Upregulation of connexin43 gap junctions during early stages of human coronary atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 15, Issue 8, 1995, Pages 1219-1228

  Blackburn, J P ^a   Peters, N S ^b   Yeh, H I ^a   Rothery, S ^a   Green, C R ^c   Severs, N J ^a,d  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

atheroma; connexin43; coronary artery; gap junctions; smooth muscle cell

Indexed keywords

CONNEXIN 43;

ARTICLE; ATHEROGENESIS; ATHEROMA; ATHEROSCLEROSIS; CELL JUNCTION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE;

EID: 0029161009     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.15.8.1219     Document Type: Article

References (62)

1. Wissler RW. Update on the pathogenesis of atherosclerosis. Am J Med. 1991;91(suppl 1B):3S-9S.
2. Wissler RW. Theories and new horizons in the pathogenesis of atherosclerosis and the mechanisms of clinical effects. Arch Pathol Lab Med. 1992;116:1281-1291.
3. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
4. Ross R. Atherosclerosis: current understanding of mechanisms and future strategies in therapy. Transplant Proc. 1993;25:2041-2043.
5. Campbell GR, Campbell JH, Manderson JA, Horrigan S, Rennick RE. Arterial smooth muscle: a multifunctional mesenchymal cell. Arch Pathol Lab Med. 1988;112:977-986.
6. Robenek H, Severs NJ. Cell Interactions in Atherosclerosis. Boca Raton, Fla: CRC Press; 1992:1-318.
7. Ross R. Atherosclerosis: a defense mechanism gone awry. Am J Pathol. 1993;143:987-1002.
8. De Mello WC. Cell Intercommunication. Boca Raton, Fla: CRC Press; 1990:1-290.
9. Dermietzel R, Hwang TK, Spray DS. The gap junction family: structure, function and chemistry. Anat Embiyol. 1990;182:517-528.
10. Bennett MVL, Barrio LC, Bargiello TA, Spray DC, Hertzberg E, Sáez JC. Gap junctions: new tools, new answers, new questions. Neuron. 1991;6:305-320.
11. Willecke K, Hennemann H, Dahl E, Jungbluth S, Heynkes R. The diversity of connexin genes encoding gap-junctional proteins. Eur J Cell Biol. 1991;56:1-7.
12. Peracchia C. Biophysics of Gap Junction Channels. Boca Raton, Fla: CRC Press; 1991:1-384.
13. Hall JE, Zampighi GA, Davis RM. Progress in Cell Research. Vol 3: Gap Junctions. New York, NY: Elsevier Science Publishers; 1993: 1-356.
14. Beyer EC. Gap junctions. Int Rev Cytol. 1993;137C:1-37.
15. Beyer EC, Paul DL, Goodenough DA. Connexin family of gap junction proteins. J Membr Biol. 1990;116:187-194.
16. Kumar NM. Gap junctions: a multigene family. Adv Struct Biol. 1992;1:209-249.
17. Page E. Cardiac gap junctions. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE, eds. The Heart and Cardiovascular System. New York, NY: Raven Press Ltd; 1992:1003-1048.
18. Loewenstein WR. Junctional intercellular communication and the control of growth. Biochim Biophys Acta. 1979;560:1-65.
19. Mehta P, Bertram J, Loewenstein WR. Growth inhibition of transformed cells correlates with junctional communication with normal cells. Cell. 1986;44:187-196.
20. Fraser SE, Green CR, Bode HR, Gilula NB. Selective disruption of gap junctional communication interferes with a patterning process in Hydra. Science. 1987;237:49-55.
21. Warner AE, Guthrie SC, Gilula NB. Antibodies to gap-junctional protein selectively disrupt junctional communication in early embryos. Nature. 1984;322:127-131.
22. Loewenstein WR, Rose B. The cell-cell channel in the control of growth. Semin Cell Biol. 1992;3:59-79.
23. Navab M, Ross LA, Hama S, Liao F, Hough GP, Drinkwater DC, Laks H, Fogelman AM. Interactions of human aortic wall cells in co-culture. Atheroscler Rev. 1991;23:153-160.
