High-Affinity ssDNA Inhibitors of the Reverse Transcriptase of Type 1 Human Immunodeficiency Virus

Biochemistry

Volumn 34, Issue 29, 1995, Pages 9599-9610

  Schneider, Daniel J ^a,b   Feigon, Juli ^c   Hostomsky, Zdenek ^d   Gold, Larry ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b GILEAD SCIENCES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d AGOURON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SINGLE STRANDED DNA; VIRUS ENZYME;

ARTICLE; AVIAN MYELOBLASTOSIS VIRUS; BINDING AFFINITY; BINDING SITE; DNA LIBRARY; DNA PROTEIN COMPLEX; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLONEY LEUKEMIA ONCOVIRUS; NONHUMAN; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; BASE SEQUENCE; BINDING SITES; CLONING, MOLECULAR; COMPARATIVE STUDY; DATABASES, FACTUAL; DNA, SINGLE-STRANDED; DRUG DESIGN; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; MAMMARY TUMOR VIRUS, MOUSE; MOLECULAR SEQUENCE DATA; MYELOBLASTOSIS VIRUS, AVIAN; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TEMPLATES, GENETIC;

AVES; AVIAN MYELOBLASTOSIS VIRUS; DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLONEY MURINE LEUKEMIA VIRUS; ONCOVIRINAE;

EID: 0029165745     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00029a037     Document Type: Article

References (36)

1. Altschul, S. F. (1989) J. Theor. Biol. 138, 297-309.
2. Altschul, S. F., & Erickson, B. W. (1986) Bull. Math. Biol. 48, 603-616.
3. Arnold, E., Jacobo-Molina, A., Nanni, R. G., Williams, R. L., Lu, X., Ding, J., Clark, A. D., Zhang, A., Ferris, A. L., Clark, P., Hizi, A., & Hughes, S. (1992) Nature 357, 85-89.
4. Baltimore, D. (1970) Nature 226, 1209.
5. Barat, A., Lullien, V., Schatz, O., Keith, G., Nugeyre, M. T., Gruninger-Leitch, P., Barre-Sinoussi, P., LeOrice, S. P. J., & Darlix, J. L. (1989) EMBO J. 8, 3279-3285.
6. Beese, L. S., Derbyshire, V., & Steitz, T. A. (1993) Science 260, 352-355.
7. Brennan, R. G., Roderick, S. L., Takeda, Y., & Mathews, B. W. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 8165.
8. Carey, J., Cameron, V., de Haseth, P., & Uhlenbeck, O. C. (1983) Biochemistry 22, 2601-2609.
9. Davies, J. P., Hostomska, Z., Hostomsky, Z., Jordan, S. R., & Matthews, D. A. (1991) Science 252, 88-95.
10. Davis, J. P., Janjic, N., Pribnow, D., & Zichi, D. A. (1995) Nucleic Acids Res. (in press).
11. Freemont, P. S., Friedman, J. M., Beese, L. S., Sanderson, M. R., & Steitz, T. A. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 8924-8928.
12. Purfine, E. S., & Reardon, J. E. (1991) J. Biol. Chem. 266, 406-412.
13. Gilboa, E., Mitra, S. W., Goff, S., & Baltimore, D. (1979) Cell 18, 93-100.
14. Gill, S. C., Weitzel, S. B., & von Hippel, P. H. (1991) J. Mol. Biol. 220, 307-324.
15. Goff, S. P. (1990) J. Acquired Immune Defic. Syndr. 3, 817.
16. Gold, L., Pohsky, S., Uhlenbeck, O., & Yarus, M. (1995) Annu. Rev. Biochem. (in press)
17. Hansen, J., Schulze, T., Mellert, W., & Moelling, K. (1988) EMBO J. 7, 239-243.
18. Hostomsky, Z., Hostomska, Z., Hudson, G. O., Moomaw, P. W., & Nodes, B. R. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 1148-1152.
19. Jacobo-Molina, A., Ding, J., Nanni, R., Clark, A., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S., & Arnold, E. (1993) Proc. Natl. Acad. Sci. U.SA. 90, 6320-6324.
20. Jaeger, J. A., Turner, D. H., & Zuker, M. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 7706-7710.
21. Kohlstaedt, L. A., Wang, J., Priedman, J. M., Rice, P. A., & Steitz, T. A. (1992) Science 256, 1783-1790.
22. Krug, M. S., & Berger, S. L. (1991) Biochemistry 30, 10614-10623.
23. Larder, B. A., Purifoy, D. J., Powell, K. L., & Darby, G. (1987) Nature 327, 716.
24. Larder, B. A., Kemp, S. D., & Purifoy, D. J. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 4803.
25. Panet, A., Haseltine, W. A., Baltimore, D., Peters, G., Harada, P., & Dahlberg, J. E. (1975) Proc. Natl. Acad. Sci. U.SA. 72, 2535-2539.
26. Peliska, J. A., & Benkovic, S. J. (1992) Science 258, 1112-1118.
27. Reardon, J. E., Purfine, E. S., & Cheng, N. (1991) J. Biol. Chem. 266, 14128-14134.
28. Richmond, T. J. (1984) Nature 311, 532.
29. Schneider, D., Gold, L., & Platt, T. (1993) FASEB J. 7, 201-207.
30. Schultz, S. C., Shields, G. C., & Steitz, T. A. (1991) Science 253, 1001-1007.
31. Subbiah, S., & Harrison, S. C. (1989) J. Mol. Biol. 209, 539-548.
32. Temin, H. M., & Mizutani, S. (1970) Nature 226, 1211.
33. Tou, J. T., & Gonzales, R. T. (1974) in Pattern Recognition Principles (Kalaba, R., Ed.) pp 86-104, Addison-Wesley Publishing Co., Reading, MA.
34. Tuerk, C., & Gold, L. (1990) Science 249, 505-510.
35. Tuerk, C., MacDougal, S., & Gold, L. (1992) Proc. Nad. Acad. Sci. U.SA. 89, 6988-6992.
36. Zuker, M. (1989) Science 244, 48-52.