Active site residues in m-calpain: identification by site-directed mutagenesis

FEBS Letters

Volumn 368, Issue 3, 1995, Pages 397-400

  Arthur, J Simon C ^a   Gauthier, Sherry ^a   Else, John S ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Ca2+ binding; Calpain; Catalytic triad; Cysteine proteinase; Mutagenesis

Indexed keywords

ALANINE; ASPARAGINE; CALPAIN; CALPAIN II; CYSTEINE; CYSTEINE PROTEINASE; DIMER; HISTIDINE; MUTANT PROTEIN; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; LIGHT SCATTERING; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ANIMAL; BINDING SITES; CALCIUM; CALPAIN; CLONING, MOLECULAR; ESCHERICHIA COLI; HUMAN; MUTAGENESIS, SITE-DIRECTED; RATS; SUPPORT, NON-U.S. GOV'T;

EID: 0029165075     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(95)00691-2     Document Type: Article

References (22)

1. Recombinant calpain II: improved expression systems and production of a C105A active-site mutant for crystallography.
2. Calpain inhibition: an overview of its therapeutic potential.