The nature of learning and memory impairments in schizophrenia

Journal of the International Neuropsychological Society

Volumn 1, Issue 1, 1995, Pages 88-99

  Paulsen, Jane S ^a,b   Heaton, Robert K ^b   Sadek, Joseph R ^b   Perry, William ^b   Delis, Dean C ^a,b   Braff, David ^b   Kuck, Julie ^b   Zisook, Sidney ^b   Jeste, Dilip V ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Learning; Memory; Schizophrenia

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; AMNESIA; ARTICLE; COMPARATIVE STUDY; FEMALE; HUMAN; HUNTINGTON CHOREA; LEARNING; LEARNING DISORDER; LONG TERM MEMORY; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; RECALL; SCHIZOPHRENIA;

ADULT; AGED; ALZHEIMER DISEASE; AMNESIA; FEMALE; HUMANS; HUNTINGTON DISEASE; LEARNING DISORDERS; MALE; MENTAL RECALL; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; RETENTION (PSYCHOLOGY); SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; VERBAL LEARNING;

EID: 0029171196     PISSN: 13556177     EISSN: 14697661     Source Type: Journal    
DOI: 10.1017/S135561770000014X     Document Type: Article

References (70)

1. American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed. rev.). Washington, DC: Author.
2. Andreascn, N.C.,&Olsen, S. (1982). Negative versus positive schizophrenia: Definition and validation.Archives of General Psychiatry, 39, 789–94.
3. Andrew, S.E., Goldberg, P., Kremer, B., Telcnius, H., Theil-mann.J., Adam, S., Starr, E., Squitieri, F., Lin, B., Kalchman, M.A., et al. (1993). The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease.Nature Genetics, 4, 398–403.
4. Baker, L., Cheng, L.,&Amara, I. (1983). The withdrawal of benztropine mesylate in chronic schizophrenic patients.British Journal of Psychiatry, 143, 584–590.
5. Bartus, R.T., Dean, R.L., Beer, B.,&Lippa, A.S. (1982). The cholinergic hypothesis of geriatric memory dysfunction.Science, 217, 408–417.
6. Beatty, W.W., Jocic, Z., Monson, N.,&Staton, D. (1993). Memory and frontal lobe dysfunction in schizophrenia and schizoaffective disorder. Journal of Nervous and Mental Disease, 181, 448–453.
7. Bilder, R.M., Turkel, E., Lipschutz-Broch, L.,&Lieberman, J.A. (1992). Antipsychotic medication effects on neuropsychological functions.Psychopharmacology Bulletin, 28, 353–366.
8. Bogerts, B., Ashtari, M., Degreeef, G., Alvir, J., Bilder, R.M.,&Lieberman, J.A. (1990). Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia.Psychiatry Research: Neuroimaging, 35,.1-13.
9. Bogerts, B., Meertz, E.,&Schonfeldt-Bausch, R. (1985). Basal ganglia and limbic system pathology in schizophrenia: A morphometric study of brain volume and shrinkage.Archives of General Psychiatry, 42, 784–791.
10. Brown, R., Colter, N., Corsellis, J., Crow, F.J., Frith, C.D., Jagoe, R., Johnstone, E.C.,&Marsh, L. (1986). Postmortem evidence of structural brain changes in schizophrenia: Differences in brain weight, temporal horn area, and para-hippocampal gyms compared with affective disorder.Archives of General Psychiatry, 43, 36–42.
11. Butters, N., Granholm, E., Salmon, D.P.,&Grant, I. (1987). Episodic and semantic memory: A comparison of amnesic and demented patients. Journal of Clinical and Experimental Neuropsychology, 9, 479–497.
12. Calev, A. (1984a). Recall and recognition in chronic nonde-mented schizophrenics: The use of matched tasks. Journal of Abnormal Psychology, 93, 172–177.
13. Calev, A. (1984b). Recall and recognition in mildly disturbed schizophrenia: The use of matched tasks.Psychological Medicine, 14, 425–429.
