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The extent of deletion was comparable in purified B cells, T cells, and non-B-non-T cells (11).
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unpublished data
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These results were reproducible in several independent experiments (R. Kühn, unpublished data).
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Stainings were performed with antibodies to B220, immunoglobulin M, CD3, CD4, and CD8 (R. Kühn, unpublished data).
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We thank J. Löhler for the histological analysis, H. Gu forpo/β gene-targeted mice, C. Weissmann for IFN, and U. Ringeisen for graphical work. Supported by Deutsche Forschungsgemeinschaft grant SFB 243, the Human Frontier Science Program, the Bundesministerium für Forschung und Technologie, and the Land Nordrhein-Westfalen. F.S. is supported by a stipend from the Boehringer Ingelheim Fonds.
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