CD34+ progenitor cells from asymptomatic patients are not a major reservoir for human immunodeficiency virus-1

Blood

Volumn 86, Issue 5, 1995, Pages 1749-1756

  Neal, Thomas F ^b   Holland, H Kent ^b   Baum, Charles M ^b   Villinger, Francois ^b   Ansari, Aftab A ^b   Saral, Rein ^b   Wingard, John R ^b   Fleming, William H ^a  

^a EMORY UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; GAG PROTEIN; POL PROTEIN; VIRUS DNA;

ARTICLE; BONE MARROW CELL; BURST FORMING UNIT E; COLONY FORMING UNIT GM; CONTROLLED STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS CELL INTERACTION; VIRUS DETECTION;

EID: 0029154314     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v86.5.1749.bloodjournal8651749     Document Type: Article

References (37)

1. Zon L, Arkin C, Groopman J: Haematologic manifestations of the human immune deficiency virus (HIV). Br J Haematol 66:251, 1987
2. Spivak J, Bender B, Quinn T: Hematologic abnormalities in the acquired immune deficiency syndrome. Am J Med 77:224, 1984
3. Scadden D, Zon L, Groopman J: Pathophysiology and management of HIV-associated hematologic disorders. Blood 74:1455, 1989
4. Steinberg H, Crumpacker C, Chads P: In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus. J Virol 65:1765, 1991
5. + bone marrow cells are infected with HIV in a subset of seropositive individuals. J Immunol 149:417, 1992
6. Scadden D, Zeira M, Woon A, Wang Z, Schieve L, Ikeuchi K, Lim B, Groopman J: Human immunodeficiency virus infection of human bone marrow stromal fibroblasts. Blood 76:317, 1990
7. Calenda V, Graber P, Delamarter J, Chermann J: Involvement of HIV nef protein in abnormal hematopoiesis in AIDS: In vitro study on bone marrow progenitor cells. Eur J Haematol 52:103, 1994
8. Zauli G, Vitale M, Re M, Furlini G, Zamai L, Falcieri E, Gibellini D, Visani G, Davis B, Capitani S, La Placa M: In vitro exposure to human immunodeficiency virus type 1 induces apoptotic cell death of the factor dependent TF-1 cell line. Blood 83:167, 1994
9. Zauli G, Davis B, Re M, Visani G, Furlini G, La Placa M: Tat protein stimulates production of transforming growth factor-beta 1 by marrow macrophages: A potential mechanism for human immunodeficiency virus-1-induced hematopoietic suppression. Blood 80:3036, 1992
10. Leiderman I, Greenberg M, Adelsberg B, Siegal F: A glycoprotein inhibitor of in vitro granulopoiesis associated with AIDS. Blood 70:1267, 1987
11. Balleari E, Timitilli S, Puppo F, Gaffuri L, Musselli C, Rizzo F, Indiveri F, Ghio R: Impaired in vitro growth of peripheral blood hematopoietic progenitor cells in HIV infected patients: Evidence of an inhibitory effect of autologous T lymphocytes. Ann Hematol 63:320, 1991
12. Stella C, Ganser A, Hoelzer D: Defective in vitro growth of the hemopoietic progenitor cells in the acquired immunodeficiency syndrome. J Clin Invest 80:286, 1987
13. + hematopoietic progenitor cells are not a major reservoir of the human immunodeficiency virus. Blood 76:1281, 1990
14. Davis B, Schwartz D, Marx J, Johnson C, Berry J, Lyding J, Merigan T, Zander A: Absent or rare human immunodeficiency virus infection of bone marrow stem/progenitor cells in vivo. J Virol 65:1985, 1991
15. + progenitor cells are not infected by HIV-1 in vivo but show impaired clonogenesis. Br J Haematol 85:20, 1993
16. Folks T, Kessler S, Orenstein J, Justement J, Jaffe E, Fauci A: Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow. Science 242:919, 1988
