Mutant and native human β-amyloid precursor proteins in transgenic mouse brain

Neurobiology of Aging

Volumn 16, Issue 4, 1995, Pages 685-699

  Howland, David S ^a   Savage, Mary J ^a   Huntress, Frederick A ^b   Wallace, Racheal E ^b   Schwartz, Daniel A ^a   Loh, Tatjana ^a   Melloni Jr , Richard H ^c   Degennaro, Louis J ^c   Greenberg, Barry D ^a   Siman, Robert ^a   Swanson, Mark E ^b   Scott, Richard W ^a  

^a CEPHALON INC   (United States)

^b DNX Corporation   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Alzheimer's disease; Synapsin I promoter; Transgenic mice; amyloid precursor protein

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MUTANT PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; GENE EXPRESSION; MOLECULAR CLONING; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMAL; BRAIN; FEMALE; HUMAN; IMMUNOBLOTTING; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; MUTATION; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); RNA; SYNAPSINS;

EID: 0029159875     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(95)00078-S     Document Type: Article

References (71)

1. Immunochemical identification of the serine protease inhibitor alpha- l-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
2. Differential brain expression of the Alzheimer's amyloid precursor protein
3. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding
4. Binding of the vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide
5. Expression o f APP in brains of transgenic mice containing the entire human APP gene
6. Release of excess amyloid β protein from a mutant amyloid β protein precursor
7. Early onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
8. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
9. Excessive production of amyloid β-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation
10. Molecular genetics of Alzheimer's disease
11. Small cerebral hemispheres in adults with Down's syndrome: Contributions of developmental arrest and lesions of Alzheimer's disease
12. The amyloid β protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported
13. Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease
14. Comparative analysis of human and Dutch-type Alzheimer β-amyloid peptides by infrared spectroscopy and cellular dichroism
15. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
16. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
17. Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue
18. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
19. Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
20. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β-amyloid precursor protein gene
21. Higgins, L.S.; Catalano, R.; Quon, D.; Cordell, B. Transgenic mice expressing human β-APP751, but not mice expressing β-APP695, display early Alzheimer's disease-like histopathology. Ann. NY. Acad. Sci. 695:224–227.
22. Transgenic mouse brain histopathology resembles early Alzheimer's disease
23. Site-directed mutagenesis by overlap extension using the polymerase chain reaction
24. The 5′ flanking region of the rat synapsin I gene directs neuron-specific and developmentally regulated reporter gene expression in transgenic mice
25. Positive- and negative-acting promoter sequences regulate cell-type specific expression of the rat synapsin I gene
26. Seeding “One-dimensional crystallization” of amyloid; A pathogenic mechanism in Alzheimer's disease and Scrapie?
27. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell surface receptor
28. Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β-amyloid precursor protein gene
29. Detection and quantitation of amyloid β-peptide with 2 monoclonal antibodies
30. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
31. Cleavage of structural proteins during assembly of the head of bacteriophage T4
32. Introduction and expression of the 400 kilobase precursor amyloid protein gene in transgenic mice
33. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
34. In situ hybridization histochemistry with radioactive and nonradioactive cRNA and DNA probes
35. Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene
36. The pathologic association between Down Syndrome and Alzheimer disease
37. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's Syndrome and Alzheimer's disease
38. Amyloid plaque core protein in Alzheimer disease and Down syndrome
39. Synapsin I gene expression in the adult rat brain with comparative analysis of mRNA and protein in hippocampus
40. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid
41. High affinity interactions between the Alzheimer's β-amyloid precursor proteins and the basement mem brane form of heparan sulfate proteoglycan
42. Mis-sense mutation Val-Ile in exon 17 of the amyloid precursor protein gene in Japanese familial Alzheimer's disease
43. The Alzheimer amyloid precursor protein
44. Expression of the human β-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice
45. A new A4 amyloid mRNA contains a domain homologous to serine protease inhibitors
46. The involvement of proteases, protease inhibitors, and acute phase response in Alzheimer's disease
47. Alzheimer disease and the prion disorders amyloid β-protein and prion protein amyloidoses
48. Formation of β-amyloid deposits in brains of transgenic mice
49. Structural alterations in the peptide backbone of β-amyloid core protein may account for its deposition and stability in Alzheimer's disease
50. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease
51. The 5′ flanking region of the synapsin I gene
52. Localization in human cerebral cortex and generation of amyloidogenic fragments from the β-amyloid precursor protein
53. Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease
54. Production of the Alzheimer amyloid β protein by normal proteolytic processing
55. Processing of the β-amyloid precursor. Multiple proteases generate and degrade potentially amyloidogenic fragments
56. An important role of heparan sulfate proteoglycan (perlecan) in a model sys tem for the deposition and persistence of fibrillary Aβ-amyloid in rat brain
57. Apolipoprotein E: High avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease
58. Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease
59. An increased percentage of long amyloid R protein secreted by familial amyloid R protein precursor (βAPP717) mutants
60. Characterization of tissuespecific transcription by the human synapsin I gene promoter
61. Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease
62. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
63. Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
64. Apolipoprotein E: A pathologic chaperone protein in patients with cerebral and systemic amyloid
65. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
66. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
67. Structure and expression of the alternatively spliced forms of mRNA for the mouse homolog of Alzheimer disease amyloid beta protein precursor
68. Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory