Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment

Hepatology

Volumn 22, Issue 1, 1995, Pages 30-35

  Koizumi, Kazuhiko ^a   Enomoto, Nobuyuki ^a   Kurosaki, Masayuki ^a   Murakami, Takeshi ^a   Izumi, Namiki ^c   Marumo, Fumiaki ^a   Sato, Chifumi ^a,b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c MUSASHINO RED CROSS HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; VIRUS DNA;

ADULT; AGED; ARTICLE; BIODIVERSITY; CHRONIC ACTIVE HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENETIC VARIABILITY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MALE; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; VIRUS STRAIN;

AGED; BASE SEQUENCE; CHRONIC DISEASE; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMAN; INTERFERONS; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE PROBES; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SUPPORT, NON-U.S. GOV'T; TREATMENT OUTCOME;

EID: 0029163517     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1016/0270-9139(95)90349-6     Document Type: Article

References (37)

1. The hypervariable region of HCV genome changes sequentially with the progression of acute HCV infection to chronic hepatitis
2. Dynamics of genome change in the E2/NS1 region of hepatitis C virus in vivo
3. Sequence variation in the large envelope glycoprotein (E2/NS1) of hepatitis C virus during chronic infection
4. Rapid sequence variation of the hypervariable region of hepatitis C virus during the course of chronic infection
5. Nucleotide sequence and mutation rate of the H strain of hepatitis C virus
6. Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability
7. Sequential change of the hypervariable region of the hepatitis C virus genome in acute hepatitis
8. Adaptation of hepatitis C virus for persistent infection in patients with acute hepatitis
9. Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins
10. A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/ NS1 protein: implication for an escape from antibody
11. Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: humoral immune response to hypervariable region 1
12. Genetic alteration of the hepatitis C virus hypervariable region obtained from an asymptomatic carrier
13. Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus
14. The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients
15. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution
16. Treatment of chronic hepatitis C with recombinant interferon alfa: a multicenter randomized, controlled trial
17. Characterization of the 5′ noncoding and structural region of the hepatitis C virus genome from patients with non-A non-B hepatitis responding differently to interferon treatment
18. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
19. Exclusion of false-positive PCR viral diagnosis by single-strand conformation polymorphism
20. Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis
21. Classification of chronic hepatitis: diagnosis, grading and staging
22. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
23. Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-noncoding region
24. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources
25. A proposed system for the nomenclature of hepatitis C viral genotypes
26. Quantitative detection of hepatitis C virus RNA by multicyclic RT-PCR
27. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis
28. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
29. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
30. Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus
31. Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas
32. Nonisotopic SSCP detection in PCR products by ethidium bromide staining
33. Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant
34. RNA virus populations as quasispecies
35. Hepatitis C virus after interferon treatment has the variation in the hypervariable region of envelope 2 gene
36. Factors predictive of response to interferonalpha therapy in hepatitis C virus infection
37. Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C