Thymidylate synthase and drug resistance

European Journal of Cancer

Volumn 31, Issue 7-8, 1995, Pages 1299-1305

  Peters, G J ^a   van der Wilt, C L ^a   van Triest, B ^a   Codacci Pisanelli, G ^a   Johnston, P G ^b   van Groeningen, C J ^a   Pinedo, H M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

5 fluorouracil; antifolates; folates; leucovorin; resistance; thymidylate synthase

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; FOLINIC ACID; THYMIDYLATE SYNTHASE;

DRUG RESISTANCE; ENZYME INHIBITION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMAL; ANTIMETABOLITES, ANTINEOPLASTIC; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; HUMAN; MICE; PROGNOSIS; SUPPORT, NON-U.S. GOV'T; THYMIDYLATE SYNTHASE; TUMOR MARKERS, BIOLOGICAL;

EID: 0029156922     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(95)00172-F     Document Type: Article

References (42)

1. 5-Fluorouracil: biochemistry and pharmacology
2. Resistance to antimetabolites
3. Thymidylate synthase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil
4. Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
5. Thymidylate synthase inhibition after administration of 5-fluorouracil with or without leucovorin; implications for treatment with 5-fluorouracil
6. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil
7. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
8. Development, characterization and application of an antibody against 5-fluoro-2′deoxy-5′-monophosphate, the active metabolite of 5-fluorouracil
9. Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells
10. Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil
11. Relationship of dUMP and FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil
12. A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2′-deoxyuridine in a human colon tumor cell line
13. Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma
14. Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors
15. Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?
16. Binding of 5-fluorodeoxyuridylate to thymidylate synthase in human colon adenocarcinoma xenografts
17. Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance
18. Clinical relevance of biochemical modulation of 5-fluorouracil
19. Effect of folate diastereoisomers on the binding of 5-fluoro-2′-deoxyuridine5-́monophosphate to thymidylate synthase
20. Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines
21. Thymidylate synthase overproduction gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy
22. Enhancement of the antitumor effects of 5-fluorouracil by folinic acid
23. Schedule dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma
24. In vivo kinetics of thymidylate synthetase inhibition in FUrasensitive and -resistant murine colon adenocarcinomas
25. Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice
26. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase
27. Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma
28. Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2′-deoxyuridine-5′-monophosphate
29. Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent
30. Measurement of human thymidylate synthase (hTS) in cell lines using ELISA
31. Quantitation of thymidylate synthase in human tumors using an ultrasensitive enzyme-linked immunoassay
32. Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue
33. Evaluation of immunohistochemical staining and activity of thymidylate synthase in cell lines
34. Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
35. Polymerase chain reaction quantification of thymidylate synthase (TS) mRNA levels in tumour samples of patients recently treated with 5-fluorouracil (5-FU) ± leucovorin (LV)
36. A role for dihydropyrimid- ine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil
37. Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase
38. Thymidylate synthase levels in patients with colorectal cancer
39. Thymidylate synthase (TS) gene expression predicts response of primary gastric cancer (GC) to 5-fluorouracil (5FU)-leucovorin (LV)-cisplatin (DDP)
40. Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial
41. ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer