Peptidylproline cis/trans isomerases

Progress in Biophysics and Molecular Biology

Volumn 63, Issue 1, 1995, Pages 67-118

  Galat, Andrzej ^a   Metcalfe, Susan M ^b  

^a DIF   (France)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CYCLOPHILIN; CYCLOSPORIN; DNA BINDING PROTEIN; DNA BINDING PROTEINS; FK 506 BINDING PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEINS; ISOMERASE; POLYENE; RAPAMYCIN; TSUKUBAENOLIDE;

AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; IN VITRO STUDY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN FOLDING; REVIEW; SEQUENCE HOMOLOGY;

AMINO ACID ISOMERASES; AMINO ACID SEQUENCE; ANIMAL; CARRIER PROTEINS; CYCLOSPORINE; DNA-BINDING PROTEINS; HEAT-SHOCK PROTEINS; IN VITRO; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PEPTIDYLPROLYL ISOMERASE; POLYENES; PROTEIN FOLDING; SEQUENCE HOMOLOGY, AMINO ACID; SIROLIMUS; SUPPORT, NON-U.S. GOV'T; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

EID: 0029169643     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/0079-6107(94)00009-X     Document Type: Review

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91. Peptidyl-prolyl cis/trans isomerases and their effectors
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100. Amino acid sequences of two proline-rich bactenecins
101. Specific incorporation of cyclophilin A into HIV-1 virions
102. Calcineurin acts in synergy with PMA to inactivate IκB/MAD3, an inhibitor of NF-κB
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104. Signal transduction events leading to T-cell lymphokine gene expression
105. Isomerase and chaperone activity of prolyl isomerase in the folding of carbonic anhydrase
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107. A Saccharomyces cerevisiae cyclophilin resident in the endoplasmic reticulum
108. Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA
109. Cloning and characterization of cyclophilin C-associated protein: A candidate natural cellular ligand for cyclophilin C
110. Prediction of prolyl residues in cis-conformation in proline structures on the basis of the amino acid sequence
111. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A
112. Cyclophilin B is an abundant protein whose conformation is similar to that of cyclophilin A
113. A rapamycin-selective 25-kDa immunophilin
114. Nuclear protein localization
115. Continuous fluorimetric direct (uncoupled) assay for peptidyl prolyl cis-trans isomerases
116. Structure and expression of cytosolic cyclophilin/peptidyl-prolyl cis-trans isomerase of higher plants and production of active tomato cyclphilin in Escherichia coli
117. Transcriptional activation modulated by homopolymeric glutamine and proline stretches
118. Protein folding in the cell
119. The interleukin 2 CD28-responsive complex contains at least three members of the NF κb family: c-Rel, p50 and p65
120. Separation of drug transport and chloride channel functions of the human MDR P-glycoprotein
121. Characterization of a protein that regulates the DNA-binding activity of NF-AT, the nuclear factor of activated T cells
122. RNase T1 mutant Glu46/Gln binds the inhibitors 2′-GMP and 2′-AMP at the 3′ subunit
123. Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury
124. Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin.