14. Calev, A., Venables, P.H.,&Monk, A.F. (1983a). Schizophrenia tendencies and memory deficits in normals.Personal Individual Differences, 4, 89–94.
15. Calev, A., Venables, P.H.,&Monk, A.F. (1983b). Evidence for distinct verbal memory pathologies in severely and mildly disturbed schizophrenics.Schizophrenia Bulletin, 9, 247–264.
16. Cassens, G., Inglis, A.K., Appelbaum, P.S.,&Gutheil, T.G. (1990). Neuroleptics: Effects on neuropsychological function in chronic schizophrenic patients.Schizophrenia Bulletin, 16, 477–499.
17. Clare, L., McKenna, P.J., Mortimer, A.M.,&Baddeley, A.D. (1993). Memory in schizophrenia: What is impaired and what is preserved? Neuropsychologia, 31, 1225–1241.
18. Crosson, B., Novack, T.A., Trenerry, M.R.,&Craig, P.L. (1988). California Verbal Learning Test (CVLT) performance in severely head-injured and neurologically normal adult males. Journal of Clinical and Experimental Neuropsychology, 10, 754–768.
19. Delis, D.C., Kramer, J.H., Kaplan, E.,&Ober, B.A. (1987). California Verbal Learning Test (CVLT) manual. New York: The Psychological Corporation.
20. Delis, D.C., Massman, P.J., Butters, N., Salmon, D.P., Cermak, L.S.,&Kramer, J.H. (1991). Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders.Psychological Assessment: A Journal of Consulting and Clinical Psychology, 3, 19–26.
21. Drachman, D.A.,&Leavitt, J. (1972). Memory impairment in the aged: Storage versus retrieval deficit. Journal of Experimental Psychology, 93, 302.
22. Dupont, R.M., Jemigan, T.L., Butters, N., Delis, D.C., Hesselink, J., Heindel, W.C., Gillin, J.C. (1990). Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging: Clinical and neuropsychological significance.Archives of General Psychiatry, 47, 55 - 59.
23. Eitan, N., Levin, Y., Ben-Artzi, E., Levy, A., Neumann, M. (1992). Effects of antipsychotic drugs on memory functions of schizophrenic patients.Acta Psychiatric Scandinavia, 85, 14–16.
24. Fuld, P.A., Katzman, R., Davies, P.,&Terry, R.D. (1982). Intrusions as a sign of Alzheimer dementia: Chemical and pathological verification.Annals of Neurology, 11, 155–159.
25. Gold, J.M., Goldberg, T.E., Kleinman, J.E., Weinberger, D.R., Mohr, E., Prouwers, P. (Eds.). (1991). The impact of symptomatic state and pharmacological treatment on cognitive functioning of patients with schizophrenia and mood disorders. Handbook of clinical trials: The neurobehavioral approach. Amsterdam: Swets&Zeitlinger.
26. Gold, J.M., Randolph, C., Carpenter, C.J., Goldberg, T.E.,&Weinberger, D.R. (1992). Forms of memory failure in schizophrenia. Journal of Abnormal Psychology, 101, 487–494.
27. Goldberg, T.E., Greenberg, R.D., Griffin, S.J., Gold, J.M., Kleinman, J.E., Pickar, D., Schulz, S.C., Weinberger D.R. (1993). The effect of clozapine on cognition and psychiatric symptoms in patients with schizophrenia.British Journal of Psychiatry, 162, 43–48.
28. Goldberg, T.E., Weinberger, D.R., Pliskin, N.H., Berman, K.F., 8c Podd, M.H. (1989). Recall memory deficit in schizophrenia: A possible manifestation of prefrontal dysfunction.Schizophrenia Research, 2, 251–257.
29. Goldman-Rakic, P.S., Funahashi, S.,&Bruce, C.J. (1990). Neocortical Memory Circuits.Quarterly Journal of Quantitative Biology, 55, 1025–1038.
30. Goldman-Rakic, P.S., Lidow, M.S., Smiley, J.F.,&Williams, S.M. (1992). The anatomy of dopamine in monkey and human prefrontal cortex. Journal of Neural Transmission, 36, 163–179.
31. Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery&Psychiatry 23, 56–62.
