Phosphinic Acid Analogues of GABA. 2. Selective, Orally Active GABAB Antagonists

Journal of Medicinal Chemistry

Volumn 38, Issue 17, 1995, Pages 3313-3331

  Froestl, Wolfgang ^a   Mickel, Stuart J ^a   von Sprecher, Georg ^a   Diel, Peter J ^b   Hall, Roger G ^b   Maier, Ludwig ^b   Strub, Dietrich ^a   Melillo, Vito ^a   Baumann, Peter A ^a   Bernasconi, Raymond ^a   Gentsch, Conrad ^a   Hauser, Kathleen ^a   Jaekel, Joachim ^a   Karlsson, Goeril ^b   Klebs, Klaus ^a   Maître, Laurent ^a   Marescaux, Christian ^c   Pozza, Mario F ^a   Schmutz, Markus ^a   Steinmann, Martin W ^a   van Riezen, Henk ^a   Vassout, Annick ^a   Mondadori, Cesare ^a   Olpe, Hans Rudolf ^a   Waldmeier, Peter C ^a   Bittiger, Helmut ^a   more..

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYSACLOFEN; 3 AMINOPROPANEPHOSPHINIC ACID; 3 AMINOPROPYL(BUTYL)PHOSPHINIC ACID; 3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 3 AMINOPROPYL(ETHYL)PHOSPHINIC ACID; 3 AMINOPROPYL(METHYL)PHOSPHINIC ACID; 3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 5 HYDROXYTRYPTOPHAN; 5,7 DICHLOROKYNURENIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BACLOFEN; CGP 36216; CLONIDINE; CYCLOHEXYLADENOSINE; DOXEPIN; FLUNITRAZEPAM; GABOXADOL; GLUTAMIC ACID; GRANISETRON; KAINIC ACID; KETANSERIN; MUSCIMOL; NALOXONE; PHACLOFEN; PHOSPHINIC ACID DERIVATIVE; PRAZOSIN; QUINUCLIDINYL BENZILATE; RECEPTOR SUBTYPE; SACLOFEN; SUBSTANCE P; TIOTIDINE; UNCLASSIFIED DRUG;

ABSENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; BLOOD BRAIN BARRIER; BRAIN MEMBRANE; BRAIN SLICE; COGNITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; INHIBITORY POSTSYNAPTIC POTENTIAL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEARNING; LONG TERM POTENTIATION; MEMORY; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMNESIA; ANIMAL; CEREBRAL CORTEX; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; IN VITRO; LEARNING; LONG-TERM POTENTIATION; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHINIC ACIDS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029165253     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00017a016     Document Type: Article

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