125. Characterization of the human cyclophilin gene and of related processed pseudogenes
126. Complementary DNA for human T-cell cyclophilin
127. Yeast cyclophilin: isolation and characterization of the protein, cDNA and gene
128. 2+ -induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidylprolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase
129. Cyclophilin: a specific cytosolic binding protein for cyclosporin A
130. Isolation and amino acid sequence of cyclophilin
131. A receptor for the immunosuppressant FK-506 is a cis-trans peptidyl-prolyl isomerase
132. Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes
133. Mechanistic studies of enzymatic and nonenzymatic prolyl cis-trans isomerization
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135. Nucleotide sequence of a cDNA coding for mouse cyclophilin
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137. Identification of an autoinhibitory domain in calcineurin
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139. Purification and properties of multiple molecular forms of yeast peptidyl prolyl cis-trans isomerase
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141. Two distinct forms of peptidyl-prolyl cis-trans isomerase are expressed separately in periplasmic and cytoplasmic compartments of Escherichia coli cells
142. FK506-binding protein proline rotamase is a target for the immunosuppressive agent FK506 in Saccharomyces cerevisae
143. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
144. The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae
145. The weak, fine-tuned binding of ubiquitous transcription factors to the Il-2 enhancer contributes to its T cell-restricted activity
146. Cloning and characterization of ppiB, a Bacillus subtilis gene which encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase
147. The multidrug resistance P-glycoprotein
148. Isolation, cDNA sequences, and biochemical characterization of the major cyclosporin-binding proteins from Taxoplasma gondii
149. Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress-inducible yeast protein STI1
150. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein
151. Mapping of the immunophilin-immunosuppressant site of interaction with calcineurin
152. FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function
153. Isolation of mitochondrial cyclophilin from bovine heart
154. Molecular cloning of a complementary DNA to rat cyclophilin-like protein mRNA
155. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state folding
156. Nuclear factor of activated T cells contains Fos and Jun
157. p is a substrate for calcineurin and interacts with Fos and Jun
158. FK506 binding protein associated with the calcium release channel (ryanodine receptor)
159. Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line
160. The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin.
161. Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein FKBP-13
162. Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25
163. The B7 and CD28 receptor families
164. Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
165. Solution structure of FK506 from nuclear magnetic resonance and molecular dynamics
166. Nucleotide sequence of a regulatory region controlling alginate synthesis in Pseudomonas aeruginosa: characterisation of the algR2 gene
167. The role of the leucine zipper in the Fos-Jun interaction
168. Nucleotide sequences of fic and fic-1 genes involved in cell filamentation induced by cyclic AMP in Escherichia coli
169. Inhibition of T lymphocyte activation by the immunosuppressive drug FK506
170. Inhibition of T and B lymphocyte proliferation by rapamycin
171. Similarities and differences between human cyclophilin A and other β-barrel structures
172. Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization
173. Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A
174. Crystal structure of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
175. Effects of an immunosuppressant, FK506, on interleukin 1α production by human macrophages and a macrophage-like cell line, U937
176. Apoptosis, a basic biological phenomenon with wide ranging implications in tissue kinetics
177. Reinvestigation of the conformation of cyclosporin A in chloroform
178. Isolation and characterization of a 40-kDa cyclophilin-related protein
179. Cyclophilin-40, a protein with homology to the p59 component of the steroid receptor complex
180. CsA stimulates proliferation of liver cells after partial heatectomy in rats
181. Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes
182. FK505, A novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics
183. Purification of 3′,5′-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to sepharose
184. Calcineurin
185. Calcineurin: a calcium- and calmodulin-binding protein of the nervous system.
186. Determination of kinetic constants for peptidyl-prolyl cis-trans isomerases by an improved spectrophotometric assay
187. Lithium chloride perturbation of cis-trans peptide bond equilibria: effect on conformation equilibrium in cyclosporin A and on time dependent inhibition of cyclophilin
188. Cyclophilin: distribution and variant properties in normal and neoplastic tissues
189. A Candida albicans homolog of a human cyclophilin gene encodes a peptidyl-prolyl cis-trans isomerase
190. Second cyclophilin-related gene in Saccharomyces cerevisiae
191. The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence
192. Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerse related to human FK506-binding protein
193. Autoantibodies against cyclophilin in systemic lupus erythematosus and Lyme disease
194. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
195. Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex
196. Cyclosporin A FK506 and rapamycin: more than just immunosuppression
197. 1 progression
198. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
199. Molecular cloning and regional distribution of rat brain cyclophilin
200. Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus
201. Catalysis of protein folding by prolyl isomerase
202. Calorimetric and circular dichroic studies of the thermal denaturation of β-lactoglobulin
203. P59, an hsp 90-binding protein
204. The inammalian heat shock protein binding imunophilin (p59/HBI) is an ATP and GTP binding protein
205. IL2 programs mouse ab T lymphocytes for apoptosis
206. Solution structure of FK506 bound to FKBP-12
207. Leukocyte chemotactic activity of FKBP and inhibition by FK506
208. Specific interaction of the cyclophilin-cyclosporin complex with the B subunit of calcineurin
209. Amino acid sequence homology between cyclophilin and a cDNA-cloned antigen of Echinococcus granulosus
210. Prolyl isomerase catalyze antibody folding in vitro
211. Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A
212. Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis
213. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
214. Inhibition of T cell signalling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatases activity
215. Cyclosporin A inhibits an initial step in folding of transferrin within the endoplasmic reticulum
216. Structural characterization of the FK506 binding protein unfolded in urea and guanidine hydrochloride
217. Cycloporin synthase
218. Light-regulated, tissue-specific immunophilins in a higher plant
219. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B
220. Chlamydia trachomatis contains a protein similar to the Legionella pneumophila mip gene product
221. Chlamydia trachomatis Mip-like protein has peptidylprolyl cis/trans isomerase activity that is inhibited by FK506 and rapamycin and is implicated in initiation of chlamydial infection
222. Influence of proline residues on protein conformation
223. Structure of the pleckstrin homology domain from β-spectrin
224. Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin
225. Purification of FKBP-70, a novel immunophilin from Sacchromyces cerevisiae, and cloning of its structural gene, FPR3
226. Effects of abiotic stresses on cyclophilin gene expression in maize and bean and sequence analysis of bean cyclophlin cDNA
227. Inhibition of the immune response by rapamycin, a new antifungal antibiotic
228. Rabbit FKBP59-heat shock protein binding immunophilin (HBI) is a calmodulin binding protein
229. The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes
230. The hepatotrophic influence of cyclosporine
231. Analysis in Neisseria meninigitidis and other Neisseria species of genes homologous to the FKBP immunophilin family
232. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs
233. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
234. The effect of cyclosporine administration on the cellular distribution and content of cyclophilin
235. The yeast cyclophilin multigene family: purification, cloning and characterization of a new isoform
236. Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR
237. Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner
238. Cyclosporine does not prevent cytoplasmic calcium changes associated with lymphocyte activation
239. 1 interface in lymphocyte activation
240. Evidence that FK506 and rapamycin block T cell activation at different sites relative to early reversible phosphorylation involving the protein phosphatases PP1 and PP2A
241. Cyclosporine, FK506 and rapamycin
242. Cyclosporin-A binds lymphocyte surface receptors induced by activation
243. FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal.
244. Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin
245. Conformational analysis of the cis- and trans-isomers of FK506 by NMR and molecular dynamics
246. X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 A resolution
247. X-ray structure of a cyclophilin B/cyclosporin complex: comparison with cyclophilin A and delineation of its calcineurin-binding domain
248. Crystal structure of the trigonal form of bovine beta-lactoglobulin and its complex with retinol at 2.5 A resolution
249. A calcium-dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin
250. Solution structure of the major binding protein for the immunosuppressant FK506
251. The distinct effects of FK506 on the activation, proliferation, and differentiation of human B lymphocytes
252. 1/S-phase growth arrest in T lymphocytes
253. cdc2 kinase activation
254. Rapamycins: Antifungal, antitumor, antiproliferative, and immunosuppressive macrolides
255. Stereochemical quality of protein structure coordinates
256. Amino acid sequence of a 12-kDa inhibitor of protein kinase C
257. Enzymatic catalysis of prolyl isomerization in an unfolding protein
258. FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms
259. Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases
260. Cyclosporin A inhibits growth of autocrine tumor cell lines by destabilizing interleukin-3 mRNA
261. Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high stress conditions
262. Dams and sluices
263. cDNA encoding murine FK506-binding protein (FKBP): nucleotide and deduced amino acid sequences
264. 2+/calmodulin kinase
265. Cyclosporin A modulation of tumor necrosis gene expression and effects in vitro and in vivo
266. Isolation and characterization of STI1, a stress-inducible gene from Saccharomyces cerevisiae
267. Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2
268. Localization of the FK506-binding protein, FKBP13, to the lumen of the endoplasmic reticulum
269. Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex
270. NF-AT components define a family of transcription factors targeted in T-cell activation
271. A nonimmunosuppressive triene-modified rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans isomerase
272. FK-506 and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
273. Yeast sequencing reports: the complete sequence of KB3, a 7.9 kb fragment between PGK1 on chromosome III, reveals the presence of seven open reading frames
274. Genetic dissection of cyclophilin function
275. FK-506-binding proteins from Streptomycetes producing immunosuppressive macrolactones of the FK-506 type
276. Streptomyces chrysomallus FKBP-33 is a novel immunophilin consisting of two FK506 binding domains; its gene is transcriptionally coupled to the FKBP-12 gene
277. Streptomycetes possess peptidyl-prolyl cis-trans isomerases that strongly resemble cyclophilins from eucaryotic organisms
278. cDNA cloning of a putative protochordate FK506-binding protein
279. The structure of β-lactoglobulin and its similarity to plasma retinol-binding protein
280. PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism
281. Saccharomyces cerevisiae contains a homology of human FKBP-13, a membrane-associated FK506/rapamycin binding protein
282. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complex
283. Cancers complicating organ transplantation
284. Neisseria meningitidis C114 contains silent, truncated pilin genes that are homologous to Neisseria gonorrhoeae pil sequences
285. Conformation of two non-immunosuppressive FK506 analogs when bound to FKBP by isotope-filtered NMR
286. X-ray structure of a decameric cyclophilin-cyclosporin crystal complex
287. Arresting developments in cell cycle control
288. A Method for Minimizing a Sum of Squares of Non-Linear Functions Without Calculating Derivatives
289. Receptor regulation of phosphoinositide 3-hydroxykinase in the NG115-401L-C3 neuronal cell line: stimulation by insulin-like growth factor-1
290. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
291. Human cyclophilin B
292. Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A
293. Cis/trans isomerization at proline: desolvation and its consequences for protein folding
294. A novel peptidyl-prolyl cis/trans isomerase from Escherichia coli
295. Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer
296. The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59)
297. Functional complementation of yeast ste6 by a mammalian mdr gene
298. Divergent regulation of phosphatidylinositol 3-kinase P85a and P85 isoforms upon T cell activation
299. The N-terminal cyclophilin-homologous domain of a 150-kilodalton tumor recognition molecule exhibits both peptidylprolyl cis-trans-isomerase and chaperone activity
300. The non-DNA-binding heterooligomeric form of mammalian steroid homrone receptors contains a hsp90-bound 59-kilodalton protein
301. Amino acid preferences for specific locations at the ends of helices
302. On the localization of FKBP25 in T-lymphocytes
303. Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate
304. Improved calcineurin inhibition of yeast FKBP-12-drug complexes
305. Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases
306. Tissue distribution and cellular localization of hsp56, an FK506-binding protein
307. Distribution of the cyclosporine binding protein cyclophilin in human tissues
308. Neisseria meningitidis encodes an FK-506-inhibitable rotamase
309. Hsp56: A novel heat shock protein associated with untransformed steroid receptor complex
310. Immunofluorescent localization and immunochemical determination of cyclophilin-A with specific rabbit antisera
311. Novel immunosuppressive agent FK506 in vitro effects on cloned T cell activation
312. Inducible nuclear factor binding to the κB elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner
313. A homodimer represents an active species of the peptidyl-prolyl cis/trans isomerases FKB25mem from Legionella pneumophilia
314. Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor
315. Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins
316. Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein)
317. Catalysis of protein folding by cyclophilins from different sources
318. Chemistry and biology of the immunophilins and their immunosuppressive ligands
319. The cell cycle, signal transduction, and immunophilin-ligand complexes
320. Murine cyclophilin-S1: a variant peptidyl-prolyl isomerase with putative signal sequence expressed in differentiating F9 cells
321. Costimulation of T-lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
322. Programmed cell death, apoptosis and killer genes
323. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
324. Inhibition of calcineurin by a novel FK-506-binding protein.
325. Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages
326. The ninA gene required for visual transduction in Drosophila encodes a homologue of cyclosporin A-binding protein
327. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
328. The cytosolic-binding protein for the immunosuppressant FK-506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans isomerases
329. Immunophilin mediate the neuroprotective effects of FK506 in focal cerebral ischaemia
330. Cyclosporin A inhibits activation induced cell death in T-cell hybridomas and thymocytes
331. Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK506?
