The T protein encoded by Brachyury is a tissue-specific transcription factor

EMBO Journal

Volumn 14, Issue 19, 1995, Pages 4763-4772

  Kispert, Andreas ^a,b   Koschorz, Birgit ^a,c   Herrmann, Bernhard G ^a,c  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

^b HARVARD UNIVERSITY   (United States)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Brachyury; Embryogenesis; Mesoderm; Mouse; Transcription factor

Indexed keywords

DNA BINDING PROTEIN; GLYCINE CLEAVAGE SYSTEM; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; REPORTER GENE; TRANSACTIVATION;

ANIMALIA;

EID: 0029165111     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1995.tb00158.x     Document Type: Article

References (51)

1. Agulnik,S.I., Bollag,R.J. and Silver,L.M (1995) Conservation of the T-box gene family from Mus musculus to Caenorhahditis elegans. Genomics, 25, 214-219.
2. Bollag,R.J., Siegfried,Z., Cebra-Thomas,J., Garvey,N., Davison,E.M. and Silver,L.M. (1994) An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T-locus. Nature Genet., 7, 383-389.
3. Carey,M. (1991) Mechanistic advances in eukaryotic gene activation. Curr. Opin. Cell. Biol., 3, 452-460.
4. Chesley,P. (1935) Development of the short-tailed mutant in the house mouse. J. Exp. Zool., 70, 429-435.
5. Courey,A.J. and Tjian,R. (1988) Analysis of SP1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell, 55, 887-898.
6. Cunliffe,V. and Smith,J.C. (1994) Specification of mesodermal pattern in Xenopus laevis by interaction between Brachyury, noggin and XWnt-8. EMBO J., 13, 349-359.
7. Dingwall,C. and Laskey,R.A. (1991) Nuclear targeting sequences - a consensus? Trends Biochem. Sci., 12, 478-481.
8. Dobrovolskaia-Zavadskaia,N. (1927) Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existence d'un caractere hereditaire 'non viable'. C.R. Hebd. Seanc. Soc. Biol., 97, 114-116.
9. Frankel,A.D. and Kim,P.S. (1991) Modular structure of transcription factors: implications for gene regulation. Cell, 65, 717-719.
10. Garcia-Bustos,J., Heitman,J. and Hall,M.N. (1991) Nuclear protein localization. Biochim. Biophys. Acta, 1071, 83-101.
11. Gorman,C.M., Moffrat,L.F. and Howard,B.H. (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol., 2, 1044-1051.
12. Graham,F. and van der Eb,A. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52, 456-457.
13. Hall,C.V. (1982) Expression and regulation of Escherichia coli lacZ fusions in mammalian cells. J. Mol. Appl. Genet., 2, 101-109.
14. Harrison,S.C. (1991) A structural taxonomy of DNA-binding domains. Nature, 353, 715-719.
15. Wis mutant embryos. Development, 113, 913-917.
16. Herrmann,B.C. and Kispert,A. (1994) The T genes in embryogenesis. Trends Genet., 8, 280-286.
17. Herrmann,B.G., Labeit,S., Poustka,A., King,T.R. and Lehrach,H. (1990) Cloning of the T gene required in mesoderm formation in the mouse. Nature, 343, 617-622.
18. Hollenberg,S.M. and Evans,R.M. (1988) Multiple and cooperative transactivation domains of the human glucocorticoid receptor. Cell, 61, 1021-1033.
19. Hope,I.A. and Struhl,K. (1986) Functional dissection of a eukaryotic transcriptional activator, GCN4 of yeast. Cell, 46, 885-894.
20. Hwang,J.-J., Chambon,P. and Davidson,I. (1993) Characterization of the transcription activation function and the DNA binding domain of the transcriptional enhancer factor-1. EMBO J., 12, 2337-2348.
21. Johnson,P.F. and McKnight,S.L. (1989) Eukaryotic transcriptional regulatory proteins. Annu. Rev. Biochem., 58, 799-839.
22. Kalderon,D., Richardson,W.D., Markham,A.T. and Smith,A.E. (1984) Sequence requirements for nuclear location of simian virus 40 large T-antigen. Nature, 311, 33-38.
23. Kispert,A. and Herrmann,B.G. (1993) The Brachyury gene encodes a novel DNA-binding protein. EMBO J., 12, 3211-3220, 4898-4899.
24. Kispert,A. and Herrmann,B.G. (1994) Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos. Dev. Biol., 161, 179-193.
25. Kispert,A., Herrmann,B.G., Leptin,M. and Reuter,R (1994) Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta. Genes Dev., 8, 2137-2150.
