy Sci. 58, 1637–1644.
38. Ziv G. and Heavner J. E. (1984), Permeability of the blood-milk barrier to methylene blue in cows and goats, J. Vet. Pharmacol. Therap. 7, 55–59.