332. Cyclosporin A, FK506, and rapamycin: pharmacologic probes of lymphocyte signal transduction
333. Induction of T cell anergy by altered T-cell receptor ligand on live antigen presenting cells
334. FKBP54, a novel FK506-binding protein in avian progesterone receptor complex and HeLa extracts
335. Controlling signal transduction with synthetic ligands
336. A novel secreted cyclophilin-like protein (SCYLP)
337. The cyclophilin homolog ninaA is a tissue specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsin
338. Molecular cloning and overexpression of the human FK506-binding protein, FKBP
339. FK506 inhibits activation driven T cell death
340. High brain densities of the immunophilin FKBP colocalized with calcineurin
341. Cyclosporin A shows collagen triple-helix formation in vivo: indirect evidence for a physiologic role of peptidyl-prolyl cis-trans isomerase
342. Occurrence and role of cis peptide bonds in protein structure
343. The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.
344. 9k observed by X-ray crystallography
345. Calculation of unbiased first-order rate constants
346. 13
347. The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A
348. Cyclosporin A inhibits T-cell receptor induced IL2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein kinase C isoenzyme, protein kinase C-β
349. p59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptor
350. Potentiation of progesteron receptor-mediated transcription by the immunosuppressant FK506
351. Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
352. Structure of FK506: a novel immunosuppressant isolated from Streptomyces
353. Yeast cyclophilin-related gene encodes a nonessential second peptidyl-prolyl cis-trans isomerase associated with the secretory pathway
354. Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70S6 kinase
355. Isolation and partial characterization of membrane-associated cyclophilin and related 22-kDa glycoprotein
356. Functional association of cyclophilin A with HIV-1 virions
357. Solution structure of the cyclosporin A/cyclophilin complex by NMR
358. cis-Acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1
359. The ryanodine receptor from canine heart sarcoplasmic reticulum is associated with a novel FK-506 binding protein
360. Purification of the 120 kDa component of the human NFAT: reconstitution of binding activity to the cis-activating element of the GM-CSF and IL2 promoter with AP-1
361. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes
362. Chromosomal organization and expression of Escherichia coli pab A
363. Immunological agnosia
364. Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa
365. Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisae
366. Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding
367. Cyclosporins as drug resistance modifiers
368. Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes
369. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
370. Structure of immunophilin-immunosuppressant complex
371. Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin
372. An evolutionary perspective on apoptosis
373. Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens
374. The NMR structure of cyclosporin A bound to cyclophilin in aqueous solution
375. T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases
376. The 3D structure of a cyclosporin analogue in water is nearly identical to the cyclophilin-bound cyclosporin conformation
377. Suppression of B cell activation by cyclosporin A, FK506 and rapamycin
378. KB1 encodes a nonessential FK506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins
379. Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein
380. Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex
381. The kinetics of reversible tight-binding inhibition
382. The structure and function of proline-rich regions in proteins
383. β-turns and their distortions: a proposed new nomenclature
384. An Escherichia coli protein consisting of a domain homologous to FK506-binding proteins (FKBP) and a new metal binding motif
385. Leukocyte chemotactic activity of cyclophilin
386. Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription
387. A composite FKBP-12-FK506 surface that contacts calcineurin
388. The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13
389. An active FK506-binding domain of 17 000 daltons is isolated following limited proteolisis of chicken thymus hsp56
390. Solution structure of a pleckstrin-homology domain
391. Mutagenesis of human cyclophilin A defines the enzyme active site and separate peptidyl-prolyl isomerase activity from cyclosporin-A binding and calcineurin inhibition