17. Kitano K, Abboud C, Ryan D, Quan S, Baldwin G, Golde D: Macrophage-active colony-stimulating factors enhance human immunodeficiency virus type 1 infection in bone marrow stem cells. Blood 77:1699, 1991
18. Louache F, Debili N, Maradin A, Coulombel L, Vainchenker W: Expression of CD4 by human hematopoietic progenitors. Blood 84:3344, 1994
19. Baum C, Weissman I, Tsukamoto A, Buckle A, Peault B: Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA 89:2804, 1992
20. Ou C, Kwok S, Mitchell S, Mack D, Sninsky J, Krebs J, Deorino P, Wardield D, Schochetman G: DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science 239:295, 1990
21. Albert J, Fenyo D: Simple, sensitive, and specific detection of human immunodeficiency virus type 1 in clinical specimens by polymerase chain reaction with nested primers. J Clin Microbiol 28:1560, 1990
22. Zack J, Arrigo S, Weitsman S, Go A, Haislip A, Chen I: HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure. Cell 61:213, 1990
23. Saiki R, Gelfand D, Stoffel S, Scharf S, Higushi R, Horn G, Mullis K, Erlich H: Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487, 1988
24. Geissler R, Ottmann O, Kleiner K, Mentzel U, Bickelhaupt A, Hoelzer D, Ganser A: Decreased haematopoietic colony growth in long-term bone marrow cultures of HIV positive patients. Res Virol 144:69, 1993
25. +) hematopoietic progenitors in human immunodeficiency virus-1 sero-positive thrombocytopenic individuals. Blood 79:2680, 1992
26. - progenitor cells. Blood 77:1218, 1991
27. Varmus H, Padgett T, Heasley S, Simon G, Bishop J: Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA. Cell 11:307, 1977
28. Louache F, Henr IA, Bettaieb A, Oksenhendler E, Raguin G, Tulliez M, Vainchenker W: Role of human immunodeficiency virus replication in defective in vitro growth of hematopoietic progenitors. Blood 80:2991, 1992
29. + and CFU-GM progenitors are significantly decreased in SIVsmm9 infected rhesus macaques with minimal evidence of direct viral infection by polymerase chain reaction. Am J Hematol 43:274, 1993
30. Molina J, Scadden D, Sakaguchi M, Fuller B, Woon A, Groopman J: Lack of evidence for infection of or effect on growth of hematopoietic progenitor cells after in vivo or in vitro exposure to human immunodeficiency virus. Blood 76:2476, 1990
31. Kaczmarski R, Davison F, Blair E, Sutherland S, Moxham J, McManus T, Mufti G: Detection of HIV in haemopoietic progenitors. Br J Hematol 82:764, 1992
32. Eaves C, Sutherland H, Cashman J, Otsuka T, Lansdorp P, Humphries R, Eaves A, Hogge D: Regulation of primitive human hematopoietic cells in long-term marrow cultures. Semin Hematol 28:126, 1991
33. Yu M, Ojwang J, Yamada O, Hampel A, Rapapport J, Looney D, Wong-Staal F: A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 90:6340, 1993
34. Yamada O, Yu M, Yee J, Kraus G, Looney D, Wong-Staal F: Intracellular immunization of human T cells with a hairpin ribozyme against human immunodeficiency virus type 1. Gene Therapy 1:38, 1994
35. + lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme. J Virol 65:5531, 1991
36. Sarver N, Cantin E, Chang P, Zaia J, Ladne P: Ribozymes as potential anti-HIV-1 therapeutic agents. Science 247:1222, 1990
37. Holland H, Saral R, Rossi J, Donnenberg A, Burns W, Beschorner W, Farzadegan H, Jones R, Quinnan G, Vogelsang G, Vriesendorp H, Wingard J, Zaia J, Santos G: Allogeneic bone marrow transplantation, zidovudine, and human immunodeficiency virus type 1 (HIV-1) infection: Studies in a patient with non-Hodgkin lymphoma. Ann Intern Med 111:973, 1989