Transmission of fatal familial insomnia to laboratory animals

The Lancet

Volumn 346, Issue 8974, 1995, Pages 569-570

  Collinge, John ^a,b,c,d   Palmer, MarkS ^b,c,d   Sidle, KatieC L ^b,c,d   Gowland, Ian ^b,c,d   Medori, Rosella ^b,c,d   Ironside, James ^b,c,d   Lantos, Peter ^b,c,d  

^a Prion Disease Group Department of Biochemistry and Molecular Genetics St Mayr's Hospital Medical School ^*  (United Kingdom)

^b

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN SPONGIOSIS; CREUTZFELDT JAKOB DISEASE; DISEASE CLASSIFICATION; DISEASE TRANSMISSION; GENE MUTATION; GENOTYPE; HISTOLOGY; IMMUNOBLOTTING; LETTER; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0029160006     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(95)91405-6     Document Type: Letter

References (5)

1. Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease
2. Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
3. Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein
4. First experimental transmission of fatal familial insomnia
5. A PrP gene codon 178 base substitution and a 24-bp interstitial deletion in familial Creutzfeldt-Jakob disease