32. Heaton, R., Paulsen, J., McAdams, L.A., Kuck, J., Zisook, S., Braff, D., Harris, M.J.,&Jeste, D.V. (1994). Neuropsychological deficits in schizophrenia: Relationship to age, chronicity and dementia.Archives of General Psychiatry, 51, 469–476.
33. Heinrichs, R.W. (1993). Schizophrenia and the brain: Conditions for a neuropsychology of madness.American Psychology, March, 221–233.
34. Hermann, B.P., Wyler, A.R., Richey, E.T.,&Rea, J.M. (1987). Memory function and verbal learning ability in patients with complex partial seizures of temporal lobe origin.Epilepsia, 28, 547–554.
35. Hunter, A., Tsilfidis, C., Mettler, G., Jacob, P., Mahadevan, M., Surh, L.,&Korneluk, R. (1992). The correlation of age of onset with CTG trinucleotide repeat amplification in myotonic dystrophy. Journal of Medical Genetics, 29, 774 - 779.
36. Jeste, D.V., Harris, M.J., Krull, A., Kuck, J., McAdams, L.A.,&Heaton, R. (in press). Late-onset schizophrenia: Clinical and neuropsychological characteristics.American Journal of Psychiatry.
37. Jeste, D.V., Paulsen, J., Harris, M.J., Bloom, F.L.,&Kupfer, D.J. (Eds.). (in press). Late-onset schizophrenia and other related psychoses. Psychopharmacology: The fourth generation of progress. New York: Raven Press.
38. Jeste, D.V.,&Wyatt, R.J. (1982). Understanding and treating tardive dyskinesia. New York: Guilford Press.
39. Kinsboume, M., Hicks, R.E.,&Requin, J. (Eds.). (1978). Functional cerebral space: A model for overflow, transfer and interference effects in human performance. Attention and performance, VII (pp. 345–362). Hillsdale: Erlbaum.
40. Koh, S.D., Kayton, L.,&Schwartz, C. (1974). The structure of word storage in the permanent memory of non-psychotic schizophrenics. Journal of Consulting and Clinical Psychology, 42, 879–887.
41. Koh, S.D.,&Peterson, R.A. (1978). Encoding orientation and the remembering of schizophrenic young adults. Journal of Abnormal Psychology, 87, 303–313.
42. Kramer, J.H., Delis, D.C., Blusewicz, M.J., Brandt, J., Ober, B.A.,&Strauss, M. (1988). Verbal memory errors in Alzhei-mer's and Huntington's dementias.Developmental Neuropsychology, 4, 1–15.
43. Kramer, J.H., Levin, B., Brandt, J.,&Delis D.C. (1989). Differentiation of Alzheimer's, Huntington's and Parkinson's diseases on the basis of verbal learning characteristics.Neuropsychology, 3, 111–120.
44. Levin, S. (1984). Frontal lobe dysfunctions in schizophrenia II. Impairments of psychological and brain functions. Journal of Psychiatric Research, 18, 57–72.
45. Levin, S., Yurgelun-Todd, D.,&Craft, S. (1989). Contributions of clinical neuropsychology to the study of schizophrenia. Journal of Abnormal Psychology, 98, 341–356.
46. Massman, P.J., Delis, D.C., Butters, N., Dupont, R.M.,&Gil-lin, J.C. (1992). The subcortical dysfunction hypothesis of memory deficits in depression: Neuropsychological validation in a subgroup of patients. Journal of Clinical and Experimental Neuropsychology, 14, 687–706.
47. Massman, P.J., Delis, D.C., Butters, N., Levin, B.E.,&Salmon, D.P. (1990). Are all subcortical dementias alike? Verbal learning and memory in Parkinson's and Huntington's disease patients. Journal of Clinical and Experimental Neuropsychology, 12, 729–744.
48. Medalia, A., Gold, J.,&Merriam, A. (1988). The effects of neu-roleptics on neuropsychological tests results of schizophrenics.Archives of Clinical Neuropsychology, 3, 249–271.
49. Myers, R.H., Madden, J.J., Teague, J.L.,&Falek, A. (1982). Factors related to onset age in Huntington's disease.American Journal of Human Genetics, 34, 481–488.
50. Overall, J.E. (1988). The Brief Psychiatric Rating Scale (BPRS): Recent developments in ascertainment and scaling.Psychopharmacology Bulletin, 24, 97–99.
