The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB

Chemistry and Biology

Volumn 2, Issue 1, 1995, Pages 13-22

  Schmidt, Kerstin N ^a   Amstad, Paul ^b   Cerutti, Peter ^b   Baeuerle, Patrick A ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

catalase; NF B; okadaic acid; superoxide dismutase; TNF

Indexed keywords

CATALASE; DEOXYCHOLIC ACID; DNA; ENZYME INHIBITOR; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OKADAIC ACID; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BIOTRANSFORMATION; CELL CLONE; CYTOLOGY; EPIDERMIS; FLOW CYTOMETRY; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SECOND MESSENGER;

ANIMALS; BIOTRANSFORMATION; CATALASE; CLONE CELLS; DEOXYCHOLIC ACID; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; EPIDERMIS; FLOW CYTOMETRY; HYDROGEN PEROXIDE; MICE; NF-KAPPA B; OKADAIC ACID; SECOND MESSENGER SYSTEMS; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; EUKARYOTA;

EID: 0029170274     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-5521(95)90076-4     Document Type: Article

References (51)

1. Steroid hormone receptors
2. The basics of basal transcription by RNA polymerase II
3. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors
4. The CREB family of transcriptional activators
5. C-terminal phosphorylation of the serum response factor
6. Signaling by the cytokine receptor superfamily: JAKs and STATs
7. The inducible transcription activator NF-KB: regulation by distinct protein subunits
8. NF-κB and rel - participants in a multiform transcriptional regulatory system
9. Function and activation of NFκB in the immune system
10. Activation of DNA-binding in an apparently cytoplasmic precursor of the NF-κB transcription factor
11. IκB: a specific inhibitor of the NF-κB transcription factor
12. NFκB controls expression of inhibitor IκB-α: evidence for an inducible autoregulatory pathway
13. Mutual regulation of the transcriptional activator NF-K13 and its inhibitor IκB-a
14. IκB interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism for cytoplasmic retention
15. Rapid proteolysis of IKB-a is necessary for activation of transcription factor NF-κB
16. A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB
17. Differential interactions of Rel-NF-κB complexes with IκB-α determine pools of consti tutive and inducible NF-κB activity
18. The inhibitory ankyrin and activator Rel proteins
19. The inducible transcription factor NF-κB: structure/function relationship of its protein subunits
20. Proteins controlling the nuclear uptake of NF-κB, Rel and Dorsal
21. Hydrogen peroxide mediates amyloid β protein toxicity
22. Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications
23. A role of oxygen radicals as second messengers
24. NF-KB: an oxidative stress-responsive transcription factor of eukaryotic cells (a review)
25. Redox control of gene expression by eucaryotic transcription factors NFKB, AP-1 and SRF
26. Dithiocarbamates as potent inhibitors of NF-κB activation in intact cells
27. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
28. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1
29. Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus
30. Inhibition of HIV-1 replication and NF-κB activity by cysteine and cysteine derivaties
31. Differential induction of nuclear NF-κB by protein phosphatase inhibitors in primary and transformed human cells
32. The balance between Cu Znsuperoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress
33. Gluthathione peroxidase compensates for the hypersensitivity of Cu, Zn-superoxide dismutase overproducers to oxidant stress
34. Separation of pigmented and albino melanocytes and concomitant evaluation of endogenous peroxide content using flow cytometry
35. Oxidative stress and motorneuron disease
36. Down's syndrome: abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human CuZn-superoxide dismutase
37. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
38. Catalase
39. Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein-1
40. Cytotoxic activity of tumor necrosis factor is mediated by early damage to mitochondrial functions - evidence for the involvement of mitochondrial radical generation
41. Depletion of the mitochondrial electron transport abrogates the Cytotoxic and gene-inductive effects of TNF
42. Modulation of transcription factor NF-κB binding activity by oxidation reduction in vitro
43. Thioredoxin regulates the DNA-binding activity of NF-κB by reduction of a disulfide bond involving cysteine 62
44. Bacterial defenses against oxidative stress
45. Regulation of bacterial oxidative stress genes
46. Human fibroblasts release low amounts of reactive oxygen intermediates in response to the potent phagocyte stimulants serum-treated zymosan, N-formyl-methionyl-leucyl-phenylalanine, leukotriene B4 or 12-O-tetradecanoylphorbol 13-acetate
47. Active oxygen species in the induction of plant systemic acquired resistance by salicylic acid
48. Oxygen and the control of gene expression
49. Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
50. 2+-depen-dence and differential half site recognition