Fas-mediated cytotoxicity: An immunoeffector or immunoregulatory pathway inT cell-mediated immune responses?

Transplantation

Volumn 60, Issue 3, 1995, Pages 221-224

  Larsen, Christian P ^a   Alexander, Diane Z ^a   Hendrix, Rose ^a   Ritchie, Shannon C ^a   Pearson, Thomas C ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; MEMBRANE ANTIGEN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EFFECTOR CELL; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOREGULATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTIBODY FORMATION; ANTIGENS, CD4; ANTIGENS, CD95; ANTIGENS, SURFACE; BASE SEQUENCE; CELL DEATH; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNITY, CELLULAR; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES;

EID: 0029161921     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199508000-00002     Document Type: Article

References (37)

1. Itoh N, Yonehara S, Ishii A, et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apop-tosis. Cell 1991; 66(2): 233.
2. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993; 75(6): 1169.
3. Russell HH, Rush B, Weaver C, Wang R. Mature T cells of autoimmune Ipr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci USA 1993; 90: 4409.
4. Smith CA, Williams GT, Kingston R, Jenkinson EJ, Owen JJT. Antibodies to CD3/T cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 1989; 337: 181.
5. +TCR° thymocytes in vivo. Science 1990; 250: 1720.
6. Webb S, Morris C, Sprent J. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 1990; 63: 1249.
7. Kawabe Y, Ochi A. Programmed cell death and extrathymic reduction of Vß8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 1991; 349: 245.
8. Webb SR, Hutchinson J, Hayden K, Sprent J. Expansion/dele tion of mature T cells exposed to endogenous superantigens in vivo. J Immunol 1994; 152: 586.
9. Surh CD, Sprent J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 1994; 372: 100.
10. Ju ST, Cui H, Panka DJ, Ettinger R, Marshak-Rothstein A. Participation of target Fas protein in apoptosis pathway induced by CD4+ Thl and CD8+ cytotoxic T cells. Proc Natl Acad Sci USA 1994; 91(10): 4185.
11. Hanabuchi S, Koyanagi M, Kawasaki A, et al. Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity. Proc Natl Acad Sci USA 1994; 91(11): 4930.
12. Kagi D, Vignaux F, Ledermann B, et al. Fas and perforin path ways as major mechanisms of T cell-mediated cytotoxicity. Science 1994; 265(5171): 528.
13. Stalder T, Hahn S, Erb P. Fas antigen is the megor target molecule for CD4+ T cell-mediated cytotoxicity. J Immunol 1994; 152(3): 1127.
14. Dallman MJ, Mason DW, Webb M. The roles of host and donor cells in the rejection of skin allografts by T cell-deprived rats injected with syngeneic T cells. Eur J Immunol 1982; 12: 511.
15. Bolton EM, Gracie JA, Briggs JD, Kampinga J, Bradley JA. Cellular requirements for renal allograft rejection in the athymic nude rat. J Exp Med 1989; 169: 1931.
16. Dallman MJ, Larsen CP, Morris PJ. Cytokine gene transcription in vascularized organ grafts: analysis using semi-quantitative polymerase chain reaction. J Exp Med 1991; 174: 493.
17. Cobbold S, Waldmann H. Skin allograft rejection by L3T4+ and LYT-2+ T cell subsets. Transplantation 1986; 41(5): 634.
18. Madsen JC, Wood KJ, Morris PJ. Effects of anti-L3T4 and anti-LYT-2 monoclonal antibodies on murine cardiac allograft rejection. Transplant Proc 1987; 19(5): 3991.
19. Gracie JA, Bolton EM, Porteous C, Bradley JA. T cell require ments for the rejection of renal allografts bearing an isolated class I MHC disparity. J Exp Med 1990; 172(6): 1547.
20. Sprent J, Surh CD, Agus D, Hurd M, Sutton S, Heath WR. Profound atrophy of the bone marrow reflecting mtyor histocompatibility complex class II-restricted destruction of stem cells by CD4+ cells. J Exp Med 1994; 180(1): 307.
21. Takeuchi T, Lowry R, Konieczny B. Heart allografts in murine systems: the differential activation of Th2-line effector cells in peripheral tolerance. Transplantation 1992; 53: 1281.
22. Hancock WH, Whitley WD, Tullius SG, et al. Cytokines, adhe sion molecules, and the pathogenesis of chronic rejection of rat renal allografts. Transplantation 1993; 56(3): 643.
23. Scott DE, Kibch WJ, Steinberg AD. Studies of T cell deletion and T cell energy following in vivo administration of SEB to normal and lupus-prone mice. J Immunol 1993; 150(2): 664.
24. Singer GG, Abbas AK. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994; 1: 365.
25. Mountz JD, Bluethmann H, Zhou T, Wu J. Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice. Semin Immunol 1994; 6: 27.
26. Corry RJ, Winn HJ, Russell PS. Primarily vascularized al lografts of hearts in mice: the role of H-2D, H-2K, and non-H-2 anitgens in rejection. Transplantation 1973; 16(4): 343.
27. Larsen CP, Ritchie SC, Hendrix R, et al. Regulation of immuno-stimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J Immunol 1994; 152(11): 5208.
28. Montgomery RA, Dallman MJ. Analysis of cytokine gene expres sion during fetal thymic ontogeny using the polymerase chain reaction. J Immunol 1991; 147: 554.
29. Watanabe-Fukunaga R, Brannan Cl, Itoh N, et al. The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol 1992; 148(4): 1274.
30. Takahashi T, Tanaka M, Brannan Cl, et al. Generalized lym-phoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994; 76(6): 969.
31. Nagata S. Mutations in the Fas antigen gene in lpr mice. Semin Immunol 1994; 6: 3.
32. Watanabe-Fukunaga R, Brannan Cl, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992; 356(6367): 314.
33. Lynch DH, Watson ML, Alderson MR, et al. The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1994; 1(2): 131.
34. Zijlstra M, Auchincloss H Jr, Loring JM, Chase CM, Russell PS, Jaenisch R. Skin graft rejection by beta 2-microglobulin-defi-cient mice. J Exp Med 1992; 175(4): 885.
35. Trauth BC, Klas C, Peters AM, et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 1989; 245(4915): 301.
36. Miyawaki T, Uehara T, Nibu R, et al. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol 1992; 149(11): 3753.
37. Owen-Schaub LB, Yonehara S, Crump WLd, Grimm EA. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell Immunol 1992; 140(1): 197.