51. Patterson, T. (1987). Studies toward the subcortical pathogenesis of schizophrenia.Schizophrenia Bulletin, 13, 555–576.
52. Paulsen, J.S., Heaton, R.K.,&Jeste D.V. (1994). Neuropsychological impairment in tardive dyskinesia.Neuropsychology, 8, 227–241.
53. Peavy, G., Jacobs, D., Salmon, D.P., Butters, N., Delis, D.C., Taylor, M., Massman, P., Stout, J.C., Heindel, W.C., Kir-son, D.et al., (1994). Verbal memory performance of patients with Human Immunodeficiency Virus infection: Evidence of subcortical dysfunction. Journal of Clinical and Experimental Neuropsychology, 16, 508–523.
54. Penney, J.B.,&Young, A.B. (1983). Speculations on the functional anatomy of basal ganglia disorders.Annual Review of Neuroscience, 6, 73–94.
55. Perlick, D., Stastny, P., Katz, I., Mayer, M.,&Mattis, S. (1986). Memory deficits and antichotinergic levels in chronic schizophrenia.American Journal of Psychiatry, 143, 230–232.
56. Randolph, C., Goldberg, T.E.,&Weinberger, D.R. (1994). The neuropsychology of schizophrenia (pp. 499–521). Hillsdale, NJ: Erlbaum.
57. Russell, P.N.,&Beekhuis, M.E. (1976). Organization in memory: A comparison of psychotics and normals. Journal of Abnormal Psychology, 85, 527–534.
58. Saykin, A.J., Gur, R.C., Gur, R.E., Mozley, P.D., Mozley, L.H., Resnick, S.M., Kester, B., &Stafiniak, P. (1991). Neuropsychological function in schizophrenia: Selective impairment in memory and learning.Archives of General Psychiatry, 48, 618–624.
59. Schwartz, B.L., Rosse, R.B.,&Deutsch, S.I. (1992). Toward a neuropsychology of memory in schizophrenia.Psychopharmacology Bulletin, 28, 341–351.
60. Spitzer, M. (1993). The psychopathology, neuropsychology, and neurobiology of associative and working memory in schizophrenia.European Archives of Psychiatry and Clinical Neuroscience, 243, 57–70.
61. Spitzer, R.L., Williams, J.B.W., Gibbon, M. (1990). User's guide for the structures clinical interview for DSM-III-R. Washington, D.C.: American Psychiatry Press.
62. Spohn, H.E.,&Strauss, M.E. (1989). Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia. Journal of Abnormal Psychology, 98, 367–380.
63. Squire, L.R. (1992). Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.Psychological Review, 99, 195–231.
64. Swerdlow, N.R.,&Koob, G.F. (1987). Dopamine, schizophrenia, mania and depression: Toward a unified hypothesis of cortico-striato-pallido-thalamic function.Behavioral and Brain Sciences, 10, 197–245.
65. Tamlyn, D., McKenna, P.J., Mortimer, A.M., Lund, C.E., Hammond, S.,&Baddeley, A.D. (1992). Memory impairment in schizophrenia: Its extent, affiliations and neuropsychological character.Psychological Medicine, 22, 101–115.
66. Traupmann, K.L. (1975). Effects of categorization and imagery on recognition and recall by process and reactive schizophrenics. Journal of Abnormal Psychology, 84, 307–314.
67. Traupmann, K.L. (1980). Encoding processes and memory for categorically related words by schizophrenic patients. Journal of Abnormal Psychology 89, 704–716.
68. Weinberger, D.R. (1987). Implications of normal brain development for the pathogenesis of schizophrenia.Archives of General Psychiatry, 44, 660–669.
69. Weinberger, D.R. Berman, K.F.,&Zec, R.F. (1986). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia, I: Regional cerebral blood flow evidence.Archives of General Psychiatry, 43, 114–124.
70. Welsh, K.A., Butters, N., Hughes, J.P., Mohs, R.C.,&Heyman, A. (1991). Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAd neuropsychological measures.Archives of Neurology, 48, 278–281.