24. Polacek D, Lal R, Volin MV, Davies PF. Gap junctional communication between vascular cells: induction of connexin43 messenger RNA in macrophage foam cells of atherosclerotic lesions. Am J Pathol. 1993;142:593-606.
25. Katsuda S, Boyd HC, Fligner C, Ross R, Gown AM. Human atherosclerosis, III: immunocytochemical analysis of the cell composition of lesions of young adults. Am J Pathol. 1992;140:907-914.
26. Katsuda S, Coltrera MD, Ross R, Gown AM. Human atherosclerosis, IV: immunocytochemical analysis of cell activation and proliferation in lesions of young adults. Am J Pathol. 1993;142: 1787-1793.
27. Lash JA, Critser ES, Pressler ML. Cloning of a gap junctional protein from vascular smooth muscle and expression in two-cell mouse embryos. J Biol Chem. 1990;265:13113-13117.
28. Rennick RE, Connat J-L, Burnstock G, Rothery S, Severs NJ, Green CR. Expression of connexin43 gap junctions between cultured vascular smooth muscle cells is dependent upon phenotype. Cell Tissue Res. 1993;271:323-332.
29. Harfst E, Severs NJ, Green CR. Cardiac myocyte gap junctions: evidence for a major connexon protein with an apparent relative molecular mass of 70,000. J Cell Sci. 1990;96:591-604.
30. Gourdie RG, Green CR, Severs NJ. Gap junction distribution in adult mammalian myocardium revealed by an antipeptide antibody and laser scanning confocal microscopy. J Cell Sci. 1991;99:41-55.
31. Toshimori H, Toshimori K, Oura C, Matsuo H. Immunohistochemistry and immunocytochemistry of natriuretic polypeptide in porcine heart. Histochemistry. 1987;86:595-601.
32. Severs NJ, Slade AM, Powell T, Twist VW, Jones GE. Morphometric analysis of the isolated calcium-tolerant cardiac myocyte: organelle volumes, sarcomere length, plasma membrane surface folds and intramembrane particle density and distribution. Cell Tissue Res. 1985;240:159-168.
33. Beyer EC, Paul DL, Goodenough DA. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol. 1987;105:2621-2629.
34. Green CR, Severs NJ. Distribution and role of gap junctions in normal myocardium and human ischaemic heart disease. Histochemistry. 1993;99:105-120.
35. Severs NJ, Gourdie RG, Harfst E, Peters NS, Green CR. Intercellular junctions and the application of microscopical techniques: the cardiac gap junction as a case model. J Microsc. 1993;169: 299-328. Review.
36. Gourdie RG, Harfst E, Severs NJ, Green CR. Cardiac gap junctions in rat ventricle: localization using site-directed antibodies and laser scanning confocal microscopy. Cardioscience. 1990;1: 75-82.
37. Harlow E, Lane D. Antibodies: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Press; 1988:1-726.
38. Green CR, Peters NS, Gourdie RG, Rothery S, Severs NJ. Validation of immunohistochemical quantification in confocal scanning laser microscopy: a comparative assessment of gap junction size with confocal and ultrastructural techniques. J Histochem Cytochem. 1993; 41:1339-1349.
39. World Health Organization. Classification of atherosclerotic lesions: report of a study group. WHO Tech Rep Ser. 1958;143:1-20.
40. Guzmán MA, McMahan CA, McGill HC Jr, Strong JP, Tejada C, Restrepo C, Eggan DA, Robertson WB, Solberg LA. Selected methodologic aspects of the international atherosclerosis project. Lab Invest. 1968;18:479-497.
41. Stary H. Evolutional progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis. 1989; 9(suppl 1):19-32.
42. Stary HC, Bleakley Chandler A, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association, Arterioscler Thromb. 1994;14:840-856.
43. Stary HC, Chandler AB, Glagov S, Guyton JR, Insull W Jr, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1994;89:2462-2478.
44. Stary HC, Blankenhorn DH, Chandler AB, Glagov S, Insull W Jr, Richardson M, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW. Special report: a definition of the intima of human arteries and of its atherosclerosis-prone regions: a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1992;85: 391-405.
45. Kocher O, Gabbiani F, Gabbiani G, Reidy MA, Cokay MS, Peters H, Hüttner I. Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening: biochemical and morphologic studies. Lab Invest. 1991;65:459-470.
46. Vankova M, Grünwald J. Gap junctional vesicles in the neointimal smooth muscle cells of balloon injured carotid artery. Exp Pathol. 1991;42:101-105.
47. Larson DM, Haudenschild CC, Beyer EC. Gap junction messenger RNA expression by vascular wall cells. Circ Res. 1990;66:1074-1080.
48. Moore LK, Beyer EC, Burt JM. Characterization of gap junction channels in A7r5 vascular smooth muscle cells. Am J Physiol. 1991; 260(Cell Physiol):C975-C981.
49. Bruzzone R, Haefliger J-A, Gimlich RL, Paul DL. Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins. Mol Biol Cell. 1993;4: 7-19.
50. 1 adrenergic agonist efficacy in isolated rat aorta. J Pharmacol Exp Ther. 1993;266:1054-1065.
51. Bény J-L, Connat J-L. An electron-microscopic study of smooth muscle cell dye coupling in the pig coronary arteries: role of gap junctions. Circ Res. 1992;70:49-55.
52. Beyer EC, Reed KE, Westphale EM, Kanter HL, Larson DM. Molecular cloning and expression of rat connexin40, a gap junction protein expressed in vascular smooth muscle. J Membr Biol. 1992; 127:69-76.
53. Little TL, Beyer EC, Duling BR. Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vivo. Am J Physiol. 1995;268(Heart Circ Physiol): H729-H739.
54. Bastide B, Neyses L, Ganten D, Paul M, Willecke K, Traub O. Gap junction protein connexin40 is preferentially expressed in vascular endothelium and conductive bundles of rat myocardium and is increased under hypertensive conditions. Circ Res. 1993;73:1138-1149.
55. Reed KE, Westphale EM, Larson DM, Wang H-Z, Veenstra RD, Beyer EC. Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J Clin Invest. 1993;91:997-1004.
56. Pepper MS, Montesano R, El Aoumari A, Gros D, Orci L, Meda P. Coupling and connexin 43 expression in microvascular and large vessel endothelial cells. Am J Physiol. 1992;262(Cell Physiol): C1246-C1257.
57. Beyer EC, Steinberg TH. Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages. J Biol Chem. 1991;266:7971-7974.
58. Yamamoto T, Kardami E, Nagy JI. Basic fibroblast growth factor in rat brain: localization to glial gap junctions correlates with connexin43 distribution. Brain Res. 1991;554:336-343.
59. Kardami E, Stoski RM, Doble BW, Yamamoto T, Hertzberg EL, Nagy JI. Biochemical and ultrastructural evidence for the association of basic fibroblast growth factor with cardiac gap junctions. J Biol Chem. 1991;266:19551-19557.
60. Doble BW, Kardami E. Basic fibroblast growth factor stimulates connexin-43 expression and intercellular communication of cardiac fibroblasts. Mol Cell Biochem. 1995;143:81-87.
61. Meyer RA, Lampe PD, Malewicz B, Baumann WJ, Johnson RG. Enhanced gap junction formation with LDL and apolipoprotein B. Exp Cell Res. 1991;196:72-81.
62. Campbell GR, Campbell JH. Recent advances in molecular pathology: smooth muscle phenotypic changes in arterial wall homeostasis: implications for the pathogenesis of atherosclerosis. Exp Mol Pathol. 1985;42:139-162.