26. Kispert,A., Ortner,H., Cooke,J. and Herrmann,B.G. (1995) The chick Brachyury gene: developmental expression pattern and response to axial induction by localized activin. Dev. Biol., 168, 406-415.
27. Kissinger,C.R., Liu,B., Martin-Blanco,E., Kornberg,T.B. and Pabo,C.O. (1990) Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions. Cell, 63, 579-590.
28. Klein-Hitpass,L., Schorpp,M., Wagner,U. and Ryffel,G.U. (1986) An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Cell, 46, 1053-1061.
29. Lai,E., Prezioso,V.R., Tao,W., Chen,W. and Darnell,J.E.,Jr (1991) Hepatocyte nuclear factor 3a belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene forkhead. Genes Dev., 5, 416-427.
30. MacGregor,G.R. and Caskey,C.T. (1989) Construction of plasmids that express E.coli β-galactosidase in mammalian cells. Nucleic Acids Res., 17, 2365.
31. Mermod,N., O'Neil,E.A., Kelley,T.J. and Tjian,R. (1989) The proline-rich transcriptional activator of CTF/NF-1 is distinct from the replication and DNA binding domain. Cell, 58, 741-753.
32. Mitchell,P.J. and Tjian,R. (1989) Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science, 245, 371-378.
33. Nagpal,S., Friant,S., Nakshatri,H. and Chambon,P. (1993) RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo. EMBO J., 12, 2349-2360.
34. Nye,J., Petersen,J.M., Gunther,C.V., Jonson,M.D. and Graves,B.J. (1992) Interaction of murine Ets-1 with GGA-binding sites establishes the ETS domain as a new DNA binding motif. Genes Dev., 6, 975-990.
35. Pani,L., Overdier,D.G., Porcella,A, Qian,X., Lai,E. and Costa,R.H. (1992) Hepatocyte nuclear factor 3b contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein. Mol. Cell. Biol., 12, 3723-3732.
36. Pflugfelder,G.O., Roth,H. and Poeck,B. (1992) A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding. Biochem. Biophys. Res. Commun., 196, 918-925.
37. Qian,Y.Q., Billeter,M., Otting,G., Müller,M., Gehring,W.J. and Wuthrich,K. (1989) The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors. Cell, 59, 573-580.
38. Rao,Y. (1994) Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor. Genes Dev., 8, 939-947.
39. Schulte-Merker,S., Ho,R.K., Herrmann,B.G. and Nüsslein-Volhard,C. (1992) The protein product of the zebrafish homologue of the mouse T gene is expressed in nuclei of the germ ring and the notochord of the early embryo. Development, 116, 1021-1032.
40. Smith,J.C., Price,B.M.J., Green,J.B.A., Weigel,D. and Herrmann,B.G. (1991) Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell, 67, 79-87.
41. Stunnenberg,H.G. (1993) Mechanisms of transactivation by retinoic acid receptors. BioEssays, 15, 309-315.
42. Treisman,R. and Ammerer,G. (1992) The SRF and MCM1 transcription factors. Curr. Opin. Genet. Dev., 2, 221-226.
43. Treisman,R., Harris,E. and Desplan,C. (1991) The paired box encodes a second DNA-binding domain in the paired homeodomain protein. Genes Dev., 5, 594-604.
44. Wasylyk,C., Kerckaert,J.P. and Wasylyk,B. (1992) A novel modulator domain of Ets transcription factors. Genes Dev., 6, 965-974.
45. Webster,N.J.G., Green,S., Jin,J.R. and Chambon,P. (1988) The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell, 54, 199-207.
46. Weigel,D. and Jäckle,H. (1990) fork head: a new eukaryotic DNA binding motif? Cell, 63, 455-456.
47. Wilkinson,D.G., Bhatt,S. and Herrmann,B.G. (1990) Expression pattern of the mouse T gene and its role in mesoderm formation. Nature, 343, 657-659
48. Xiao,J.H., Davidson,I., Matthes,H., Wintzerith,M., Schatz,C., Wildemann,A. and Chambon,P. (1991) Cloning, expression, and transcriptional activation properties of human enhancer factor TEF-1, Cell, 65, 551-568.
49. Xu,W., Rould,M.A., Jun,S. Desplan,C. and Pabo,C.O. (1995) Crystal structure of a paired domain-DNA complex at 2.5 Å resolution reveals structural basis for Pax developmental mutations. Cell, 80, 639-650.
50. Yasuo,H. and Satoh,N. (1993) Function of vertebrate T gene. Nature, 364, 582-583.
51. Yasuo,H. and Satoh,N. (1994) An ascidian homolog of the mouse Brachyury (T) gene is expressed exclusively in notochord cells at the fate restricted stage. Dev. Growth Differ., 36, 9-18.