3′-Azidothymidine (Zidovudine) inhibits glycosylation and dramatically alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations

Journal of Biological Chemistry

Volumn 270, Issue 39, 1995, Pages 22836-22841

  Yan, Jian Ping ^a   Ilsley, Diane D ^a   Frohlick, Corinne ^a   Steet, Richard ^a   Hall, Edina T ^a   Kuchta, Robert D ^a   Melançon, Paul ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSPHINGOLIPID; ZIDOVUDINE;

ARTICLE; CELL STRAIN K 562; DNA SYNTHESIS INHIBITION; DRUG EFFECT; HUMAN; HUMAN CELL; LIPID ANALYSIS; LIPOGENESIS; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION;

CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; CELL LINE; COMPARATIVE STUDY; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GALACTOSE; GLYCOSPHINGOLIPIDS; GLYCOSYLATION; GOLGI APPARATUS; HEXOSAMINES; HUMAN; KINETICS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MOLECULAR SEQUENCE DATA; RADIOISOTOPE DILUTION TECHNIQUE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRITIUM; TUMOR CELLS, CULTURED; ZIDOVUDINE;

EID: 0029157098     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.270.39.22836     Document Type: Article

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