Cooperativity between Non-polar and Ionic Forces in the Binding of Bacterial Cell Wall Analogues by Vancomycin in Aqueous Solution

The Journal of Antibiotics

Volumn 48, Issue 8, 1995, Pages 805-810

  Cristofaro, Michael F ^a   Beauregard, Daniel A ^a   Yan, Husheng ^a   Osborn, Nigel J ^a   Williams, Dudley H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VANCOMYCIN; VANCOMYCIN DERIVATIVE;

ARTICLE; BACTERIAL CELL WALL; CELL DEATH; CHEMICAL BINDING; CHEMICAL BOND; DRUG BINDING; GRAM POSITIVE BACTERIUM; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY;

AMINO ACID SEQUENCE; BACTERIA; BINDING SITES; CELL WALL; COMPARATIVE STUDY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; VANCOMYCIN;

EID: 0029159990     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.48.805     Document Type: Article

References (12)

1. Nieto, M. & H. R. Perkins: Modifications of the acyl-D-alanyl-D-alanine terminus affecting complex-formation with vancomycin. Biochem. J. 123: 789 —903, 1971
2. Williams, D. H. & J. P. Waltho: The molecular basis of the activity of antibiotics of the vancomycin group. Biochem. Pharm. 37: 133 —141, 1988
3. Waltho, J. P.; J. Cavanagh & D. H. Williams: Aspects of molecular recognition: Use of a truncated driven pseudo-NOESY experiment to elucidate the environment of intermolecular electrostatic interactions in vancomycin. J. Chem. Soc., Chem. Commun. 1988: 707–709, 1988
4. Kannan, R.; C. M. Harris, T. M. Harris, J. P. Waltho, N. J. Skelton & D. H. Williams: Function of the amino sugar and N-terminal amino acid of the antibiotic vancomycin in its complexation with cell wall peptides. J. Am. Chem. Soc. 110: 2946–2953, 1988
5. Waltho, J. P.; D. H. Williams, D. J. M. Stone & N. J. Skelton: Intramolecular determinants of conformation and mobility within the antibiotic vancomycin. J. Am. Chem. Soc. 110: 5638–5643, 1988
6. Convert, O.; A. Bongini& J. Feeney:A 1H nuclear magnetic resonance study of the interactions of vancomycin with N-acetyl-D-alanyl-D-alanine and related peptides. J. Chem. Soc., Perkin Trans. II 1980: 1262 — 1270, 1980
7. Booth, P. M. & D. H. Williams: Preparation and conformational analysis of vancomycin hexapeptide and aglucovancomycin hexapeptide. J. Chem. Soc., Perkin Trans. I 1989: 2335–2339, 1989
8. Williams, D.H.; J. P. L. Cox, A. J. Doig, M. Gardner, U. Gerhard, P. T. Kaye, A. R. Lal, I. A. Nicholls, C. J. Salter & R. C. J. Mitchell: Toward the semiquantitative estimation of binding constants. Guides for peptide-peptide binding in aqueous solution. J. Am. Chem. Soc. 113: 7020–7030, 1991
9. Searle, M. S.; D. H. Williams & U. Gerhard: Partitioning of free energy contributions in the estimation of binding constants: residual motions and consequences for amide-amide hydrogen bond strengths. J. Am. Chem. Soc. 114: 10697–10704, 1992
10. Serrano, L.; J.-L. Neira, J. Sancho &A. R. Fersht: Effect of alanine versus glycine in a-helix protein stability. Nature 356: 453–455, 1992
11. See, for example, Atkins, P. W.: Physical Chemistry. Oxford University Press, 1978, pp. 316 — 317.
12. Kannan, R.; C. M. Harris, T. M. Harris, J. P. Waltho, N. J. Skelton& D. H. Williams: Function of the amino sugar and N-terminal amino acid of the antibiotic vancomycin in its complexation with cell wall peptides. J. Am. Chem. Soc. 110: 2946–2953, 1988