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Volumn 269, Issue 5229, 1995, Pages 1427-1429

Inducible gene targeting in mice

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; INTERFERON; RECOMBINASE;

EID: 0029155706     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.7660125     Document Type: Article
Times cited : (1561)

References (30)
  • 2
    • 0028500365 scopus 로고
    • B. H. Koller and O. Smithies, Annu. Rev. Immunol. 10, 705 (1992); D. W. Melton, Bioessays 16, 633 (1994).
    • (1994) Bioessays , vol.16 , pp. 633
    • Melton, D.W.1
  • 4
    • 0019888362 scopus 로고
    • N. Sternberg and D. Hamilton, J. Mol. Biol. 150, 467 (1981); B. Sauer and N. Henderson, Proc. Natl. Acad. Sci. U.S.A. 85, 5166 (1988).
    • (1981) J. Mol. Biol. , vol.150 , pp. 467
    • Sternberg, N.1    Hamilton, D.2
  • 9
    • 0023009702 scopus 로고
    • P. Staeheli, P. Danielson, O. Haller, G. Sutcliffe, Mol. Cell. Biol. 6, 4770 (1986); G. C. Sen and R. M. Ransohoff, Adv. Virus Res. 42, 57 (1993); B. R. G. Williams, Eur. J. Biochem. 200, 1 (1991); K.-C. Chang, G. Goldspink, J. Lida, Arch. Virol. 110, 151 (1990).
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 4770
    • Staeheli, P.1    Danielson, P.2    Haller, O.3    Sutcliffe, G.4
  • 10
    • 0027352378 scopus 로고
    • P. Staeheli, P. Danielson, O. Haller, G. Sutcliffe, Mol. Cell. Biol. 6, 4770 (1986); G. C. Sen and R. M. Ransohoff, Adv. Virus Res. 42, 57 (1993); B. R. G. Williams, Eur. J. Biochem. 200, 1 (1991); K.-C. Chang, G. Goldspink, J. Lida, Arch. Virol. 110, 151 (1990).
    • (1993) Adv. Virus Res. , vol.42 , pp. 57
    • Sen, G.C.1    Ransohoff, R.M.2
  • 11
    • 0025797722 scopus 로고
    • P. Staeheli, P. Danielson, O. Haller, G. Sutcliffe, Mol. Cell. Biol. 6, 4770 (1986); G. C. Sen and R. M. Ransohoff, Adv. Virus Res. 42, 57 (1993); B. R. G. Williams, Eur. J. Biochem. 200, 1 (1991); K.-C. Chang, G. Goldspink, J. Lida, Arch. Virol. 110, 151 (1990).
    • (1991) Eur. J. Biochem. , vol.200 , pp. 1
    • Williams, B.R.G.1
  • 12
    • 0025318556 scopus 로고
    • P. Staeheli, P. Danielson, O. Haller, G. Sutcliffe, Mol. Cell. Biol. 6, 4770 (1986); G. C. Sen and R. M. Ransohoff, Adv. Virus Res. 42, 57 (1993); B. R. G. Williams, Eur. J. Biochem. 200, 1 (1991); K.-C. Chang, G. Goldspink, J. Lida, Arch. Virol. 110, 151 (1990).
    • (1990) Arch. Virol. , vol.110 , pp. 151
    • Chang, K.-C.1    Goldspink, G.2    Lida, J.3
  • 13
    • 0018881591 scopus 로고
    • E. de Clerq, Antibiot. Chemother. (Basel) 27, 251 (1980); I. Gresser, Cell. Immunol. 34, 406 (1977); F. D. Finkelman et al., J. Exp. Med. 174, 1179 (1991).
    • (1980) Antibiot. Chemother. (Basel) , vol.27 , pp. 251
    • De Clerq, E.1
  • 14
    • 0017644453 scopus 로고
    • E. de Clerq, Antibiot. Chemother. (Basel) 27, 251 (1980); I. Gresser, Cell. Immunol. 34, 406 (1977); F. D. Finkelman et al., J. Exp. Med. 174, 1179 (1991).
    • (1977) Cell. Immunol. , vol.34 , pp. 406
    • Gresser, I.1
  • 15
    • 0025947127 scopus 로고
    • E. de Clerq, Antibiot. Chemother. (Basel) 27, 251 (1980); I. Gresser, Cell. Immunol. 34, 406 (1977); F. D. Finkelman et al., J. Exp. Med. 174, 1179 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 1179
    • Finkelman, F.D.1
  • 16
    • 0027280936 scopus 로고
    • flox allele to test for Cre-mediated deletion in vivo. Strains Mx-cre31 a and 31 b, which contain -10 transgene copies and originate from the same founder mouse but are distinguished by their transgene integration pattern, showed the most extensive deletion.
    • (1993) Cell , vol.73 , pp. 1155
    • Gu, H.1    Zou, Y.R.2    Rajewsky, K.3
  • 17
    • 0025119207 scopus 로고
    • flox allele to test for Cre-mediated deletion in vivo. Strains Mx-cre31 a and 31 b, which contain -10 transgene copies and originate from the same founder mouse but are distinguished by their transgene integration pattern, showed the most extensive deletion.
    • (1990) EMBO J. , vol.9 , pp. 3821
    • Chaffin, K.E.1
  • 18
    • 85035153749 scopus 로고    scopus 로고
    • note
    • The extent of deletion was comparable in purified B cells, T cells, and non-B-non-T cells (11).
  • 19
    • 85035154585 scopus 로고    scopus 로고
    • unpublished data
    • These results were reproducible in several independent experiments (R. Kühn, unpublished data).
    • Kühn, R.1
  • 20
    • 85035154447 scopus 로고    scopus 로고
    • unpublished data
    • R. Kühn, unpublished data.
    • Kühn, R.1
  • 22
    • 85035154772 scopus 로고    scopus 로고
    • unpublished data
    • J. Löhler, unpublished data.
    • Löhler, J.1
  • 23
    • 85035153499 scopus 로고    scopus 로고
    • unpublished data
    • Stainings were performed with antibodies to B220, immunoglobulin M, CD3, CD4, and CD8 (R. Kühn, unpublished data).
    • Kühn, R.1
  • 26
    • 0027179827 scopus 로고
    • R. K. Singhal and S. H. Wilson, J. Biol. Chem. 268, 15906 (1993); T. S.-F. Wang, Annu. Rev. Biochem. 60, 513 (1991); K. Wiebauer and J. Jiricny, Proc. Natl. Acad. Sci. U.S.A. 87, 5842 (1990).
    • (1993) J. Biol. Chem. , vol.268 , pp. 15906
    • Singhal, R.K.1    Wilson, S.H.2
  • 27
    • 0025826051 scopus 로고
    • R. K. Singhal and S. H. Wilson, J. Biol. Chem. 268, 15906 (1993); T. S.-F. Wang, Annu. Rev. Biochem. 60, 513 (1991); K. Wiebauer and J. Jiricny, Proc. Natl. Acad. Sci. U.S.A. 87, 5842 (1990).
    • (1991) Annu. Rev. Biochem. , vol.60 , pp. 513
    • Wang, T.S.-F.1
  • 28
    • 0025314841 scopus 로고
    • R. K. Singhal and S. H. Wilson, J. Biol. Chem. 268, 15906 (1993); T. S.-F. Wang, Annu. Rev. Biochem. 60, 513 (1991); K. Wiebauer and J. Jiricny, Proc. Natl. Acad. Sci. U.S.A. 87, 5842 (1990).
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 5842
    • Wiebauer, K.1    Jiricny, J.2
  • 29
    • 0028070714 scopus 로고
    • U. Müller et al., Science 264, 1918 (1994).
    • (1994) Science , vol.264 , pp. 1918
    • Müller, U.1
  • 30
    • 85035155431 scopus 로고    scopus 로고
    • note
    • We thank J. Löhler for the histological analysis, H. Gu forpo/β gene-targeted mice, C. Weissmann for IFN, and U. Ringeisen for graphical work. Supported by Deutsche Forschungsgemeinschaft grant SFB 243, the Human Frontier Science Program, the Bundesministerium für Forschung und Technologie, and the Land Nordrhein-Westfalen. F.S. is supported by a stipend from the Boehringer Ingelheim Fonds.


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